Non-Cochrane · DTA · PM42563504
Cell Blocks and the Milan System for Reporting Salivary Gland Cytopathology: A Meta-Analysis.
Närhi Aada, Kalfert David, Lagerstam Henri, et al. · Diagnostic cytopathology · 2026 · PubMed · doi:10.1002/dc.70193
Findings
14 findings
| Population | ||||
|---|---|---|---|---|
| Salivary gland fine-needle aspiration samples processed to cell blocks | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Proportion of samples in MSRSGC category SUMP (Salivary gland neoplasm of uncertain malignant potential) | Pooled proportion (%) 8.0 [3.5, 12.6] GRADE not reported 5 studies · 1132 participants |
| Salivary gland fine-needle aspiration samples processed to cell blocks | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Proportion of samples in MSRSGC category ND (Non-diagnostic) | Pooled proportion (%) 21.9 [6.0, 37.9] GRADE not reported 5 studies · 1132 participants |
| Salivary gland fine-needle aspiration samples processed to cell blocks | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Proportion of samples in MSRSGC category BN (Benign neoplasm) | Pooled proportion (%) 30.0 [15.5, 44.5] GRADE not reported 5 studies · 1132 participants |
| Salivary gland fine-needle aspiration samples processed to cell blocks | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Proportion of samples in MSRSGC category SM (Suspicious for malignancy) | Pooled proportion (%) 1.9 [1.1, 2.7] GRADE not reported 5 studies · 1132 participants |
| Salivary gland fine-needle aspiration samples processed to cell blocks | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Proportion of samples in MSRSGC category AUS (Atypia of undetermined significance) | Pooled proportion (%) 8.2 [3.3, 13.1] GRADE not reported 5 studies · 1132 participants |
| Salivary gland fine-needle aspiration samples processed to cell blocks | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Proportion of samples in MSRSGC category NN (Non-neoplastic) | Pooled proportion (%) 6.4 [3.7, 9.1] GRADE not reported 5 studies · 1132 participants |
| Salivary gland fine-needle aspiration samples processed to cell blocks | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Proportion of samples in MSRSGC category MN (Malignant) | Pooled proportion (%) 19.4 [9.8, 29.1] GRADE not reported 5 studies · 1132 participants |
| Salivary gland cell block FNA samples in each MSRSGC category with known outcome (four studies; Kumar 2023 reported no ROM) | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Risk of malignancy (ROM) in MSRSGC category ND (Non-diagnostic) | Pooled proportion (%) 25.3 [10.2, 40.5] GRADE not reported 4 studies · 133 participants |
| Salivary gland cell block FNA samples in each MSRSGC category with known outcome (four studies; Kumar 2023 reported no ROM) | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Risk of malignancy (ROM) in MSRSGC category AUS (Atypia of undetermined significance) | Pooled proportion (%) 26.3 [2.0, 50.5] GRADE not reported 4 studies · 60 participants |
| Salivary gland cell block FNA samples in each MSRSGC category with known outcome (four studies; Kumar 2023 reported no ROM) | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Risk of malignancy (ROM) in MSRSGC category MN (Malignant) | Pooled proportion (%) 97.7 [94.4, 101.1] GRADE not reported 4 studies · 72 participants |
| Salivary gland cell block FNA samples in each MSRSGC category with known outcome (four studies; Kumar 2023 reported no ROM) | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Risk of malignancy (ROM) in MSRSGC category BN (Benign neoplasm) | Pooled proportion (%) 2.0 [-0.4, 4.5] GRADE not reported 4 studies · 199 participants |
| Salivary gland cell block FNA samples in each MSRSGC category with known outcome (four studies; Kumar 2023 reported no ROM) | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Risk of malignancy (ROM) in MSRSGC category NN (Non-neoplastic) | Pooled proportion (%) 16.5 [-0.1, 34.0] GRADE not reported 4 studies · 15 participants |
| Salivary gland cell block FNA samples in each MSRSGC category with known outcome (four studies; Kumar 2023 reported no ROM) | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Risk of malignancy (ROM) in MSRSGC category SM (Suspicious for malignancy) | Pooled proportion (%) 84.8 [70.0, 99.6] GRADE not reported 4 studies · 19 participants |
| Salivary gland cell block FNA samples in each MSRSGC category with known outcome (four studies; Kumar 2023 reported no ROM) | Fine-needle aspiration with cell block preparation, classified by the Milan System (MSRSGC) | No comparator (single-arm proportion) | Risk of malignancy (ROM) in MSRSGC category SUMP (Salivary gland neoplasm of uncertain malignant potential) | Pooled proportion (%) 28.7 [18.8, 38.7] GRADE not reported 4 studies · 77 participants |
Included primary studies 5
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Behaeghe 2020 The Milan system for reporting salivary gland cytopathology: Single center experience with cell blocks. PMID:32506684 | 2020 | this review only | not stated | not extracted yet |
| Kumar 2023 Application of the Milan System for Reporting Salivary Gland Lesions and Its Cytohistological Correlation for Risk Stratification: A… PMID:38021816 | 2023 | this review only | not stated | not extracted yet |
| Morand 2022 Application of the Milan system for reporting salivary gland cytopathology using cell blocks. PMID:35750873 | 2022 | this review only | not stated | not extracted yet |
| Tabibi 2022 Ancillary studies on cell blocks from fine needle aspiration specimens of salivary gland lesions: A multi-institutional study. PMID:35092649 | 2022 | this review only | not stated | not extracted yet |
| Tommola 2021 The Contributory Role of Cell Blocks in Salivary Gland Neoplasms Fine Needle Aspirations Classified by the Milan System for Reporting… PMID:34679476 | 2021 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Salivary gland lesions diagnosed by FNA with cell block preparation | Salivary gland FNA samples processed to cell blocks (n=1132) |
| Intervention | Cell block use with Milan System (MSRSGC) categorization | Cell blocks with MSRSGC categorization (5 studies) |
| Comparison | Not specified | None |
| Outcomes | Distribution of samples per MSRSGC category; risk of malignancy per category | Pooled category proportions (5 studies, n=1132); pooled ROM per category (4 studies) |
| Study designs | Studies using cell blocks and the MSRSGC; case reports excluded | 3 retrospective and 2 prospective series, 2020 to 2023 (n=5) |
| Timing | Not specified | Not specified |