Non-Cochrane · other · PM42142200
Pituitary adenoma and intracerebral aneurysms: case series, systematic review and meta-analysis.
Marino Picciola Valentino, Borghesi Michela, Trombin Vanessa, et al. · Pituitary · 2026 · PubMed · doi:10.1007/s11102-026-01690-w
Findings
25 findings
| Population | ||||
|---|---|---|---|---|
| Male patients with pituitary adenoma | None (single-group prevalence) | None (single-group prevalence) | Prevalence of intracranial aneurysms Male | Prevalence (proportion) 0.06 [0.04, 0.07] GRADE not reported 1221 participants |
| Patients with pituitary adenoma | None (single-group prevalence) | None (single-group prevalence) | Prevalence of intracranial aneurysms Overall | Prevalence (proportion) 0.04 [0.02, 0.08] GRADE not reported 10 studies · 5264 participants |
| Patients with pituitary adenoma (PA) | Coexisting intracranial aneurysm (IA) | None | Prevalence of multiple intracranial aneurysms among PA patients with an aneurysm Hospital-based PA cohorts · Overall | Prevalence 0.18 [0.11, 0.27] GRADE not reported 10 studies · 179 participants |
| Patients with pituitary adenoma | None (single-group prevalence) | None (single-group prevalence) | Prevalence of intracranial aneurysms Sex-specific estimates combined (male and female) | Prevalence (proportion) 0.07 [0.05, 0.08] GRADE not reported 2647 participants |
| Female patients with pituitary adenoma | None (single-group prevalence) | None (single-group prevalence) | Prevalence of intracranial aneurysms Female | Prevalence (proportion) 0.08 [0.06, 0.09] GRADE not reported 1426 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Non-functioning adenoma Overall | Proportion (descriptive, case-level pooling) 0.405 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Age at aneurysm diagnosis <=39 years Unresolved: the two extractors disagree on this row. | Proportion (descriptive, case-level pooling) 0.095 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Age at aneurysm diagnosis >=70 years Unresolved: the two extractors disagree on this row. | Proportion (descriptive, case-level pooling) 0.122 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Previous brain radiotherapy Overall | Proportion (descriptive, case-level pooling) 0.12 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Female sex Overall | Proportion (descriptive, case-level pooling) 0.595 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Age at aneurysm diagnosis 60-69 years Unresolved: the two extractors disagree on this row. | Proportion (descriptive, case-level pooling) 0.27 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Age at aneurysm diagnosis 40-49 years Unresolved: the two extractors disagree on this row. | Proportion (descriptive, case-level pooling) 0.176 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Macroadenoma Men | Proportion (descriptive, case-level pooling) 0.967 GRADE not reported 30 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | GH-secreting adenoma Overall | Proportion (descriptive, case-level pooling) 0.311 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Previous cranial base surgery Overall | Proportion (descriptive, case-level pooling) 0.15 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Gonadotropinoma Overall | Proportion (descriptive, case-level pooling) 0.014 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Macroadenoma Overall | Proportion (descriptive, case-level pooling) 0.919 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | ACTH-secreting adenoma Overall | Proportion (descriptive, case-level pooling) 0.027 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Age at aneurysm diagnosis 50-59 years Unresolved: the two extractors disagree on this row. | Proportion (descriptive, case-level pooling) 0.338 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Aneurysm in cavernous segment of internal carotid artery (CS-ICA) Overall | Proportion (descriptive, case-level pooling) 0.33 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Pituitary apoplexy Overall | Proportion (descriptive, case-level pooling) 0.09 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Multiple intracranial aneurysms Overall | Proportion (descriptive, case-level pooling) 0.135 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Aneurysm of anterior communicating artery (ACoA) Overall Unresolved: the two extractors disagree on this row. | Proportion (descriptive, case-level pooling) 0.17 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | PRL-secreting adenoma Overall | Proportion (descriptive, case-level pooling) 0.243 GRADE not reported 74 participants |
| Patients with coexisting pituitary adenoma and intracranial aneurysm (Group 1, individual patient data from case reports and series) | None (single-group prevalence) | None (single-group prevalence) | Macroadenoma Women | Proportion (descriptive, case-level pooling) 0.886 GRADE not reported 44 participants |
Included primary studies 59
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Acqui M. et al., 1987 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Adachi K. et al., 1993 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Agarwal H. et al., 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Akutsu N. et al., 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Almeida Silva JM et al., 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bulsara K. et al., 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Choi HS.et al., 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Chuang C.C et al., 2006 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Cifuentes-Lobelo H. et al., 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Curto L. et al., 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Fedder S. L. et al., 1990 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Fookeerah P. & McLean M., 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Fujiwara S. et al., 1991 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Giammusso V., 1960 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hermier M. et al., 1994 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hidenori E. et al., 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Holdaway M. et al., 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hori T. et al., 1982 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Inoue H. et al., 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Jakubowski J. 1978 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Jintao Hu, 2019 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Keenan J. P. et al., 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khachatryan T. et al., 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khalsa S. S. et al., 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lippman H. H. et al., 1971 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Manara R. et al., 2011 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Mangiardi J. R. et al., 1983 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Min Chul O. et al., 2012 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Mondragon-Soto M. G. et al., 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nadjem H. et al., 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nakahara M et al., 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nene A. et al., 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nishijima Y. et al., 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pant B. et al., 1997 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Pedrozo C. A. et al., 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Rennert R. C et al., 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Revuelta R. et al., 2002 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sade B. et al., 2004 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Salpietro F. M. et al., 1997 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Satoru O. et al., 2012 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Satyarthee G. D. & Raheja A., 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Schenk V. W. & Solleveld H., 1968 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Seda L. Jr et al., 2008 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Shahlaie K. et al., 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Taiki S. et al., 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Taniguchi T. et al., 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Villalobos-Diaz R. et al., 2024 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Wakai S. et al., 1979 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wang CS et al., 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wang T et al., 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Xia X. et al., 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Xin M. et al., 2023 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Yamada S. et al., 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yamashita S. et al., 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yang MY. et al., 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yoshida M. et al., 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yoshikazu O. et al., 2022 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
| Zatelli M. C. et al., 2004 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zheng H. et al., 2024 matched by author and year (probable) | NR | this review only | Prevalence of intracranial aneurysms | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with pituitary adenoma and coexisting intracranial aneurysm, any age | Group 1: 74 patients with both PA and IA; Group 2: 5264 patients with PA from 10 studies |
| Intervention | Coexisting intracranial aneurysm (condition of interest) | Intracranial aneurysm (cavernous ICA most frequent site, 33%) |
| Comparison | Not specified | Not specified |
| Outcomes | Clinical features of patients with both conditions; prevalence of IAs in PA patients | Pooled IA prevalence among PA patients 4% (n=5264); male 6% (n=1221), female 8% (n=1426); multiple IAs 18% (n=179) |
| Study designs | Any study design reporting cases or cohorts (case reports, case series, retrospective and cross-sectional studies); abstracts, reviews and editorials excluded | Case reports, case series and prevalence studies (n=71) |
| Timing | Not specified | Not specified |