Non-Cochrane · intervention · PM42740471
Use of cells and/or biologics combined with scaffolds for soft tissue regeneration around dental implants.
Montero Eduardo, Chen Zhaozhao, Sánchez Nerea, et al. · Journal of periodontology · 2026 · PubMed · doi:10.1002/jper.70107
Findings
Population Patients with peri-implant soft tissue defects
8 findings
| Apically positioned flap plus PRF/L-PRF membrane | Apically positioned flap plus free gingival graft | Keratinized mucosa width augmentation (mm) 6 weeks to 3 months | WMD -2.0 [-3.3, -0.8] GRADE not reported 2 studies |
| PRF/L-PRF membrane around healing abutment | No scaffold or graft | Keratinized mucosa width augmentation (mm) 6 weeks to 3 months per Table 4; one included trial followed for 6 months | WMD 1.1 [0.2, 2.1] GRADE not reported 2 studies |
| PRF membranes | Baseline before treatment | Midfacial soft tissue thickness change (mm) | WME 1.4 [0.3, 2.6] GRADE not reported 3 studies |
| PRF membranes | Baseline before treatment | Occlusal soft tissue thickness change (mm) | WME 1.5 [0.1, 2.9] GRADE not reported 3 studies |
| PRF membranes or collagen matrix with rhPDGF-BB | Baseline before treatment | Soft tissue thickness change beyond mucogingival line (mm) | WME 0.46 [0.30, 0.62] GRADE not reported 2 studies |
| PRF membranes or collagen matrix with rhPDGF-BB | Baseline before treatment | Occlusal soft tissue thickness change (mm) | WME 1.33 [0.04, 2.63] GRADE not reported 4 studies |
| PRF membranes or collagen matrix with rhPDGF-BB | Baseline before treatment | Midfacial soft tissue thickness change (mm) | WME 1.5 [0.4, 2.6] GRADE not reported 4 studies |
| Cell therapy combined with soft tissue scaffold | Scaffold without cells or biologics, or no scaffold | Soft tissue augmentation | no estimate extracted No studies found 0 studies |
Included primary studies 17
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Cheruvu 2023 Evaluation of soft tissue and crestal bone changes around non-submerged implants with and without a platelet-rich fibrin membrane: A… DOI:10.17219/dmp/150408 | 2023 | 1 other review | Keratinized mucosa width augmentation (mm) | not extracted yet |
| Al-Diasty 2022 Onlay platelet-rich fibrin membrane versus free gingival graft in increasing the width of keratinized mucosa around dental implants: A… PMID:36714088 | 2022 | this review only | Keratinized mucosa width augmentation (mm) | not extracted yet |
| Cheruvu 2023 Evaluation of soft tissue and crestal bone changes around non-submerged implants with and without a platelet-rich fibrin membrane: A… PMID:37796049 | 2023 | this review only | not stated | not extracted yet |
| De Angelis 2019 Expansion of the Zone of Keratinized Tissue for Healthy Implant Abutment Interface Using De-epithelialized Amnion/Chorion Allograft DOI:10.11607/prd.3757 | 2019 | this review only | not stated | not extracted yet |
| De Angelis 2019 Expansion of the Zone of Keratinized Tissue for Healthy Implant Abutment Interface Using De-epithelialized Amnion/Chorion Allograft. PMID:30986286 | 2019 | this review only | not stated | not extracted yet |
| Patnaik 2024 Peri‐implant mucosal enhancement using leukocyte platelet rich fibrin under Sohn's poncho technique: A randomized controlled clinical trial DOI:10.1002/cap.10259 | 2023 | this review only | Keratinized mucosa width augmentation (mm) | not extracted yet |
| Patnaik 2024 Peri-implant mucosal enhancement using leukocyte platelet rich fibrin under Sohn's poncho technique: A randomized controlled clinical trial. PMID:37439152 | 2024 | this review only | not stated | not extracted yet |
| Shiezadeh 2025 Platelet-rich fibrin versus acellular dermal matrix for vertical soft tissue augmentation simultaneously with dental implantation: a… DOI:10.1186/s12903-025-06394-4 | 2025 | this review only | not stated | not extracted yet |
| Shiezadeh 2025 Platelet-rich fibrin versus acellular dermal matrix for vertical soft tissue augmentation simultaneously with dental implantation: a… PMID:40604871 | 2025 | this review only | not stated | not extracted yet |
| Simion 2012 Evaluation of a resorbable collagen matrix infused with rhPDGF-BB in peri-implant soft tissue augmentation: a preliminary report with 3.5… PMID:22408772 | 2012 | this review only | not stated | not extracted yet |
| Takashi 2023 First-in-Human Study to Investigate the Safety Assessment of Peri-Implant Soft Tissue Regeneration with Micronized-Gingival Connective… PMID:36662493 | 2023 | this review only | not stated | not extracted yet |
| Temmerman 2018 L‐<scp>PRF</scp> for increasing the width of keratinized mucosa around implants: A split‐mouth, randomized, controlled pilot clinical trial DOI:10.1111/jre.12568 | 2018 | this review only | Keratinized mucosa width augmentation (mm) | not extracted yet |
| Temmerman 2018 L-PRF for increasing the width of keratinized mucosa around implants: A split-mouth, randomized, controlled pilot clinical trial. PMID:29858875 | 2018 | this review only | not stated | not extracted yet |
| Ustaoglu 2020 Titanium-Prepared Platelet-Rich Fibrin Versus Connective Tissue Graft on Peri-Implant Soft Tissue Thickening and Keratinized Mucosa Width:… DOI:10.1016/j.joms.2020.02.019 | 2020 | this review only | not stated | not extracted yet |
| Ustaoğlu 2020 Titanium-Prepared Platelet-Rich Fibrin Versus Connective Tissue Graft on Peri-Implant Soft Tissue Thickening and Keratinized Mucosa Width:… PMID:32192925 | 2020 | this review only | not stated | not extracted yet |
| Zhan 2025 Clinical outcomes of a peri-implant keratinized mucosa augmentation procedure using concentrated growth factor: a prospective case series DOI:10.1186/s12903-025-06310-w | 2025 | this review only | not stated | not extracted yet |
| Zhan 2025 Clinical outcomes of a peri-implant keratinized mucosa augmentation procedure using concentrated growth factor: a prospective case series. PMID:40604790 | 2025 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Autogenous grafts versus substitute scaffolds for soft tissue augmentation in implant therapy: A systematic review. (2026) | 1 | 0.02 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with soft tissue defects requiring augmentation before, at or after implant placement | Implant patients needing soft tissue augmentation (171 patients, 203 sites) |
| Intervention | Cell therapy and/or biologics (ABPs, EMD, hyaluronic acid) combined with a soft tissue graft or substitute | PRF, L-PRF, T-PRF, CGF, rhPDGF-BB collagen matrix, amnion/chorion allograft, micronized gingival connective tissue with collagen matrix |
| Comparison | Soft tissue scaffold without cells or biologics, or no scaffold | FGG, CTG, ADM, no attempt to increase soft tissue; single-arm for case series |
| Outcomes | Primary: increase in STT or KM; secondary: aesthetics, volume, KM width, recession, graft shrinkage, PROMs, adverse effects | KM augmentation (n=8 studies), STT (n=5), healing index, marginal bone level, plaque, peri-implant health, PROMs, surgical time |
| Study designs | RCTs, CCTs and prospective case series with at least 6 weeks follow-up | 6 RCTs and 4 prospective case series (n=10) |
| Timing | Minimum 6 weeks follow-up | 6 weeks to 42 months |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | No | Partial Yes | no |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | Yes | Yes | yes |
| 8Included studies described in detail | Yes | Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: Partial Yes | NRSI: Yes · RCT: Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: No | NRSI: No · RCT: No | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | No | Yes | no |
| 14Heterogeneity explained | No | Yes | no |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |