Non-Cochrane · aetiology · PM41870030
Association Between Solid Organ Transplantation and Oral Candidiasis: A Systematic Review and Meta-Analysis.
Shah Neha, Sinha Sangeeta, Sonthalia Abhay, et al. · Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry · 2026 · PubMed · doi:10.1111/scd.70157
Findings
16 findings
| Population | ||||
|---|---|---|---|---|
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · All organs pooled | OR 3.52 [1.92, 6.46] 112 [44, 213] per 1000 Moderate 9 studies · 3354 participants |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting King et al. (1994) | log OR 1.40 [0.58, 2.22] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting Olczak-Kowalczyk et al. (2010) | log OR 1.16 [0.57, 1.74] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting Gulec et al. (2003) | log OR 1.55 [0.71, 2.38] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting Gulec et al. (2010) | log OR 1.47 [0.60, 2.33] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting Imko-Walczuk et al. (2014) | log OR 1.54 [0.76, 2.31] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting Lopez-Pintor et al. (2010, 2013) | log OR 1.55 [0.74, 2.36] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting Al-Mohaya et al. (2009) | log OR 1.10 [0.57, 1.62] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting Antoniewicz et al. (2009) | log OR 0.85 [0.51, 1.19] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Solid organ transplantation (any organ) | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Leave-one-out sensitivity analysis omitting Dongari-Bagtzoglou et al. (2009) | log OR 1.16 [0.59, 1.73] GRADE not reported 8 studies |
| Patients who received solid organ transplants | Kidney transplantation | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Kidney transplant recipients | OR 3.53 [1.92, 6.49] 112 [44, 214] per 1000 Moderate 9 studies · 3016 participants |
| Patients who received solid organ transplants | Liver transplantation | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Liver transplant recipients | OR 20.12 [3.83, 105.74] 478 [124, 803] per 1000 Moderate Downgraded: imprecision 2 studies · 597 participants |
| Patients who received solid organ transplants | Heart transplantation | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Heart transplant recipients | OR 89.91 [10.66, 758.60] 842 [-446, 933] per 1000 Moderate Downgraded: imprecision 2 studies · 602 participants |
| Patients who received solid organ transplants | Heart transplantation | Patients without solid organ transplant (controls) | Oral candidiasis (clinical plus mycological confirmation) Case-control comparisons of transplant recipients with controls · Heart transplant recipients | OR 152.01 [17.71, 1304.96] Moderate Downgraded: imprecision 2 studies · 602 participants |
| Pancreas transplant recipients | Pancreas transplantation | Controls without solid organ transplant | Oral candidiasis Transplant recipients and controls (clinical settings) · Pancreas transplant recipients (planned subgroup by organ transplanted) | no estimate extracted No studies found 0 studies |
| Small bowel transplant recipients | Small bowel transplantation | Controls without solid organ transplant | Oral candidiasis Transplant recipients and controls (clinical settings) · Small bowel transplant recipients (planned subgroup by organ transplanted) | no estimate extracted No studies found 0 studies |
Included primary studies 13
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Al-Mohaya 2009 Oral lesions in Saudi renal transplant patients. PMID:19112215 | 2009 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| Antoniewicz 2009 Mucosal Candida infection and colonisation as well as associated risk factors in solid organ transplant recipients. PMID:19340468 | 2009 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| Dongari-Bagtzoglou 2009 Oral Candida infection and colonization in solid organ transplant recipients. PMID:19416456 | 2009 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| Ghadimi 2023 Oral candidiasis in patients with kidney transplantation in Iran: prevalence and antifungal susceptibility pattern. PMID:37665236 | 2023 | this review only | not stated | not extracted yet |
| Gülec 2003 Superficial fungal infections in 102 renal transplant recipients: a case-control study. PMID:12894063 | 2003 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| Gülec 2010 Lip and oral mucosal lesions in 100 renal transplant recipients. PMID:19926164 | 2010 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| Imko-Walczuk 2014 Superficial fungal infections in renal transplant recipients. PMID:25380906 | 2014 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| King 1994 Prevalence and risk factors associated with leukoplakia, hairy leukoplakia, erythematous candidiasis, and gingival hyperplasia in renal… PMID:7898908 | 1994 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| López-Pintor 2010 Comparison of oral lesion prevalence in renal transplant patients under immunosuppressive therapy and healthy controls. PMID:19656317 | 2010 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| López-Pintor 2013 Oral candidiasis in patients with renal transplants. PMID:23385511 | 2013 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| Olczak-Kowalczyk 2010 Oral candidiasis in immunosuppressed children and young adults after liver or kidney transplantation. PMID:20557701 | 2010 | this review only | Oral candidiasis (clinical plus mycological confirmation) | not extracted yet |
| Rezvani 2014 Oral manifestations of allograft recipients before and after renal transplantation. PMID:24625992 | 2014 | this review only | not stated | not extracted yet |
| Zarei 2020 Molecular characterization of fungi causing colonization and infection in organ transplant recipients: a one-year prospective study DOI:10.18502/cmm.6.1.2505 | 2020 | this review only | not stated | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients who received solid organ transplants (heart, lung, liver, kidney, small bowel, pancreas) | Solid organ transplant recipients, mainly kidney (12 studies; n=1618), liver (3 studies; n=152), heart (3 studies; n=135), lung (1 study; n=92); total 1997 recipients |
| Intervention | Solid organ transplantation (exposure) | Solid organ transplantation |
| Comparison | Patients without solid organ transplant (case-control studies); patients before transplantation (longitudinal studies) | Healthy controls without transplant (9 case-control studies); pre-transplant status (3 cohort studies, not pooled) |
| Outcomes | Risk of oral candidiasis (clinical diagnosis confirmed by mycological examination, biopsy or response to antifungal treatment) | Oral candidiasis (odds ratio) |
| Study designs | Case-control and cohort studies | 9 case-control studies pooled; 3 prospective cohort studies not pooled (12 studies, 13 articles) |
| Timing | Not specified | Follow-up in cohort studies 4 to 6 months; mean post-transplant period in case-control studies about 4.5 to 6.8 years |