Non-Cochrane · DTA · PM42078330
Diagnostic efficacy of VELscope in oral potentially malignant disorders: a systematic review and meta-analysis.
Li Yan, Li Zhibang, Wang Wenru, et al. · Frontiers in oral health · 2026 · PubMed · doi:10.3389/froh.2026.1811909
Findings
Population Patients with oral potentially malignant disorders (OPMD)
19 findings
| VELscope autofluorescence imaging | Histopathology (reference standard) | Sensitivity Clinical (oral examination) · Comparative study: yes | Sensitivity 0.72 [0.59, 0.85] GRADE not reported 6 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Sensitivity Clinical (oral examination) | Sensitivity 0.84 [0.78, 0.89] GRADE not reported 24 studies · 2363 participants |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Diagnostic odds ratio Clinical (oral examination) | DOR 4.52 [2.50, 8.16] GRADE not reported 24 studies · 2363 participants |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Diagnostic score Clinical (oral examination) | Diagnostic score 1.51 [0.92, 2.10] GRADE not reported 24 studies · 2363 participants |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Specificity Clinical (oral examination) · Comparative study: yes | Specificity 0.46 [0.20, 0.72] GRADE not reported 6 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Area under the SROC curve Clinical (oral examination) | AUC 0.78 [0.74, 0.81] GRADE not reported 24 studies · 2363 participants |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Specificity Clinical (oral examination) · High risk of bias: yes | Specificity 0.52 [0.29, 0.75] GRADE not reported 8 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Sensitivity Clinical (oral examination) · High risk of bias: no | Sensitivity 0.86 [0.81, 0.92] GRADE not reported 16 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Specificity Clinical (oral examination) · Comparative study: no | Specificity 0.45 [0.30, 0.60] GRADE not reported 18 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Negative likelihood ratio Clinical (oral examination) | Negative likelihood ratio 0.34 [0.23, 0.51] GRADE not reported 24 studies · 2363 participants |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Specificity Clinical (oral examination) · SCIE indexed: no | Specificity 0.45 [0.23, 0.67] GRADE not reported 9 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Sensitivity Clinical (oral examination) · High risk of bias: yes | Sensitivity 0.80 [0.69, 0.91] GRADE not reported 8 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Positive likelihood ratio Clinical (oral examination) | Positive likelihood ratio 1.55 [1.22, 1.96] GRADE not reported 24 studies · 2363 participants |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Specificity Clinical (oral examination) · SCIE indexed: yes | Specificity 0.46 [0.30, 0.62] GRADE not reported 15 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Sensitivity Clinical (oral examination) · SCIE indexed: yes | Sensitivity 0.82 [0.75, 0.89] GRADE not reported 15 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Specificity Clinical (oral examination) | Specificity 0.45 [0.33, 0.59] GRADE not reported 24 studies · 2363 participants |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Sensitivity Clinical (oral examination) · SCIE indexed: no | Sensitivity 0.88 [0.81, 0.95] GRADE not reported 9 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Specificity Clinical (oral examination) · High risk of bias: no | Specificity 0.42 [0.27, 0.58] GRADE not reported 16 studies |
| VELscope autofluorescence imaging | Histopathology (reference standard) | Sensitivity Clinical (oral examination) · Comparative study: no | Sensitivity 0.87 [0.83, 0.92] GRADE not reported 18 studies |
Included primary studies 24
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Mehrotra 2010 A cross-sectional study evaluating chemiluminescence and autofluorescence in the detection of clinically innocuous precancerous and… PMID:20123872 | 2010 | 1 other review | not stated | not extracted yet |
| Adil 2017 Comparative study on the efficacy of tissue autofluorescence (visually enhanced lesion scope) and toluidine blue as a screening method in… DOI:10.4103/jmedsci.jmedsci_53_16 | 2017 | this review only | not stated | not extracted yet |
| Amirchaghmaghi 2018 The diagnostic value of the native fluorescence visualization device for early detection of premalignant/malignant lesions of the oral… PMID:29079347 | 2018 | this review only | not stated | not extracted yet |
| Awan 2011 Evaluation of an autofluorescence based imaging system (VELscope™) in the detection of oral potentially malignant disorders and benign… PMID:21396880 | 2011 | this review only | not stated | not extracted yet |
| Canjau 2018 Fluorescence influence on screening decisions for oral malignant lesions. PMID:29940629 | 2018 | this review only | not stated | not extracted yet |
| Chiang 2019 Comparative evaluation of autofluorescence imaging and histopathological investigation for oral potentially malignant disorders in Taiwan. PMID:30302607 | 2019 | this review only | not stated | not extracted yet |
| Farah 2012 Efficacy of tissue autofluorescence imaging (VELScope) in the visualization of oral mucosal lesions. PMID:21818819 | 2012 | this review only | not stated | not extracted yet |
| Ganga 2017 Evaluation of the diagnostic efficacy and spectrum of autofluorescence of benign, dysplastic and malignant lesions of the oral cavity… PMID:29224826 | 2017 | this review only | not stated | not extracted yet |
| Gao 2025 DOI:10.3969/i.issn.1001-3733.2025.05.015 | NR | this review only | not stated | not extracted yet |
| Hang 2019 DOI:10.7655/nydxbns20191236 | NR | this review only | not stated | not extracted yet |
| Koch 2011 Effectiveness of autofluorescence to identify suspicious oral lesions--a prospective, blinded clinical trial. PMID:20714910 | 2011 | this review only | not stated | not extracted yet |
| Leuci 2020 May VelScope Be Deemed an Opportunistic Oral Cancer Screening by General Dentists? A Pilot Study. PMID:32516953 | 2020 | this review only | not stated | not extracted yet |
| Paderni 2011 Direct visualization of oral-cavity tissue fluorescence as novel aid for early oral cancer diagnosis and potentially malignant disorders… PMID:21781457 | 2011 | this review only | not stated | not extracted yet |
| Petruzzi 2014 Evaluation of autofluorescence and toluidine blue in the differentiation of oral dysplastic and neoplastic lesions from non dysplastic and… PMID:24996662 | 2014 | this review only | not stated | not extracted yet |
| Scheer 2011 Autofluorescence imaging of potentially malignant mucosa lesions. PMID:21429774 | 2011 | this review only | not stated | not extracted yet |
| Sharma 2022 To Evaluate the Efficacy of Tissue Autofluorescence (Velscope) in the Visualization of Oral Premalignant and Malignant Lesions among… PMID:35966910 | 2022 | this review only | not stated | not extracted yet |
| Shi 2019 Potential role of autofluorescence imaging in determining biopsy of oral potentially malignant disorders: A large prospective diagnostic… PMID:31416690 | 2019 | this review only | not stated | not extracted yet |
| Tatapudi 2025 Comparing the efficacy of VELscope with vital stains in the diagnosis of (common) oral potentially malignant disorders an observational… PMID:40930494 | 2026 | this review only | not stated | not extracted yet |
| Vibhute 2021 Velscope guided oral cancer screening: A ray of hope in early oral cancer diagnosis. PMID:35281151 | 2021 | this review only | not stated | not extracted yet |
| Wang 2022 Diagnostic value of objective VELscope fluorescence methods in distinguishing oral cancer from oral potentially malignant disorders (OPMDs). PMID:35836514 | 2022 | this review only | not stated | not extracted yet |
| Wu 2020 DOI:10.27680/d.cnki.gzyyc.2020.000081 | NR | this review only | not stated | not extracted yet |
| Yamamoto 2017 Detection accuracy for epithelial dysplasia using an objective autofluorescence visualization method based on the luminance ratio. PMID:29125138 | 2017 | this review only | not stated | not extracted yet |
| Yeladandi 2024 A Cross-Sectional Study on Oral Potentially Malignant Disorders: Diagnostic Challenges in Early Detection of Dysplasia and the Role of… PMID:39416560 | 2024 | this review only | not stated | not extracted yet |
| Zhu 2025 DOI:10.3969/i.issn.1001-3733.2025.03.015 | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Available Evidence on the Diagnostic Accuracy of Chemiluminescence for Detecting Dysplasia or Malignant Transformation in Oral Potentially… (2026) | 1 | 0.03 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients with OPMD | OPMD patients (n=2363) in 24 studies |
| Intervention | VELscope for diagnosis of OPMD with pathological diagnosis as gold standard | VELscope (24 studies) |
| Comparison | Studies evaluating VELscope alone or comparing it with other methods (e.g., chemical staining) | Histopathology reference standard; 6 studies also compared toluidine blue (3), iodine staining (1), another autofluorescence device (1), oral examination (1) |
| Outcomes | TP, FP, TN, FN; sensitivity, specificity, likelihood ratios, SROC | Sensitivity, specificity, PLR, NLR, diagnostic score, DOR, AUC |
| Study designs | Prospective or cross-sectional studies | Prospective and cross-sectional studies (24) |
| Timing | Not specified | Not specified |