Non-Cochrane · aetiology · PM41948871
Signaling Through SCFA Receptors Gpr43 and Gpr109a Drives Pro-Inflammatory M1 Macrophage Polarization in Periodontitis.
Liu Kun, Wang Ruolin, Kong Lingxue, et al. · Mediators of inflammation · 2026 · PubMed · doi:10.1155/mi/3542645
Findings
Population Patients with periodontitis
19 findings
| Periodontitis (case status) | Healthy controls | Acetate concentration leave-one-out: omitting Koike 2020 · GCF or saliva | SMD -0.26 [-0.74, 0.23] GRADE not reported 2 studies |
| Periodontitis (case status) | Healthy controls | Isovalerate concentration overall · GCF or saliva | SMD 0.45 [-0.08, 0.97] GRADE not reported 2 studies · 77 participants |
| Periodontitis (case status) | Healthy controls | Propionate concentration overall · GCF or saliva | SMD 0.06 [-1.56, 1.67] GRADE not reported 3 studies · 89 participants |
| Periodontitis (case status) | Healthy controls | Butyrate concentration leave-one-out: omitting Lu 2014 · GCF or saliva | SMD -2.76 [-11.08, 5.57] GRADE not reported 2 studies |
| Periodontitis (case status) | Healthy controls | Butyrate concentration leave-one-out: omitting Li 2012 · GCF or saliva | SMD -3.24 [-10.56, 4.09] GRADE not reported 2 studies |
| Periodontitis (case status) | Healthy controls | Propionate concentration GCF or saliva · Sample source: gingival crevicular fluid | SMD 0.83 [0.36, 1.3] GRADE not reported 2 studies · 77 participants |
| Periodontitis (case status) | Healthy controls | Propionate concentration GCF or saliva · Platform: HPCE | SMD 0.83 [0.36, 1.3] GRADE not reported 2 studies · 77 participants |
| Periodontitis (case status) | Healthy controls | All SCFAs combined (propionate, butyrate, acetate, isovalerate) overall random-effects across SCFAs · GCF or saliva | SMD -0.46 [-0.8, -0.11] GRADE not reported 4 studies |
| Periodontitis (case status) | Healthy controls | Butyrate concentration overall · GCF or saliva | SMD -1.58 [-6.53, 3.36] GRADE not reported 3 studies · 89 participants |
| Periodontitis (case status) | Healthy controls | Butyrate concentration leave-one-out: omitting Koike 2020 · GCF or saliva | SMD 0.77 [-0.22, 1.77] GRADE not reported 2 studies |
| Periodontitis (case status) | Healthy controls | Propionate concentration leave-one-out: omitting Li 2012 · GCF or saliva | SMD -0.41 [-3.03, 2.21] GRADE not reported 2 studies |
| Periodontitis (case status) | Healthy controls | Acetate concentration overall · GCF or saliva | SMD -0.6 [-1.41, 0.21] GRADE not reported 3 studies · 82 participants |
| Periodontitis (case status) | Healthy controls | Acetate concentration leave-one-out: omitting Hatanaka 2022 · GCF or saliva | SMD -0.81 [-2.48, 0.87] GRADE not reported 2 studies |
| Periodontitis (case status) | Healthy controls | Propionate concentration leave-one-out: omitting Lu 2014 · GCF or saliva | SMD -0.43 [-3.01, 2.15] GRADE not reported 2 studies |
| Periodontitis (case status) | Healthy controls | Propionate concentration leave-one-out: omitting Koike 2020 · GCF or saliva | SMD 0.83 [0.36, 1.3] GRADE not reported 2 studies |
| Periodontitis (case status) | Healthy controls | Acetate concentration GCF or saliva · Sample source: saliva | SMD -1.02 [-2.21, 0.17] GRADE not reported 2 studies · 42 participants |
| Periodontitis (case status) | Healthy controls | Butyrate concentration GCF or saliva · Sample source: gingival crevicular fluid | SMD 0.77 [-0.22, 1.77] GRADE not reported 2 studies · 77 participants |
| Periodontitis (case status) | Healthy controls | Butyrate concentration GCF or saliva · Platform: HPCE | SMD 0.77 [-0.22, 1.77] GRADE not reported 2 studies · 77 participants |
| Periodontitis (case status) | Healthy controls | Acetate concentration leave-one-out: omitting Lu 2014 · GCF or saliva | SMD -1.02 [-2.21, 0.17] GRADE not reported 2 studies |
Included primary studies 4
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Hatanaka 2022 Enzymatic measurement of short-chain fatty acids and application in periodontal disease diagnosis. PMID:35839206 | 2022 | this review only | not stated | not extracted yet |
| Koike 2020 Butyric Acid in Saliva of Chronic Periodontitis Patients Induces Transcription of the EBV Lytic Switch Activator BZLF1: A Pilot Study. PMID:32111757 | 2020 | this review only | not stated | not extracted yet |
| Li 2012 (cited as Qiqiang) Longitudinal study of volatile fatty acids in the gingival crevicular fluid of patients with periodontitis before and after nonsurgical… PMID:22594616 | 2012 | this review only | not stated | not extracted yet |
| Lu 2014 Effect of non-surgical periodontal treatment on short chain fatty acid levels in gingival crevicular fluid of patients with generalized… PMID:25340203 | 2014 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human periodontitis patients and healthy controls | Periodontitis patients and healthy controls (n=4 studies; sample sizes 12 to 40) |
| Intervention | Periodontitis (case group); microbial metabolite (SCFA) levels measured by GC-MS or LC-MS metabolomics | Periodontitis (GCF or saliva SCFA measured by HPCE, GC-MS or HPLC) |
| Comparison | Healthy controls | Healthy controls |
| Outcomes | Concentrations of short-chain fatty acids (acetate, propionate, butyrate, isovalerate); correlations with inflammatory markers | Propionate (n=3), butyrate (n=3), acetate (n=3), isovalerate (n=2) concentrations; SMD |
| Study designs | Case-control studies | Four studies labeled RCT in Table 1 (described as case-control in Methods) |
| Timing | Not specified | Not specified |