Non-Cochrane · aetiology · PM42763709
GLT6D1 rs1537415 G Allele and Advanced Periodontitis: A Meta-Analysis.
Karaoulas Theofanis A, Xirouchakis Christoforos, Neophytou Chariklia, et al. · Cureus · 2026 · PubMed · doi:10.7759/cureus.114871
Findings
Population People with severe periodontitis and periodontally healthy controls
2 findings
| GLT6D1 rs1537415 G allele carriers (GG or GA) | Non-carriers (AA) | Severe periodontitis (stage III/IV, grade B or C) Sensitivity analysis excluding Schaefer et al. GWAS | OR 1.37 [0.87, 2.16] GRADE not reported 2 studies |
| GLT6D1 rs1537415 G allele carriers (GG or GA) | Non-carriers (AA) | Severe periodontitis (stage III/IV, grade B or C) | OR 1.58 [1.28, 1.95] GRADE not reported 3 studies · 2185 participants |
Included primary studies 3
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Hashim 2015 Replication of the association of GLT6D1 with aggressive periodontitis in a Sudanese population. PMID:25682733 | 2015 | this review only | Severe periodontitis (stage III/IV, grade B or C) | not extracted yet |
| Rodrigues 2022 Analysis of GLT6D1 and CDKN2BAS gene polymorphisms in Brazilian patients with advanced periodontitis. PMID:35703703 | 2022 | this review only | Severe periodontitis (stage III/IV, grade B or C) | not extracted yet |
| Schaefer 2010 A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis. PMID:19897590 | 2010 | this review only | Severe periodontitis (stage III/IV, grade B or C) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Periodontitis cases (aggressive and chronic forms, validated AAP/EFP criteria) and healthy controls | 668 periodontitis cases (Stage III/IV, Grade B or C; aggressive or advanced) and 1517 healthy controls from German/Dutch, Sudanese and Brazilian populations (n=2185) |
| Intervention | GLT6D1 rs1537415 G allele carriage (GG or GA; dominant model) | rs1537415 G allele carriers (n=3 studies) |
| Comparison | Non-carriers (AA genotype) | AA genotype non-carriers (n=3 studies) |
| Outcomes | Periodontitis susceptibility (severe periodontitis, Stage III/IV, Grade B or C); OR with 95% CI | Severe periodontitis susceptibility (n=3 studies) |
| Study designs | NGS, GWAS, case-control, cohort or cross-sectional studies reporting genotype frequencies | 1 GWAS and 2 case-control studies (n=3) |
| Timing | Not specified | Not specified |