Non-Cochrane · intervention · PM41793737
Failures and complications associated with resorbable and non-resorbable membranes in guided bone regeneration: A systematic review and meta-analysis.
Cousiño D-S, Egido-Moreno S, Navarro B-G, et al. · Medicina oral, patologia oral y cirugia bucal · 2026 · PubMed · doi:10.4317/medoral.27721
Findings
Population Patients undergoing guided bone regeneration
6 findings
| e-PTFE (non-resorbable) membrane | Collagen (resorbable) membrane | Bone formation (mm) | MD -0.09 [-0.41, 0.22] GRADE not reported 5 studies · 160 participants |
| e-PTFE (non-resorbable) membrane | Collagen (resorbable) membrane | Complications | RR 1.01 [0.69, 1.48] GRADE not reported 9 studies · 253 participants |
| e-PTFE (non-resorbable) membrane | Collagen (resorbable) membrane | Success rate | RR 1.0 [0.95, 1.06] GRADE not reported 9 studies · 265 participants |
| e-PTFE (non-resorbable) membrane | Polyglactin 910 (resorbable) membrane | Complications | RR 1.0 [0.02, 45.5] GRADE not reported 2 studies · 54 participants |
| e-PTFE (non-resorbable) membrane | Polyglactin 910 (resorbable) membrane | Success rate | RR 1.03 [0.84, 1.26] GRADE not reported 2 studies · 55 participants |
| e-PTFE (non-resorbable) membrane | Polylactide/polyglycolide (resorbable) membrane | Success rate | RR 0.98 [0.87, 1.1] GRADE not reported 2 studies · 66 participants |
Included primary studies 25
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Luongo 2022 New insights into cholesterol dynamics. PMID:202222 | 1978 | 1 other review | not stated | not extracted yet |
| Antoun 2001 A prospective randomized study comparing two techniques of bone augmentation: onlay graft alone or associated with a membrane. PMID:11737108 | 2001 | this review only | not stated | not extracted yet |
| Carpio 2000 Guided bone regeneration around endosseous implants with anorganic bovine bone mineral. A randomized controlled trial comparing… PMID:11128923 | 2000 | this review only | Bone formation (mm); Success rate; Complications | not extracted yet |
| Chen 2004 A prospective clinical study of bone augmentation techniques at immediate implants. PMID:15777327 | 2005 | this review only | Success rate | not extracted yet |
| Couri 2002 Medical grade calcium sulfate hemihydrate versus expanded polytetrafluoroethylene in the treatment of mandibular class II furcations. PMID:12479641 | 2002 | this review only | not stated | not extracted yet |
| Cucchi 2017 Evaluation of complication rates and vertical bone gain after guided bone regeneration with non-resorbable membranes versus titanium… PMID:28745035 | 2017 | this review only | not stated | not extracted yet |
| Cucchi 2019 (3) Histological and histomorphometric analysis of bone tissue after guided bone regeneration with non-resorbable membranes vs resorbable… PMID:31286649 | 2019 | this review only | not stated | not extracted yet |
| Cucchi 2019 (10) A Proposal of Pseudo-periosteum Classification After GBR by Means of Titanium-Reinforced d-PTFE Membranes or Titanium Meshes Plus… PMID:31226196 | 2019 | this review only | not stated | not extracted yet |
| Dahlin 2010 Long-term follow-up on soft and hard tissue levels following guided bone regeneration treatment in combination with a xenogeneic filling… PMID:19438941 | 2010 | this review only | Success rate; Complications | not extracted yet |
| Eickholz 2006 Stability of clinical and radiographic results after guided tissue regeneration in infrabony defects. PMID:17199537 | 2007 | this review only | not stated | not extracted yet |
| Eickholz 2007 Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers. III. Class II furcations after 10… PMID:16579708 | 2006 | this review only | not stated | not extracted yet |
| Friedmann 2003 Histological assessment of augmented jaw bone utilizing a new collagen barrier membrane compared to a standard barrier membrane to protect… PMID:12519332 | 2002 | this review only | Success rate; Complications | not extracted yet |
| Jung 2013 Long-term outcome of implants placed with guided bone regeneration (GBR) using resorbable and non-resorbable membranes after 12-14 years. PMID:22697628 | 2013 | this review only | Success rate; Complications | not extracted yet |
| Khoury 2001 Surgical therapy of peri-implant disease: a 3-year follow-up study of cases treated with 3 different techniques of bone regeneration. PMID:11759861 | 2001 | this review only | Bone formation (mm); Success rate; Complications | not extracted yet |
| Kim 2002 Long-term results of guided tissue regeneration therapy with non-resorbable and bioabsorbable barriers. II. A case series of infrabony… PMID:11990447 | 2002 | this review only | Success rate; Complications | not extracted yet |
| Majzoub 1999 Guided bone regeneration using demineralized laminar bone sheets versus GTAM membranes in the treatment of implant-associated defects. A… PMID:10551065 | 1999 | this review only | not stated | not extracted yet |
| Mandarino 2018 Alveolar ridge preservation using a non-resorbable membrane: randomized clinical trial with biomolecular analysis. PMID:30954146 | 2018 | this review only | not stated | not extracted yet |
| Merli 2014 Bone level variation after vertical ridge augmentation: resorbable barriers versus titanium-reinforced barriers. A 6-year double-blind… PMID:25032771 | 2014 | this review only | Success rate; Complications | not extracted yet |
| Naenni 2017 Randomized clinical study assessing two membranes for guided bone regeneration of peri-implant bone defects: clinical and histological… PMID:27659296 | 2017 | this review only | Bone formation (mm); Success rate; Complications | not extracted yet |
| Naenni 2021 Implants sites with concomitant bone regeneration using a resorbable or non-resorbable membrane result in stable marginal bone levels and… PMID:33977571 | 2021 | this review only | Success rate; Complications | not extracted yet |
| Scott 1997 Comparison of bioabsorbable laminar bone membrane and non-resorbable ePTFE membrane in mandibular furcations. PMID:9249640 | 1997 | this review only | not stated | not extracted yet |
| Silvestri 2000 Comparison of treatments of infrabony defects with enamel matrix derivative, guided tissue regeneration with a nonresorbable membrane and… PMID:10959787 | 2000 | this review only | not stated | not extracted yet |
| Strauss 2025 Hard and soft tissue contour changes following simultaneous guided bone regeneration at single peri-implant dehiscence defects using… PMID:40199760 | 2025 | this review only | Bone formation (mm) | not extracted yet |
| Vaibhav 2021 Osseointegration of Dental Implants in Ridges with Insufficient Bones using Different Membranes for Guided Bone Regeneration. PMID:34447081 | 2021 | this review only | Bone formation (mm); Success rate; Complications | not extracted yet |
| Van der Zee 2004 Effect of GBR and fixture installation on gingiva and bone levels at adjacent teeth. PMID:14731178 | 2004 | this review only | Success rate | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Effect of intraarticular drug injection in patients with temporomandibular joint disorders with limited mouth opening: a system review and… (2025) | 1 | 0.02 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients undergoing guided bone regeneration (GBR) procedures with membranes | Patients undergoing GBR for infrabony, furcation, post-extraction and peri-implant defects (25 RCTs, n=684 patients) |
| Intervention | Resorbable membranes for GBR | e-PTFE (non-resorbable) membrane (meta-analyses); also d-PTFE, Ti-PTFE and titanium mesh in included RCTs |
| Comparison | Non-resorbable membranes for GBR (or a control group) | Collagen membrane (n=9 RCTs in meta-analysis); polyglactin 910 (n=2); polylactide/polyglycolide (n=2) |
| Outcomes | Efficacy: success rate of bone regeneration (new bone formation, graft stability); failures: membrane exposure, graft loss, infections; clinical complications: inflammation, undesirable bone resorption, need for reoperation | Bone formation (mm) (n=5 RCTs); success rate (n=9, 2, 2 RCTs); complications (n=9, 2 RCTs) |
| Study designs | RCTs; clinical studies with comparisons between membranes or control groups | RCTs (n=25) |
| Timing | Not specified | Follow-up 4 to 168 months |