Non-Cochrane · intervention · PM42088729
Cytocompatibility of Three Calcium Silicate-Based Biomaterials: A Systematic Review and Meta-Analysis.
Shabani Panbeh Choleh Sahar, Heidari Mahmoud, Kazeminejad Ezatolah, et al. · Iranian endodontic journal · 2026 · PubMed · doi:10.22037/iej.v21i1.48350
Findings
109 findings
| Population | ||||
|---|---|---|---|---|
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD 0.43 [-1.72, 2.57] GRADE not reported 5 studies · 44 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -0.18 [-1.26, 0.90] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD -0.99 [-1.84, -0.13] GRADE not reported 2 studies · 20 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD 0.31 [-1.23, 1.85] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Margunato 2015 omitted | SMD 1.07 [-1.18, 3.31] GRADE not reported 5 studies · 48 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Saberi 2016 omitted | SMD -0.25 [-1.41, 0.90] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture | SMD 0.74 [-1.13, 2.61] GRADE not reported 6 studies · 54 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -0.82 [-1.46, -0.18] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -0.12 [-1.33, 1.08] GRADE not reported 6 studies · 46 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Sultana 2018 omitted | SMD -0.45 [-1.63, 0.72] GRADE not reported 6 studies · 52 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture | SMD -0.39 [-1.38, 0.60] GRADE not reported 7 studies · 60 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Margunato 2015 omitted | SMD -0.50 [-1.64, 0.64] GRADE not reported 6 studies · 54 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD -0.20 [-1.29, 0.90] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Saberi 2016 omitted | SMD -3.19 [-7.05, 0.67] GRADE not reported 2 studies · 20 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Sultana 2018 omitted | SMD 0.27 [-1.72, 2.25] GRADE not reported 5 studies · 46 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 5 days exposure · In vitro cell culture | SMD -0.13 [-1.01, 0.75] GRADE not reported 2 studies · 14 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Agrafioti 2016 omitted | SMD 0.25 [-1.71, 2.21] GRADE not reported 5 studies · 44 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Margunato 2015 omitted | SMD 0.39 [-1.16, 1.94] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Dahake 2020 omitted | SMD 0.91 [-1.54, 3.35] GRADE not reported 5 studies · 44 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD -0.30 [-1.44, 0.85] GRADE not reported 6 studies · 54 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Sultana 2018 omitted | SMD 0.26 [-1.28, 1.81] GRADE not reported 6 studies · 48 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -2.85 [-7.42, 1.72] GRADE not reported 2 studies · 20 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Saberi 2016 omitted | SMD 1.51 [-0.13, 3.16] GRADE not reported 5 studies · 44 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture | SMD -2.11 [-4.14, -0.08] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Youssef 2019 omitted | SMD 0.20 [-0.79, 1.20] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture | SMD 0.30 [-0.96, 1.56] GRADE not reported 7 studies · 56 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD 0.68 [-0.60, 1.96] GRADE not reported 6 studies · 46 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD 0.46 [-1.11, 2.03] GRADE not reported 6 studies · 46 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -0.62 [-1.31, 0.08] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD 1.25 [0.32, 2.18] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD 0.52 [-0.18, 1.22] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD -0.13 [-1.23, 0.96] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture | SMD -0.21 [-1.02, 0.59] GRADE not reported 4 studies · 36 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD 1.06 [-0.19, 2.30] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD -0.01 [-1.01, 1.00] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD 0.85 [-0.42, 2.11] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture | SMD -2.20 [-6.98, 2.59] GRADE not reported 2 studies · 20 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -0.08 [-1.19, 1.02] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture | SMD 0.90 [-0.00, 1.81] GRADE not reported 4 studies · 36 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD 0.63 [-0.80, 2.06] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD 0.17 [-0.64, 0.98] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD 0.18 [-0.51, 0.86] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture | SMD 0.25 [-0.34, 0.84] GRADE not reported 4 studies · 36 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture | SMD 0.55 [-0.44, 1.53] GRADE not reported 4 studies · 36 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture | SMD -0.99 [-3.36, 1.38] GRADE not reported 2 studies · 20 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD 0.91 [0.04, 1.79] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD 0.06 [-0.62, 0.74] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD 0.41 [-0.28, 1.10] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD 0.36 [-0.30, 1.02] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | MTA 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD 0.49 [-0.93, 1.91] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD -0.58 [-3.77, 2.61] GRADE not reported 7 studies · 56 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Sultana 2018 omitted | SMD -1.46 [-5.36, 2.45] GRADE not reported 7 studies · 58 participants |
| Human cell lines (e.g., dental pulp stem cells, gingival fibroblasts) in vitro | Biodentine extract, undiluted (non-diluted) | Untreated control group | Cell viability (normalized to control, % viability) 48 hours · In vitro cell culture · Leave-one-out sensitivity analysis omitting Tomas-Catala 2018 | SMD -0.91 [-3.61, 1.78] GRADE not reported 3 studies |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture | SMD -1.71 [-4.37, 0.96] GRADE not reported 4 studies · 40 participants |
| Human cell lines (e.g., dental pulp stem cells, gingival fibroblasts) in vitro | Biodentine extract, undiluted (non-diluted) | Untreated control group | Cell viability (normalized to control, % viability) 48 hours · In vitro cell culture · Leave-one-out sensitivity analysis omitting Omidi 2019 | SMD -2.65 [-6.84, 1.53] GRADE not reported 3 studies |
| Human cell lines (e.g., dental pulp stem cells, gingival fibroblasts) in vitro | Biodentine extract, undiluted (non-diluted) | Untreated control group | Cell viability (normalized to control, % viability) 48 hours · In vitro cell culture · Leave-one-out sensitivity analysis omitting Collado-Gonzalez 2017 | SMD -0.63 [-3.07, 1.81] GRADE not reported 3 studies |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD -1.71 [-6.15, 2.73] GRADE not reported 7 studies · 60 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Margunato 2015 omitted | SMD -0.58 [-2.01, 0.85] GRADE not reported 6 studies · 54 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture | SMD -1.75 [-4.99, 1.49] GRADE not reported 8 studies · 66 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -0.91 [-3.61, 1.78] GRADE not reported 3 studies · 30 participants |
| Human cell lines (e.g., dental pulp stem cells, gingival fibroblasts) in vitro | Biodentine extract, undiluted (non-diluted) | Untreated control group | Cell viability (normalized to control, % viability) 48 hours · In vitro cell culture · Leave-one-out sensitivity analysis omitting Saberi 2016 | SMD -2.76 [-6.70, 1.19] GRADE not reported 3 studies |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Margunato 2015 omitted | SMD -3.12 [-6.40, 0.16] GRADE not reported 7 studies · 60 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD 0.35 [-1.69, 2.39] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -2.18 [-6.21, 1.85] GRADE not reported 7 studies · 56 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -1.07 [-2.35, 0.21] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD -0.63 [-3.07, 1.81] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture | SMD 0.15 [-1.58, 1.89] GRADE not reported 6 studies · 54 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Saberi 2016 omitted | SMD 0.39 [-1.55, 2.34] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Saberi 2016 omitted | SMD -2.76 [-6.70, 1.19] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Saberi 2016 omitted | SMD 0.72 [-1.27, 2.72] GRADE not reported 5 studies · 44 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -0.54 [-3.71, 2.62] GRADE not reported 7 studies · 56 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Youssef 2019 omitted | SMD -2.87 [-5.99, 0.24] GRADE not reported 7 studies · 60 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Omidi 2019 omitted | SMD -1.07 [-4.51, 2.37] GRADE not reported 7 studies · 56 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Agrafioti 2016 omitted | SMD 0.64 [-1.59, 2.86] GRADE not reported 5 studies · 44 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD 0.24 [-1.81, 2.29] GRADE not reported 6 studies · 54 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture | SMD -0.09 [-1.77, 1.59] GRADE not reported 7 studies · 60 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 5 days exposure · In vitro cell culture | SMD 0.73 [-0.52, 1.97] GRADE not reported 2 studies · 14 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -0.50 [-2.14, 1.14] GRADE not reported 5 studies · 44 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Omidi 2019 omitted | SMD -2.65 [-6.84, 1.53] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Sultana 2018 omitted | SMD 0.09 [-2.00, 2.17] GRADE not reported 6 studies · 52 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Dahake 2020 omitted | SMD 0.66 [-1.51, 2.84] GRADE not reported 5 studies · 44 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Margunato 2015 omitted | SMD 0.49 [-1.73, 2.71] GRADE not reported 5 studies · 48 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 7 days exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Sultana 2018 omitted | SMD -0.60 [-1.95, 0.74] GRADE not reported 5 studies · 46 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD 0.36 [-1.65, 2.38] GRADE not reported 6 studies · 50 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD -0.01 [-0.73, 0.72] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -0.17 [-1.00, 0.67] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -0.38 [-1.07, 0.31] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture | SMD -5.66 [-14.50, 3.18] GRADE not reported 2 studies · 20 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -2.21 [-6.16, 1.75] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture | SMD -0.11 [-0.70, 0.48] GRADE not reported 4 studies · 36 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD -1.81 [-5.54, 1.91] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD 0.08 [-0.61, 0.76] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD -6.28 [-15.89, 3.33] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture | SMD -4.06 [-8.27, 0.14] GRADE not reported 4 studies · 36 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:2 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -6.92 [-14.93, 1.08] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD -1.05 [-3.32, 1.22] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -0.44 [-1.58, 0.70] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -0.83 [-1.79, 0.13] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture | SMD -3.90 [-6.85, -0.94] GRADE not reported 2 studies · 20 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Zhou 2013 omitted | SMD -1.49 [-2.81, -0.17] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD -0.45 [-2.33, 1.44] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture | SMD -0.55 [-1.39, 0.29] GRADE not reported 4 studies · 36 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Collado-Gonzalez 2017 omitted | SMD -0.22 [-0.90, 0.47] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Assadian 2022 omitted | SMD -0.75 [-1.81, 0.31] GRADE not reported 3 studies · 30 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture | SMD -0.83 [-2.43, 0.76] GRADE not reported 4 studies · 36 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | Biodentine 1:4 diluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture · Leave-one-out sensitivity analysis: Tomas-Catala 2018 omitted | SMD -0.36 [-2.11, 1.39] GRADE not reported 3 studies · 26 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | CEM cement undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 24 hours exposure · In vitro cell culture | SMD -0.39 [-1.89, 1.11] GRADE not reported 2 studies · 16 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | CEM cement undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 48 hours exposure · In vitro cell culture | SMD 0.31 [-0.49, 1.11] GRADE not reported 2 studies · 20 participants |
| Human cell lines (dental pulp stem cells, gingival and periodontal fibroblasts, bone marrow stem cells, SHED) | CEM cement undiluted extract | Untreated control | Cell viability (percent of control; MTT and other viability assays) 72 hours exposure · In vitro cell culture | SMD -2.80 [-8.62, 3.01] GRADE not reported 2 studies · 16 participants |
Included primary studies 61
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Saberi 2015 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Zhou 2013 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Agrafioti 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Agrafioti 2016 Interaction of dental pulp stem cells with Biodentine and MTA after exposure to different environments. PMID:27812618 | 2016 | this review only | not stated | not extracted yet |
| Akbulut 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Akbulut 2018 Effects of four novel root-end filling materials on the viability of periodontal ligament fibroblasts. PMID:30135845 | 2018 | this review only | not stated | not extracted yet |
| Assadian 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Assadian 2022 Comparative evaluation of the effects of three hydraulic calcium silicate cements on odontoblastic differentiation of human dental pulp… PMID:36350874 | 2022 | this review only | not stated | not extracted yet |
| Attik 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Attik 2014 In vitro biocompatibility of a dentine substitute cement on human MG63 osteoblasts cells: Biodentine™ versus MTA(®). PMID:24517569 | 2014 | this review only | not stated | not extracted yet |
| Birant 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Birant 2021 Cytotoxicity of NeoMTA Plus, ProRoot MTA and Biodentine on human dental pulp stem cells. PMID:34141112 | 2021 | this review only | not stated | not extracted yet |
| Bortoluzzi 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bortoluzzi 2015 Cytotoxicity and osteogenic potential of silicate calcium cements as potential protective materials for pulpal revascularization. PMID:26494267 | 2015 | this review only | not stated | not extracted yet |
| Bossu 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bossu 2021 Biocompatibility and Antibiofilm Properties of Calcium Silicate-Based Cements: An In Vitro Evaluation and Report of Two Clinical Cases. PMID:34073519 | 2021 | this review only | not stated | not extracted yet |
| Collado-Gonzalez 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Collado-Gonzalez 2017 Cytotoxicity and bioactivity of various pulpotomy materials on stem cells from human exfoliated primary teeth. PMID:28169432 | 2017 | this review only | not stated | not extracted yet |
| Costa 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Costa 2016 Osteogenic and Angiogenic Response to Calcium Silicate-based Endodontic Sealers. PMID:26577874 | 2016 | this review only | not stated | not extracted yet |
| Dahake 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Dahake 2020 Response of stem cells from human exfoliated deciduous teeth (SHED) to three bioinductive materials - An in vitro experimental study. PMID:31920278 | 2020 | this review only | not stated | not extracted yet |
| Gomes-Cornelio 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gomes-Cornelio 2017 Bioactivity of MTA Plus, Biodentine and an experimental calcium silicate-based cement on human osteoblast-like cells. PMID:26610093 | 2017 | this review only | not stated | not extracted yet |
| Hengameh 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hengameh 2014 Effects of two bioactive materials on survival and osteoblastic differentiation of human mesenchymal stem cells. PMID:25125848 | 2014 | this review only | not stated | not extracted yet |
| Jovanovic 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khedmat 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khedmat 2013 Sealing ability of three commercial mineral trioxide aggregates and an experimental root-end filling material. PMID:24454452 | 2006 | this review only | not stated | not extracted yet |
| Kucukkaya 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kucukkaya 2016 In Vitro Cytotoxicity of Calcium Silicate-Based Endodontic Cement as Root-End Filling Materials. PMID:26904364 | 2016 | this review only | not stated | not extracted yet |
| Margunato 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Margunato 2015 In Vitro Evaluation of ProRoot MTA, Biodentine, and MM-MTA on Human Alveolar Bone Marrow Stem Cells in Terms of Biocompatibility and… PMID:26410417 | 2015 | this review only | not stated | not extracted yet |
| Omidi 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Omidi 2019 The effect of different pulp-capping materials on proliferation, migration and cytokine secretion of human dental pulp stem cells. PMID:32695293 | 2020 | this review only | not stated | not extracted yet |
| Pedano 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pedano 2018 Freshly-mixed and setting calcium-silicate cements stimulate human dental pulp cells. PMID:29525357 | 2018 | this review only | not stated | not extracted yet |
| Pedrosa 2022a matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pedrosa 2022a Exposure to lipopolysaccharide and calcium silicate-based materials affects the behavior of dental pulp cells. PMID:36287503 | 2022 | this review only | not stated | not extracted yet |
| Pedrosa 2022b matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pedrosa 2022b Calcium silicate-based cements affect the cell viability and the release of TGF-β1 from apical papilla cells. PMID:35019013 | 2021 | this review only | not stated | not extracted yet |
| Pelepenko 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pelepenko 2021 Physicochemical, antimicrobial, and biological properties of White-MTAFlow. PMID:32864726 | 2021 | this review only | not stated | not extracted yet |
| Pinheiro 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pinheiro 2018 Cell Viability and Tissue Reaction of NeoMTA Plus: An In Vitro and In Vivo Study. PMID:29866406 | 2018 | this review only | not stated | not extracted yet |
| Saberi 2015 Cytotoxicity of Various Endodontic Materials on Stem Cells of Human Apical Papilla. PMID:26843872 | 2016 | this review only | not stated | not extracted yet |
| Saberi 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Saberi 2016 (Table 5 ref 45; Table 3 row 4) Cytotoxic effects of mineral trioxide aggregate, calcium enrichedmixture cement, Biodentine and octacalcium pohosphate onhuman gingival… PMID:27429722 | 2016 | this review only | not stated | not extracted yet |
| Samyuktha 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Samyuktha 2014 Cytotoxicity evaluation of root repair materials in human-cultured periodontal ligament fibroblasts. PMID:25298650 | 2014 | this review only | not stated | not extracted yet |
| Sismanoglu 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sismanoglu 2022 Effects of calcium silicate-based cements on odonto/osteogenic differentiation potential in mesenchymal stem cells. PMID:35229930 | 2023 | this review only | not stated | not extracted yet |
| Sultana 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sultana 2018 Evaluation of Biocompatibility and Osteogenic Potential of Tricalcium Silicate-based Cements Using Human Bone Marrow-derived Mesenchymal… PMID:29306530 | 2018 | this review only | not stated | not extracted yet |
| Tomas-Catala 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tomas-Catala 2018 Biocompatibility of New Pulp-capping Materials NeoMTA Plus, MTA Repair HP, and Biodentine on Human Dental Pulp Stem Cells. PMID:29079052 | 2018 | this review only | not stated | not extracted yet |
| Weekate 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Weekate 2021 Alterations of mitochondrial dynamics, inflammation and mineralization potential of lipopolysaccharide-induced human dental pulp cells… PMID:33503268 | 2021 | this review only | not stated | not extracted yet |
| Youssef 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Youssef 2019 Effects of mineral trioxide aggregate, calcium hydroxide, biodentine and Emdogain on osteogenesis, Odontogenesis, angiogenesis and cell… PMID:31266498 | 2019 | this review only | not stated | not extracted yet |
| Zhou 2013 In vitro cytotoxicity evaluation of a novel root repair material. PMID:23522540 | 2013 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human cell lines (in vitro); animal cell lines excluded | Human dental pulp stem cells (6 studies), human gingival fibroblasts (2), SHED (2), hBMSCs (2) among 11 meta-analysis studies; 32 studies overall |
| Intervention | MTA, Biodentine and CEM cement extracts | MTA, Biodentine, CEM cement (undiluted, 1:2 and 1:4 extracts) |
| Comparison | At least two different materials compared with each other; control group | Untreated control group |
| Outcomes | Cytotoxicity measured by cell viability assays (e.g., MTT) | Cell viability (normalized percentage), pooled as SMD |
| Study designs | In vitro studies in English published up to February 16, 2023 | 32 in vitro studies in the review (n=32); 11 in meta-analysis (n=11) |
| Timing | Not specified | 24, 48 and 72 hours; 5 and 7 days |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | No | No | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Partial Yes · NRSI: N/A | NRSI: Yes · RCT: N/A | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | NRSI: Yes · RCT: N/A | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | No | No | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |