Non-Cochrane · aetiology · PM42564406
Tooth Extraction Outcomes and Complications in Diabetic and Nondiabetic Individuals: A Systematic Review and Meta-Analysis to Inform Evidence-Based Guidelines.
Singh Anupam, Gadicherla Srikanth, Pentapati Kalyana C, et al. · International journal of dentistry · 2026 · PubMed · doi:10.1155/ijod/6899990
Findings
Population Adults undergoing tooth extraction
4 findings
| Diabetes mellitus (diabetic patients; exposure group) | Nondiabetic patients (control) | Infection Day 7 | RR 2.09 [0.81, 5.41] Very low Downgraded: risk of bias, imprecision 3 studies · 459 participants |
| Diabetes mellitus (diabetic patients; exposure group) | Nondiabetic patients (control) | Bony sequestra Day 7 | RR 0.63 [0.29, 1.38] Very low Downgraded: risk of bias, imprecision 2 studies · 371 participants |
| Diabetes mellitus (exposure) | Nondiabetic controls | Dry socket Maximal follow-up | Only one study reported dry socket: diabetic group 10/133 vs control group 5/133; no pooled estimate. Very low Downgraded: risk of bias, imprecision 1 study · 266 participants |
| Diabetes mellitus (diabetic patients; exposure group) | Nondiabetic patients (control) | Delayed wound healing Day 7 (2 studies) and day 21 (1 study) | RR 1.28 [0.73, 2.27] Very low Downgraded: risk of bias, imprecision 3 studies · 643 participants |
Included primary studies 5
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Fernandes 2015 Association between immunologic parameters, glycemic control, and postextraction complications in patients with type 2 diabetes. PMID:26227644 | 2015 | this review only | Delayed wound healing | not extracted yet |
| Gadicherla 2020 Comparison of Extraction Socket Healing in Non-Diabetic, Prediabetic, and Type 2 Diabetic Patients. PMID:32765113 | 2020 | this review only | Infection | not extracted yet |
| Huang 2013 The healing of dental extraction sockets in patients with Type 2 diabetes on oral hypoglycaemics: a prospective cohort. PMID:23441797 | 2013 | this review only | Delayed wound healing | not extracted yet |
| Krishnan 2021 Do preoperative glycosylated hemoglobin (HbA1C) and random blood glucose levels predict wound healing complications following exodontia in… PMID:32472252 | 2021 | this review only | Infection; Bony sequestra; Dry socket | not extracted yet |
| Power 2019 The healing of dental extraction sockets in insulin-dependent diabetic patients: a prospective controlled observational study. PMID:30525221 | 2019 | this review only | Delayed wound healing; Infection; Bony sequestra | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients undergoing tooth extraction (adults) | Adults undergoing tooth extraction (500 diabetics, 364 controls; 5 studies) |
| Intervention | Diabetic patients undergoing tooth extraction | Diabetic patients (n=500) |
| Comparison | Nondiabetic patients undergoing the same procedure | Nondiabetic controls (n=364) |
| Outcomes | Socket healing parameters with or without complications (epithelization, granulation tissue, delayed wound healing, bony sequestra, dry socket, infection) | Delayed wound healing (3 studies); infection (3 studies); bony sequestra (2 studies); dry socket (1 study); socket size (1 study) |
| Study designs | Interventional or observational studies in English comparing diabetic and nondiabetic adults | 5 observational studies (prospective cohort and comparative designs) |
| Timing | Maximal follow-up | Day 7 (delayed healing, infection, bony sequestra), day 21 (one study); follow-up 3 to 60 days across studies |