Non-Cochrane · aetiology · PM42682733

Role of third molars in mandibular fractures: a systematic umbrella review with updated meta-analysis.

Omer Shahen Hiwa, Mahmood Mohammed Khalid, Abdulghafor Mohammed Aso, et al. · Frontiers in oral health · 2026 · PubMed · doi:10.3389/froh.2026.1865229

Findings

Population Patients with mandibular fractures

94 findings

Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Gaddipati et al. 2014
RR 2.04 [1.67, 2.50]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Study quality (RR): High quality
RR 2.21 [1.16, 4.20]
GRADE not reported
9 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Study quality (RR): Low quality
RR 1.57 [0.02, 161.14]
GRADE not reported
2 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Trim and fill (OR)
OR 0.47 [0.28, 0.78]
GRADE not reported
28 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Sample size (RR): Small (N < 300)
RR 2.48 [1.38, 4.46]
GRADE not reported
10 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Fracture cause (OR): RTA
OR 0.18 [0.05, 0.68]
GRADE not reported
7 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Patil 2012
RR 2.29 [1.72, 3.05]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Subhashraj 2009
RR 2.28 [1.73, 3.02]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Leave one out: Gaddipati et al. 2014
OR 0.31 [0.21, 0.45]
GRADE not reported
19 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Leave one out: Soós et al. 2020
OR 0.27 [0.17, 0.42]
GRADE not reported
19 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Included meta-analysis: Machete 2016
RR 1.44 [1.31, 1.57]
GRADE not reported
19 studies · 9888 participants
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Mah et al. 2015
RR 2.08 [1.60, 2.71]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Time (OR): 2011–2017
OR 0.22 [0.07, 0.68]
GRADE not reported
6 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Fracture cause (OR): Violence
OR 0.38 [0.27, 0.53]
GRADE not reported
9 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Publication year 2011–2016
Unresolved: the two extractors disagree on this row.
RR 2.25 [1.15, 4.39]
GRADE not reported
Studies not reported
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Included meta-analysis: Giovacchini 2018
RR 1.90 [1.47, 2.46]
GRADE not reported
7 studies · 6750 participants
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Included meta-analysis: Xu 2017 condyle
RR .47 [.25, .86]
GRADE not reported
5 studies · 823 participants
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Ugboko et al. 2000
RR 2.24 [1.69, 2.97]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Leave one out: Mehra et al. 2019
OR 0.32 [0.23, 0.45]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular angle fracture
Leave-one-out: omitting Iida et al. 2005
RR 2.19 [1.64, 2.92]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Included meta-analysis: Hanson 2004
RR 2.8 [2.3, 3.5]
GRADE not reported
6 studies · 3002 participants
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Time (RR): 2001–2005
RR 2.54 [2.06, 3.12]
GRADE not reported
5 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Trim and fill (RR)
RR 1.45 [1.03, 2.04]
GRADE not reported
31 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Time (OR): 2001–2010
OR 0.42 [0.21, 0.83]
GRADE not reported
4 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Study quality (OR): Moderate quality
OR 0.20 [0.07, 0.58]
GRADE not reported
7 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Fracture cause (OR): Not reported
OR 0.22 [0.08, 0.62]
GRADE not reported
4 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Included meta-analysis: Armond 2017 angle
OR 3.83 [3.02, 4.85]
GRADE not reported
28 studies · 13450 participants
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Time (RR): 2006–2010
RR 1.48 [0.83, 2.63]
GRADE not reported
4 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Included meta-analysis: Xu 2017 angle
RR 2.63 [2.15, 3.21]
GRADE not reported
13 studies · 2399 participants
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular angle fracture
Leave-one-out: omitting Naghipur et al. 2014
RR 2.21 [1.65, 2.96]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Included meta-analysis: Armond 2017 condyle
OR .26 [.17, .40]
GRADE not reported
13 studies · 3814 participants
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Unresolved: the two extractors disagree on this row.
RR 0.78 [0.27, 2.24]
Very low
Downgraded: risk of bias, imprecision, inconsistency
4 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fractureOR 0.28 [0.19, 0.43]
Very low
Downgraded: risk of bias, imprecision, inconsistency
20 studies · 2495 participants
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Sample size (RR): Large (N > 300)
RR 2.01 [1.53, 2.65]
GRADE not reported
11 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Duan & Zhang 2008
RR 2.24 [1.66, 3.01]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Meisami et al. 2002
RR 2.16 [1.62, 2.88]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Study quality (OR): Low quality
OR 0.39 [0.24, 0.64]
GRADE not reported
5 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Sample size (OR): Large (N > 200)
OR 0.29 [0.16, 0.51]
GRADE not reported
12 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Rajandram et al. 2013
RR 2.12 [1.60, 2.81]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Included meta-analysis: Bezerra 2011
Unresolved: the two extractors disagree on this row.
1.94 [1.60, 2.35]
GRADE not reported
4 studies · 2533 participants
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Fracture cause (RR): Violence
RR 2.34 [1.69, 3.24]
GRADE not reported
8 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Fracture cause (RR): RTA
RR 1.94 [1.12, 3.39]
GRADE not reported
10 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Study quality (RR): Moderate quality
RR 2.36 [1.92, 2.90]
GRADE not reported
10 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fractureRR 2.18 [1.66, 2.87]
Very low
Downgraded: risk of bias, inconsistency, publication bias
21 studies · 14573 participants
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Included meta-analysis: Ruela 2017
OR 3.16 [2.20, 4.54]
GRADE not reported
16 studies · 7720 participants
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Antic et al. 2016
RR 2.21 [1.65, 2.96]
GRADE not reported
20 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular angle fracture
Leave-one-out: omitting Ma'aita & Alwrikat 2000
RR 2.18 [1.63, 2.92]
GRADE not reported
20 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular angle fracture
Leave-one-out: omitting Rajkumar et al. 2009
RR 2.28 [1.73, 3.02]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fractureOR 4.40 [3.29, 5.88]
Very low
Downgraded: risk of bias
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Time (OR): 2018–2026
OR 0.25 [0.12, 0.51]
GRADE not reported
10 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular angle fracture
Leave-one-out: omitting Luria & Campbell 2013
RR 2.19 [1.64, 2.93]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Fracture cause (RR): Not reported
RR 2.40 [1.55, 3.72]
GRADE not reported
3 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular angle fracture
Leave-one-out: omitting Tevepaugh & Dodson 1995
RR 2.16 [1.63, 2.86]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Sample size (OR): Small (N < 200)
OR 0.26 [0.12, 0.59]
GRADE not reported
8 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Thangavelu et al. 2010
RR 2.18 [1.63, 2.91]
GRADE not reported
20 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular angle fracture
Leave-one-out: omitting Lee & Dodson 2000
RR 2.2 [1.65, 2.94]
GRADE not reported
20 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular angle fracture
Leave-one-out: omitting Safdar & Meechan 1995
RR 2.18 [1.63, 2.91]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Overall, supplementary sensitivity table
Unresolved: the two extractors disagree on this row.
OR 0.28 [0.18, 0.42]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Halmos et al. 2004
RR 2.13 [1.60, 2.84]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Time (RR): <2000
RR 2.03 [1.41, 2.93]
GRADE not reported
5 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Fuselier et al. 2002
RR 2.19 [1.64, 2.94]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular condylar fracture
Study quality (OR): High quality
OR 0.28 [0.13, 0.62]
GRADE not reported
8 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Leave one out: Kasamatsu et al. 2003
RR 2.15 [1.62, 2.85]
GRADE not reported
20 studies
Mandibular third molars presentMandibular third molars absentMandibular angle fracture
Time (RR): 2011–2016
RR 2.98 [1.17, 7.58]
GRADE not reported
7 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Iida et al. 2004
OR 0.27 [0.17, 0.42]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Mah et al. 2015
OR 0.27 [0.17, 0.43]
GRADE not reported
19 studies
Pell and Gregory position C third molarNoneMandibular angle fracture
Pell and Gregory position C
OR .64 [.42, .98]
GRADE not reported
Studies not reported
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Zhu et al. 2005
OR 0.28 [0.18, 0.44]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Rozenbilds et al. 2026
OR 0.26 [0.17, 0.4]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Lee et al. 2012
OR 0.28 [0.18, 0.43]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Oh et al. 2006
OR 0.26 [0.17, 0.41]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Patil 2012
OR 0.28 [0.18, 0.44]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Nogami et al. 2018
OR 0.29 [0.19, 0.45]
GRADE not reported
19 studies
Pell and Gregory position C third molarNoneMandibular condylar fracture
Pell and Gregory position C
OR 1.57 [1.02, 2.40]
GRADE not reported
Studies not reported
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Mu et al. 2024
OR 0.27 [0.17, 0.43]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Al-Harbawee et al. 2021
OR 0.28 [0.18, 0.44]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Al-Sharani et al. 2021
OR 0.27 [0.18, 0.43]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Choi et al. 2011
OR 0.27 [0.17, 0.43]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Lee Y et al. 2019
OR 0.27 [0.17, 0.42]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Duan & Zhang 2008
OR 0.26 [0.17, 0.41]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Brucoli et al. 2020
OR 0.29 [0.19, 0.45]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Venkatachalam et al. 2022
OR 0.27 [0.17, 0.42]
GRADE not reported
19 studies
Presence of mandibular third molarsAbsence of mandibular third molarsMandibular condylar fracture
Leave-one-out: omitting Antic et al. 2016
OR 0.26 [0.17, 0.4]
GRADE not reported
19 studies
Third molar position ANoneMandibular angle fracture
Included meta-analysis: Armond 2017 angle
OR .60 [.45, .81]
GRADE not reported
Studies not reported
Third molar position ANoneMandibular condylar fracture
Included meta-analysis: Armond 2017 condyle
OR 1.32 [1.09, 1.61]
GRADE not reported
Studies not reported
Third molar position BNoneMandibular angle fracture
Included meta-analysis: Armond 2017 angle
OR 1.44 [1.06, 1.96]
GRADE not reported
Studies not reported
Third molar position BNoneMandibular condylar fracture
Included meta-analysis: Armond 2017 condyle
OR .69 [.49, .97]
GRADE not reported
Studies not reported
Third molar position INoneMandibular condylar fracture
Included meta-analysis: Armond 2017 condyle
OR 1.37 [1.05, 1.77]
GRADE not reported
Studies not reported
Third molar position INoneMandibular angle fracture
Included meta-analysis: Armond 2017 angle
OR .51 [.37, .71]
GRADE not reported
Studies not reported
Third molar position IINoneMandibular condylar fracture
Included meta-analysis: Armond 2017 condyle
OR .71 [.57, .87]
GRADE not reported
Studies not reported
Third molar position IINoneMandibular angle fracture
Included meta-analysis: Armond 2017 angle
OR 1.67 [1.36, 2.04]
GRADE not reported
Studies not reported
Third molar position IINoneMandibular angle fracture
Included meta-analysis: Giovacchini 2018
OR 2.21 [1.69, 2.87]
GRADE not reported
Studies not reported
Third molar position CNoneMandibular angle fracture
Included meta-analysis: Giovacchini 2018
OR 2.72 [1.78, 4.16]
GRADE not reported
Studies not reported
Third molar position IIINoneMandibular angle fracture
Included meta-analysis: Giovacchini 2018
OR 2.99 [2.12, 4.22]
GRADE not reported
Studies not reported

Included primary studies 42

Open in Studies
StudyYearAlso included byOutcomes it informs hereTrial data
Park et al. 2009
matched by author and year (probable)
NR1 other reviewMandibular angle fracturenot extracted yet
Al-Harbawee et al. 2021
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Al-Sharani et al. 2021
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Antic et al. 2016
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Armond 2017 (angle)
Influence of third molars in mandibular fractures. Part 1: mandibular angle—a meta-analysis
DOI:10.1016/j.ijom.2017.02.1264
2017this review onlynot statednot extracted yet
Armond 2017 (condyle)
Influence of third molars in mandibular fractures. Part 2: mandibular condyle—a meta-analysis
DOI:10.1016/j.ijom.2017.02.1265
2017this review onlynot statednot extracted yet
Bezerra 2011
Do third molars weaken the mandibular angle?
DOI:10.4317/medoral.16970
2011this review onlynot statednot extracted yet
Brucoli et al. 2020
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Choi et al. 2011
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Duan and Zhang 2008
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Fuselier et al. 2002
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Gaddipati et al. 2014
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Giovacchini 2018
Association between third molar and mandibular angle fracture: A systematic review and meta-analysis
DOI:10.1016/j.jcms.2017.12.011
2018this review onlynot statednot extracted yet
Halmos et al. 2004
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Hanson 2004
The association of third molars with mandibular angle fractures: a meta-analysis.
PMID:14709255
2004this review onlynot statednot extracted yet
Iida et al. 2004
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Iida et al. 2005
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Kasamatsu et al. 2003
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Lee and Dodson 2000
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Lee Y et al. 2019
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Luria and Campbell 2013
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Ma’aita and Alwrikat 2000
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Machete 2016
matched by author and year (probable)
NRthis review onlynot statednot extracted yet
Mehra et al. 2019
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Meisami et al. 2002
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Naghipur et al. 2014
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Nogami et al. 2018
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Patil 2012
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Rahimi-Nedjat et al. 2016
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Rajandram et al. 2013
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Rajkumar et al. 2009
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Rozenbilds et al. 2026
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Ruela 2018
Does an Association Exist Between the Presence of Lower Third Molar and Mandibular Angle Fractures?: A Meta-Analysis
DOI:10.1016/j.joms.2017.06.008
2018this review onlynot statednot extracted yet
Safdar and Meechan 1995
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Subhashraj 2009
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Tankersly and Abubaker 1995
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Tevepaugh and Dodson 1995
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Thangavelu et al. 2010
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Ugboko et al. 2000
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet
Venkatachalam et al. 2022
matched by author and year (probable)
NRthis review onlyMandibular angle fracture; Mandibular condylar fracturenot extracted yet
Xu 2017
How Is Third Molar Status Associated With the Occurrence of Mandibular Angle and Condyle Fractures?
DOI:10.1016/j.joms.2017.03.021
2017this review onlynot statednot extracted yet
Yamada et al. 1998
matched by author and year (probable)
NRthis review onlyMandibular angle fracturenot extracted yet

Overlap with other reviews

Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.

Review question

ElementPlanned (methods)Found (results)
PopulationPatients with mandibular fracturesPatients with mandibular fractures (about 40 thousand across 8 meta-analyses; about 16 thousand across 42 primary studies)
InterventionPresence of mandibular third molars (exposure)Presence of mandibular third molars (n=42 studies)
ComparisonPatients with mandibular fractures without third molarsAbsence of mandibular third molars
OutcomesRisk of mandibular angle fracture; risk of mandibular condylar fractureAngle fracture (n=41 studies; 21 RR and 20 OR estimates); condylar fracture (n=23 studies; 20 OR and 4 RR estimates)
Study designsSystematic reviews and meta-analyses reporting OR or RR with 95% CI (English, up to June 2026); updated meta-analysis of case-control or cross-sectional primary studies8 meta-analyses (6 angle, 2 condylar); 42 primary observational studies (case-control, cross-sectional, retrospective cohort)
TimingNot specifiedNot specified