Non-Cochrane · aetiology · PM41874205

Hepatitis B Virus Infection and Risk Factors Among Pregnant Women in Healthcare Facilities in West Africa: A Systematic Review and Meta-Analysis.

Hassane Fatimata, Lagare Adamou, Yacouba Abdourahamane, et al. · BioMed research international · 2026 · PubMed · doi:10.1155/bmri/3975525

Findings

Population Pregnant women attending healthcare facilities in West Africa

35 findings

Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Gestational age: Third trimester
Pooled prevalence (%) 8.2 [5.6, 11.2]
GRADE not reported
21 studies · 3900 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Gambia
Pooled prevalence (%) 6.5 [2.6, 11.9]
GRADE not reported
2 studies · 10105 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Gravidity: Primigravidae
Pooled prevalence (%) 8.6 [5.7, 11.9]
GRADE not reported
9 studies · 4034 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Gravidity: Multigravidae
Pooled prevalence (%) 11.3 [7.1, 16.4]
GRADE not reported
9 studies · 3748 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · HBV diagnostic method: Chemiluminescence immunoassay
Pooled prevalence (%) 6.5 [5.4, 7.8]
GRADE not reported
1 study · 1622 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · HBV diagnostic method: ELISA
Pooled prevalence (%) 9.4 [7.8, 11.2]
GRADE not reported
77 studies · 57878 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · World Bank income group: Lower middle-income countries
Pooled prevalence (%) 7.7 [6.9, 8.5]
GRADE not reported
104 studies · 2902780 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Mauritania
Pooled prevalence (%) 10.7 [8.9, 12.7]
GRADE not reported
1 study · 1020 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · HBV diagnostic method: Lateral flow chromatography immunoassay
Pooled prevalence (%) 5.7 [4.7, 6.9]
GRADE not reported
34 studies · 56642 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Overall
Pooled prevalence (%) 8.0 [7.3, 8.6]
GRADE not reported
129 studies · 2928715 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Senegal
Pooled prevalence (%) 9.8 [6.6, 13.7]
GRADE not reported
2 studies · 4077 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Gestational age: Second trimester
Pooled prevalence (%) 6.9 [4.8, 9.3]
GRADE not reported
20 studies · 4851 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Parity: Nulliparous
Pooled prevalence (%) 3.8 [1.9, 6.4]
GRADE not reported
7 studies · 1208 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Burkina Faso
Pooled prevalence (%) 11.2 [8.4, 14.4]
GRADE not reported
14 studies · 8721 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
post-2010 · Healthcare facilities (antenatal clinics and hospitals) in West Africa · Vaccination period: Postvaccination (post-2010)
Pooled prevalence (%) 7.3 [6.6, 8.1]
GRADE not reported
49 studies · 2852537 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Sierra Leone
Pooled prevalence (%) 9.2 [5.9, 13]
GRADE not reported
4 studies · 923 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Parity: Primiparous
Pooled prevalence (%) 8.1 [4.3, 12.8]
GRADE not reported
20 studies · 6599 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Niger
Pooled prevalence (%) 16.2 [13, 19.5]
GRADE not reported
1 study · 495 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Parity: Multiparous
Pooled prevalence (%) 11 [6.4, 16.6]
GRADE not reported
21 studies · 9350 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Benin
Pooled prevalence (%) 11 [7.4, 15.2]
GRADE not reported
3 studies · 1484 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Ghana
Pooled prevalence (%) 8.5 [6.9, 10.3]
GRADE not reported
21 studies · 15262 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Nigeria
Pooled prevalence (%) 6.6 [5.8, 7.5]
GRADE not reported
73 studies · 2874600 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Gestational age: First trimester
Pooled prevalence (%) 5.3 [2.3, 9.3]
GRADE not reported
17 studies · 1294 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · World Bank income group: Low-income countries
Pooled prevalence (%) 10.7 [8.7, 12.9]
GRADE not reported
25 studies · 26265 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Mali
Pooled prevalence (%) 11.6 [8.2, 15.6]
GRADE not reported
5 studies · 6358 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
2000-2010 · Healthcare facilities (antenatal clinics and hospitals) in West Africa · Vaccination period: Transition period (2000-2010)
Pooled prevalence (%) 7.8 [6, 9.8]
GRADE not reported
36 studies · 50266 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · HBV diagnostic method: Radioimmunoassay
Pooled prevalence (%) 11.4 [5.2, 19.7]
GRADE not reported
2 studies · 2271 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · HBV diagnostic method: Latex agglutination test
Pooled prevalence (%) 6.4 [2.5, 11.9]
GRADE not reported
5 studies · 4858 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
pre-2000 · Healthcare facilities (antenatal clinics and hospitals) in West Africa · Vaccination period: Prevaccination (pre-2000)
Pooled prevalence (%) 9.9 [6.4, 14]
GRADE not reported
6 studies · 4473 participants
Not applicable (prevalence)Not applicableHBsAg seroprevalence (HBV infection)
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Country: Ivory Coast
Pooled prevalence (%) 10 [4.8, 16.7]
GRADE not reported
3 studies · 5670 participants
Not applicable (prevalence)Not applicableHBeAg prevalence among HBsAg-positive pregnant women
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Overall
Pooled prevalence (%) 15 [10.5, 19.9]
GRADE not reported
33 studies · 1603 participants
Not applicable (prevalence)Not applicableHBV DNA prevalence in pregnant women
Healthcare facilities (antenatal clinics and hospitals) in West Africa · Overall
Pooled prevalence (%) 7.6 [5.9, 9.4]
GRADE not reported
16 studies · 32808 participants
History of blood transfusionNo history of blood transfusionHBV infection
Healthcare facilities (antenatal clinics and hospitals) in West Africa
OR 1.76 [1.27, 2.45]
GRADE not reported
35 studies · 13742 participants
History of body tattooNo history of body tattooHBV infection
Healthcare facilities (antenatal clinics and hospitals) in West Africa
OR 2.28 [1.08, 4.79]
GRADE not reported
10 studies · 5601 participants
History of dental careNo history of dental careHBV infection
Healthcare facilities (antenatal clinics and hospitals) in West Africa
OR 1.35 [0.78, 2.36]
GRADE not reported
11 studies · 3215 participants

Included primary studies 127

Open in Studies
StudyYearAlso included byOutcomes it informs hereTrial data
Abulude et al., 2017
The experience of schizophrenia.
PMID:201754
19771 other reviewnot statednot extracted yet
Abdullahi et al., 2011
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Aboubakar et al., 2020
Hypothalamo-pituitary-adrenal function in pituitary adenoma and craniopharyngioma. Part I: Insulin test, lysine-vasopressin test, and…
PMID:202036
1977this review onlynot statednot extracted yet
Abuku et al., 2023
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Acquaye et al., 1994
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Adegbesan-Omilabu et al., 2015
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Adeogun et al., 2020
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Adesina et al., 2010
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Adeyemi et al., 2014
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Adjei et al., 2018
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Adu-Sarkodie et al., 1996
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Agbozo et al., 2018
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Aigere et al., 2013
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Ajayi et al., 2013
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Ajileye et al., 2020
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Akani et al., 2005
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Alassan et al., 2019
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Aluor et al., 2016
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Anabire et al., 2023
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Anaedobe et al., 2015
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Andernach et al., 2014
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Antuamwine et al., 2022
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Apea-Kudi et al., 2006
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Atilola et al., 2018
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Ayoola et al., 1982
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Baba et al., 1999
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Bejide et al., 2024
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Bigot et al., 1992
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Bittaye et al., 2019
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Buseri et al., 2010
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Candotti et al., 2007
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Collenberg et al., 2006
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Damale et al., 2005
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De Paschale et al., 2014
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Dortey et al., 2020
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Doumbia et al., 2022
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Eduku et al., 2024
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Eke et al., 2011
Prevalence of HIV antibodies in the antenatal clinic attenders in Ciskei.
PMID:2011812
1991this review onlynot statednot extracted yet
Ephraim et al., 2015
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Erhabor et al., 2020
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Evelyn et al., 2009
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Ezechi et al., 2014
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Falaye et al., 2014
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Faleye et al., 2014
Are British psychiatrists racist?
PMID:2015443
1991this review onlynot statednot extracted yet
Fofana et al., 2023
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Fowotade et al., 2021
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Frempong et al., 2019
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Ghazzawi et al., 2022
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Guingane et al., 2022
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Harry et al., 1994
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Helegbe et al., 2018
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Ifeorah et al., 2017
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Ikeme et al., 2006
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Iklaki et al., 2015
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Ilboudo et al., 2002
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Ilboudo et al., 2007
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Ilboudo et al., 2010
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Jatau et al., 2009
Generation of periodic amplitude and phase filters.
PMID:20094279
1970this review onlynot statednot extracted yet
Kolawole et al., 2012
Outcome over seven years of healthy adults with and without subjective cognitive impairment.
PMID:20129317
2010this review onlynot statednot extracted yet
Kouakou et al., 2020
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Kuugbe et al., 2023
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Kwadzokpui et al., 2020
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Lohoues et al., 1998
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Luuse et al., 2016
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Maclean et al., 2012
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Magagi et al., 2021
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Maiga et al., 1992
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Mamadou et al., 2012
Improved lung preservation with cold air storage.
PMID:2012414
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Mansour et al., 2012
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Marinier et al., 1985
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Mbaawuaga et al., 2008
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Mustapha et al., 2020
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Nacro et al., 2000
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Ndako et al., 2012
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Ndams et al., 2009
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Ndow et al., 2023
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Ndububa et al., 2022
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Njoku et al., 2015
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Njoku et al., 2020
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Nkrumah et al., 2011
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Nongo et al., 2016
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Nwuzo et al., 2020
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Odjiegbe et al., 2015
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Okafor et al., 1979
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Okeke et al., 2012
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Olakunde et al., 2021
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Olaleye et al., 2015
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Olaolu et al., 2023
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Olofinsae et al., 2014
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Olokoba et al., 2011
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Oluremi et al., 2020
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Omalu et al., 2012
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Omatola et al., 2019
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Omatola et al., 2021
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Omote et al., 2020
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Onakewhor et al., 2001
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Onwere et al., 2012
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Opaleye et al., 2016
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Ouermi et al., 2009
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Ouoba et al., 2022
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Ouoba et al., 2023
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Pennap et al., 2011
Requirements for screening and confirmatory methods for the detection and quantification of marine biotoxins in end-product and official…
PMID:20112011
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Pennap et al., 2015
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Rabiu et al., 2010
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Roingeard et al., 1993
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Rouet et al., 2004
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Sangare et al., 2009
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Sanou et al., 2018
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Simpore et al., 2006
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Talla et al., 2021
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Torlesse et al., 1997
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Ugbebor et al., 2011
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Ugwu et al., 2022
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Ukwu et al., 2015
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Umoke et al., 2021
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Usanga et al., 2011
Genetic and environmental factors causing variation in drug response.
PMID:2011142
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Utoo et al., 2013
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Volker et al., 2017
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Wurie et al., 2005
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Yakasai et al., 2012
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Yelemkoure et al., 2018
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Yendewa et al., 2021
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Yoon et al., 2012
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Overlap with other reviews

Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.

Review question

ElementPlanned (methods)Found (results)
PopulationPregnant women in West African countriesPregnant women attending healthcare facilities in 11 West African countries (n=2,928,715 for HBsAg)
InterventionExposure/risk factors for HBV infection (e.g., blood transfusion, body tattoo, dental care); prevalence of HBsAg, HBeAg, HBV DNAHBsAg (129 studies), HBeAg (33 studies), HBV DNA (16 studies); risk factors blood transfusion (35 studies), body tattoo (10), dental care (11)
ComparisonNot specifiedNot specified
OutcomesPrevalence of HBV infection (HBsAg, HBeAg, HBV DNA) and risk factors associated with HBV infectionPooled HBsAg prevalence 8.0% (95% CI 7.3 to 8.6); HBeAg 15% (10.5 to 19.9); HBV DNA 7.6% (5.9 to 9.4); ORs for blood transfusion, body tattoo and dental care
Study designsObservational studies (case-control, cross-sectional, cohort)138 studies: 129 cross-sectional, 6 cohort, 3 case-control; all in healthcare facilities
TimingNo restriction on publication date; English or French; searches to April 3, 2024Study periods 1977 to 2023