Non-Cochrane · prognostic · PM42187628
Oral Manifestations in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Scocca Veronica, Sarnelli Giovanni, Pesce Marcella, et al. · Dentistry journal · 2026 · PubMed · doi:10.3390/dj14050250
Findings
15 findings
| Population | ||||
|---|---|---|---|---|
| Patients with inflammatory bowel disease (Crohn disease and ulcerative colitis) | Inflammatory bowel disease (single-arm prevalence) | None (single-arm) | Oral ulcerations Not specified · Not specified | Prevalence (proportion) 0.20 [0.11, 0.33] GRADE not reported 13 studies · 2599 participants |
| Patients with inflammatory bowel disease (Crohn disease and ulcerative colitis) | Inflammatory bowel disease (single-arm prevalence) | None (single-arm) | Taste changes Not specified · Not specified | Prevalence (proportion) 0.16 [0.05, 0.32] GRADE not reported 6 studies · 492 participants |
| Patients with inflammatory bowel disease (Crohn disease and ulcerative colitis) | Inflammatory bowel disease (single-arm prevalence) | None (single-arm) | Dry mouth Not specified · Not specified | Prevalence (proportion) 0.32 [0.14, 0.59] GRADE not reported 8 studies · 2240 participants |
| Patients with inflammatory bowel disease (Crohn disease and ulcerative colitis) | Inflammatory bowel disease (single-arm prevalence) | None (single-arm) | Tongue alterations (coated, geographic, fissured tongue) Not specified · Not specified | Prevalence (proportion) 0.11 [0.04, 0.24] GRADE not reported 5 studies · 248 participants |
| Patients with inflammatory bowel disease (Crohn disease and ulcerative colitis) | Inflammatory bowel disease (single-arm prevalence) | None (single-arm) | Halitosis Not specified · Not specified | Prevalence (proportion) 0.22 [0.07, 0.51] GRADE not reported 9 studies · 3051 participants |
| Patients with inflammatory bowel disease (Crohn disease and ulcerative colitis) | Inflammatory bowel disease (single-arm prevalence) | None (single-arm) | Stomatitis Not specified · Not specified | Prevalence (proportion) 0.07 [0.01, 0.53] GRADE not reported 5 studies · 2713 participants |
| Patients with inflammatory bowel disease (Crohn disease and ulcerative colitis) | Inflammatory bowel disease (single-arm prevalence) | None (single-arm) | Oral aphthae Not specified · Not specified | Prevalence (proportion) 0.07 [0.02, 0.23] GRADE not reported 5 studies · 2070 participants |
| Patients with inflammatory bowel disease and healthy controls | Inflammatory bowel disease (exposure) | Healthy controls | Burning sensation Not specified · Not specified | Burning sensation: no statistically significant difference between IBD patients and healthy controls (pooled p = 0.5498); OR and CI not reported GRADE not reported Studies not reported |
| Patients with inflammatory bowel disease and healthy controls | Inflammatory bowel disease (exposure) | Healthy controls | Taste changes Not specified · Not specified | Taste changes: no statistically significant difference between IBD patients and healthy controls (pooled p = 0.618); OR and CI not reported GRADE not reported Studies not reported |
| Patients with inflammatory bowel disease and healthy controls | Inflammatory bowel disease (exposure) | Healthy controls | Lip/gingival swelling Not specified · Not specified | Lip/gingival swelling: no statistically significant difference between IBD patients and healthy controls (pooled p = 0.650); OR and CI not reported GRADE not reported Studies not reported |
| Patients with inflammatory bowel disease and healthy controls | Inflammatory bowel disease (exposure) | Healthy controls | Acidic taste Not specified · Not specified | Acidic taste: no statistically significant difference between IBD patients and healthy controls (pooled p = 0.805); OR and CI not reported GRADE not reported Studies not reported |
| Patients with inflammatory bowel disease and healthy controls | Inflammatory bowel disease (exposure) | Healthy controls | Oral ulcerations Not specified · Not specified | Oral ulcerations: no statistically significant difference between IBD patients and healthy controls (pooled p = 0.338); OR and CI not reported GRADE not reported Studies not reported |
| Patients with inflammatory bowel disease and healthy controls | Inflammatory bowel disease (exposure) | Healthy controls | Tongue alterations Not specified · Not specified | Tongue alterations: no statistically significant difference between IBD patients and healthy controls (pooled p = 0.911); OR and CI not reported GRADE not reported Studies not reported |
| Patients with inflammatory bowel disease and healthy controls | Inflammatory bowel disease (exposure) | Healthy controls | Halitosis Not specified · Not specified | Halitosis: no statistically significant difference between IBD patients and healthy controls (pooled p = 0.165); OR and CI not reported GRADE not reported Studies not reported |
| Patients with inflammatory bowel disease and healthy controls | Inflammatory bowel disease (exposure) | Healthy controls | Dry mouth Not specified · Not specified | Dry mouth: no statistically significant difference between IBD patients and healthy controls (pooled p = 0.157); OR and CI not reported GRADE not reported Studies not reported |
Included primary studies 21
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Szymanska 2014 Dental caries, prevalence and risk factors in patients with Crohn's disease. PMID:24608416 | 2014 | 1 other review | Oral ulcerations; Dry mouth; Halitosis | not extracted yet |
| Brito 2008 Prevalence of periodontitis and DMFT index in patients with Crohn's disease and ulcerative colitis. PMID:18400026 | 2008 | this review only | Oral ulcerations; Oral aphthae | not extracted yet |
| Cagir 2024 Specific Oral Manifestations in Adults with Crohn's Disease. PMID:38999519 | 2024 | this review only | not stated | not extracted yet |
| Elahi 2012 Association of oral manifestations with ulcerative colitis. PMID:24834217 | 2012 | this review only | Oral ulcerations; Dry mouth; Halitosis; Tongue alterations (coated, geographic, fissured tongue); Taste changes | not extracted yet |
| Greuter 2017 Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease: Prevalence, Presentation, and Anti-TNF Treatment. PMID:27801751 | 2017 | this review only | Oral aphthae; Stomatitis | not extracted yet |
| Grossner-Schreiber 2006 Prevalence of dental caries and periodontal disease in patients with inflammatory bowel disease: a case-control study. PMID:16820035 | 2006 | this review only | not stated | not extracted yet |
| Habashneh 2012 The association between inflammatory bowel disease and periodontitis among Jordanians: a case-control study. PMID:22050539 | 2012 | this review only | not stated | not extracted yet |
| Harty 2005 A prospective study of the oral manifestations of Crohn's disease. PMID:16234026 | 2005 | this review only | Oral ulcerations; Stomatitis | not extracted yet |
| Hu 2022 Oral Microbiome of Crohn's Disease Patients With and Without Oral Manifestations. PMID:35511486 | 2022 | this review only | Oral ulcerations | not extracted yet |
| Jose 2009 Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease. PMID:18626963 | 2009 | this review only | Oral aphthae; Stomatitis | not extracted yet |
| Katz 2003 Oral signs and symptoms in relation to disease activity and site of involvement in patients with inflammatory bowel disease. PMID:12617256 | 2003 | this review only | Oral ulcerations; Dry mouth; Halitosis; Tongue alterations (coated, geographic, fissured tongue); Taste changes | not extracted yet |
| Khouri 2004 Is orofacial granulomatosis in children a feature of Crohn's disease? PMID:16092468 | 2005 | this review only | not stated | not extracted yet |
| Khozeimeh 2020 Oral manifestations in inflammatory bowel disease: A cross-sectional study in Isfahan. PMID:34084291 | 2021 | this review only | Oral ulcerations; Dry mouth; Halitosis; Taste changes | not extracted yet |
| Koutsochristou 2015 Dental Caries and Periodontal Disease in Children and Adolescents with Inflammatory Bowel Disease: A Case-Control Study. PMID:25985243 | 2015 | this review only | Oral aphthae | not extracted yet |
| Laranjeira 2015 Oral mucosa lesions and oral symptoms in inflammatory bowel disease patients. PMID:26039827 | 2015 | this review only | Oral ulcerations; Dry mouth; Halitosis; Taste changes | not extracted yet |
| Mohan Kumar 2016 Association of oral manifestations in ulcerative colitis: A pilot study. PMID:30158772 | 2018 | this review only | Oral ulcerations; Dry mouth; Halitosis; Tongue alterations (coated, geographic, fissured tongue); Stomatitis; Taste changes | not extracted yet |
| Oviedo 2017 Frequency of Oral Manifestation in Patients with Inflammatory Bowel Disease in Chile DOI:10.4067/s0718-381x2017000300267 | 2017 | this review only | Oral ulcerations; Oral aphthae | not extracted yet |
| Rikardsson 2009 Perceived oral health in patients with Crohn's disease. PMID:19780435 | 2009 | this review only | Oral ulcerations; Dry mouth; Halitosis | not extracted yet |
| Tabarsi 2024 Association of oral manifestations with severity of the disease in ulcerative colitis patients. PMID:39448908 | 2024 | this review only | Oral ulcerations; Dry mouth; Halitosis; Tongue alterations (coated, geographic, fissured tongue); Taste changes | not extracted yet |
| Zervou 2004 matched by author and year (probable) | NR | this review only | Oral ulcerations; Tongue alterations (coated, geographic, fissured tongue) | not extracted yet |
| Zippi 2014 Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients. PMID:25516659 | 2014 | this review only | Halitosis; Stomatitis | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Oral Health Status in Patients with Inflammatory Bowel Diseases: A Systematic Review. (2021) | 1 | 0.03 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with a diagnosis of inflammatory bowel disease | Patients with IBD, 5914 patients and 1877 healthy controls (n=21) |
| Intervention | Ulcerative colitis and Crohn's disease | Crohn's disease (70%) and ulcerative colitis (30%) (n=21) |
| Comparison | IBD versus healthy controls | Healthy controls (n=12 case-control studies) |
| Outcomes | Oral signs and symptoms | Oral ulcerations (n=13), dry mouth (n=8), halitosis (n=9), tongue alterations (n=5), oral aphthae (n=5), stomatitis (n=5), taste changes (n=6); periodontal manifestations narrative (n=7) |
| Study designs | Retrospective and prospective cohort studies, case-control and cross-sectional studies, randomized clinical trials | 12 case-control studies, remainder cohort and cross-sectional (n=21) |
| Timing | None | Not specified |