Non-Cochrane · aetiology · PM41972126
Familial and genetic overlap between Sjögren's disease and other autoimmune diseases.
Ono-Minagi Hitomi, Ohnishi Takuma, Atyeo Natalie, et al. · Frontiers in immunology · 2026 · PubMed · doi:10.3389/fimmu.2026.1740360
Findings
12 findings
| Population | ||||
|---|---|---|---|---|
| SjD probands and their first-degree relatives | Proband SjD (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Common-effects model | RR 9.62 [8.47, 10.92] GRADE not reported 3 studies |
| SjD probands and their first-degree relatives | Proband SjD (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Random-effects model | RR 10.54 [7.85, 14.16] GRADE not reported 3 studies |
| SjD probands and their first-degree relatives | Proband SjD (exposure) | Probands or controls without the disease of interest | Familial risk of any other autoimmune disease in first-degree relatives Random-effects model | RR 4.25 [1.85, 9.79] GRADE not reported 4 studies |
| SjD probands and their first-degree relatives | Proband SjD (exposure) | Probands or controls without the disease of interest | Familial risk of any other autoimmune disease in first-degree relatives Common-effects model | RR 7.38 [6.38, 8.54] GRADE not reported 4 studies |
| RA probands and their first-degree relatives | Proband RA (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Common-effects model | RR 1.92 [1.71, 2.14] GRADE not reported 2 studies |
| RA probands and their first-degree relatives | Proband RA (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Random-effects model | RR 2.21 [1.28, 3.82] GRADE not reported 2 studies |
| SLE probands and their first-degree relatives | Proband SLE (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Random-effects model | RR 4.49 [2.87, 7.03] GRADE not reported 3 studies |
| SLE probands and their first-degree relatives | Proband SLE (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Common-effects model | RR 4.94 [4.26, 5.72] GRADE not reported 3 studies |
| SSc probands and their first-degree relatives | Proband SSc (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Random-effects model | RR 2.65 [1.66, 4.21] GRADE not reported 2 studies |
| SSc probands and their first-degree relatives | Proband SSc (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Common-effects model | RR 2.65 [1.66, 4.21] GRADE not reported 2 studies |
| IIM probands and their first-degree relatives | Proband IIM (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Random-effects model | RR 0.47 [0.17, 1.28] GRADE not reported 3 studies |
| IIM probands and their first-degree relatives | Proband IIM (exposure) | Probands or controls without the disease of interest | Familial risk of SjD in first-degree relatives Common-effects model | RR 0.47 [0.17, 1.28] GRADE not reported 3 studies |
Included primary studies 18
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Alexandra 2018 (Balbir-Gurman 2019) Autoimmune Diseases in Systemic Sclerosis Patients and Their Relatives: Data from a Single Center. PMID:30685902 | 2019 | this review only | not stated | not extracted yet |
| Anaya 2006 Autoimmune disease aggregation in families with primary Sjögren's syndrome. PMID:17086607 | 2006 | this review only | Familial risk of any other autoimmune disease in first-degree relatives | not extracted yet |
| Ben-Eli 2019 Shared Medical and Environmental Risk Factors in Dry Eye Syndrome, Sjogren's Syndrome, and B-Cell Non-Hodgkin Lymphoma: A Case-Control… PMID:30805374 | 2019 | this review only | Familial risk of any other autoimmune disease in first-degree relatives | not extracted yet |
| Bengtsson 2002 Risk factors for developing systemic lupus erythematosus: a case-control study in southern Sweden. PMID:12011382 | 2002 | this review only | Familial risk of SjD in first-degree relatives | not extracted yet |
| Eaton 2007 Epidemiology of autoimmune diseases in Denmark. PMID:17582741 | 2007 | this review only | Familial risk of SjD in first-degree relatives | not extracted yet |
| Ginn 1998 Familial autoimmunity in pedigrees of idiopathic inflammatory myopathy patients suggests common genetic risk factors for many autoimmune… PMID:9506566 | 1998 | this review only | Familial risk of SjD in first-degree relatives | not extracted yet |
| Hemminki 2009 Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions. PMID:19248111 | 2009 | this review only | not stated | not extracted yet |
| Hemminki 2010 The epidemiology of Graves' disease: evidence of a genetic and an environmental contribution. PMID:20056533 | 2010 | this review only | not stated | not extracted yet |
| Kuo 2015a Familial Risk of Sjögren's Syndrome and Co-aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study. PMID:25940005 | 2015 | this review only | Familial risk of SjD in first-degree relatives | not extracted yet |
| Kuo 2015b Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families. PMID:26193127 | 2015 | this review only | not stated | not extracted yet |
| Kuo 2016 Familial risk of systemic sclerosis and co-aggregation of autoimmune diseases in affected families. PMID:27729087 | 2016 | this review only | Familial risk of SjD in first-degree relatives | not extracted yet |
| Kuo 2018 Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families. PMID:30349392 | 2018 | this review only | not stated | not extracted yet |
| Mescheriakova 2019 No excess of autoimmune diseases in multiple sclerosis families from the Netherlands. PMID:29315461 | 2018 | this review only | not stated | not extracted yet |
| Nielsen 2008 Autoimmune diseases in patients with multiple sclerosis and their first-degree relatives: a nationwide cohort study in Denmark. PMID:18573841 | 2008 | this review only | not stated | not extracted yet |
| Priori 2003 Familial autoimmunity as a risk factor for systemic lupus erythematosus and vice versa: a case-control study. PMID:14596421 | 2003 | this review only | not stated | not extracted yet |
| Priori 2007 Risk factors for Sjögren's syndrome: a case-control study. PMID:17631733 | 2007 | this review only | Familial risk of any other autoimmune disease in first-degree relatives | not extracted yet |
| Thomsen 2020a Familial associations for rheumatoid autoimmune diseases. PMID:33241174 | 2020 | this review only | Familial risk of SjD in first-degree relatives; Familial risk of any other autoimmune disease in first-degree relatives | not extracted yet |
| Thomsen 2020b Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden. PMID:32743538 | 2020 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Probands or first-degree relatives with Sjogren disease and nine autoimmune diseases (SjD, SLE, SSc, RA, IIM, MS, T1D, GD, HT) | SjD probands and probands with RA, SLE, SSc, IIM, MS, T1D, GD, HT (pooled analyses: SjD, RA, SLE, SSc, IIM) |
| Intervention | Family history of autoimmune disease in first-degree relatives (proband disease status) | Concordant and discordant autoimmune disease in first-degree relatives (n=18 studies; 15 distinct SjD associations) |
| Comparison | Probands or relatives without the autoimmune disease (non-familial/sporadic controls) | Non-affected probands/controls |
| Outcomes | Relative risk of SjD or other autoimmune disease in first-degree relatives | Pooled RR: SjD->SjD 10.54; SjD->other AD 4.25; RA->SjD 2.21; SLE->SjD 4.49; SSc->SjD 2.65; IIM->SjD 0.47 |
| Study designs | Cohort and case-control studies, 1 January 1980 to 16 February 2025 | Cohort and case-control studies published 1998-2020 (USA, Sweden, Italy, Colombia, Denmark, Taiwan, Israel, Netherlands) |
| Timing | Not specified | Not specified |