Non-Cochrane · DTA · PM42713110
Integrative meta-analysis of the OSCC microbiome: from niche-specific heterogeneity to universal network and functional signatures.
Na Hee Sam, Park Jung Hwa, Kim Tae Sung · Journal of oral microbiology · 2026 · PubMed · doi:10.1080/20002297.2026.2730638
Findings
Population People with OSCC and controls in oral microbiome datasets
1 finding
| OSCC | Control | Fusobacterium: network restructuring | NetMoss score 1.0 GRADE not reported 13 studies |
Included primary studies 13
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Chen 2021 (PRJEB39064) Taxonomic and Functional Dysregulation in Salivary Microbiomes During Oral Carcinogenesis. PMID:34604102 | 2021 | 1 other review | not stated | not extracted yet |
| Granato 2021 Meta-omics analysis indicates the saliva microbiome and its proteins associated with the prognosis of oral cancer patients. PMID:33839314 | 2021 | 1 other review | not stated | not extracted yet |
| Oyeyemi 2023 Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral… PMID:38034672 | 2023 | 1 other review | not stated | not extracted yet |
| Zhang 2019 The Oral Microbiota May Have Influence on Oral Cancer. PMID:32010645 | 2019 | 1 other review | not stated | not extracted yet |
| Zhu 2023 Convergent dysbiosis of upper aerodigestive microbiota between patients with esophageal and oral cavity squamous cell carcinoma. PMID:36752573 | 2023 | 1 other review | not stated | not extracted yet |
| Chen 2021 (PRJEB37501) Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes. PMID:33089709 | 2021 | this review only | not stated | not extracted yet |
| Makinen 2023 Salivary microbiome profiles of oral cancer patients analyzed before and after treatment. PMID:37542310 | 2023 | this review only | not stated | not extracted yet |
| PRJNA1117634 (reference not reported) [Phase-difference haploscope with a varioobjective for the measurement of aniseikonia (author's transl)]. PMID:1117634 | 1975 | this review only | not stated | not extracted yet |
| Sarkar 2021 Dysbiosis of Oral Microbiota During Oral Squamous Cell Carcinoma Development. PMID:33708627 | 2021 | this review only | not stated | not extracted yet |
| Vesty 2018 Microbial and inflammatory-based salivary biomarkers of head and neck squamous cell carcinoma. PMID:30603107 | 2018 | this review only | not stated | not extracted yet |
| Wolf 2017 The salivary microbiome as an indicator of carcinogenesis in patients with oropharyngeal squamous cell carcinoma: A pilot study. PMID:28725009 | 2017 | this review only | not stated | not extracted yet |
| Zhao 2017 Variations in oral microbiota associated with oral cancer. PMID:28924229 | 2017 | this review only | not stated | not extracted yet |
| Zhou 2020 Signatures of Mucosal Microbiome in Oral Squamous Cell Carcinoma Identified Using a Random Forest Model. PMID:32753953 | 2020 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Public 16S rRNA OSCC oral microbiome datasets with paired-end raw data and BioProject accession | 13 datasets, 958 samples (Table 1) |
| Intervention | OSCC status; NetMoss2 network biomarkers; PICRUSt functional profiles | OSCC |
| Comparison | Healthy controls | Control |
| Outcomes | Alpha and beta diversity, differential taxa, NetMoss score, ROC AUC, KEGG ReporterScore | AUC saliva 0.839, mucosal 0.801, tissue 0.776, total 0.817; Fusobacterium NetMoss score 1.0 |
| Study designs | Public 16S rRNA sequencing studies | 13 public 16S datasets |
| Timing | Not specified | Not specified |