Non-Cochrane · aetiology · PM41598519
Relationship Between Anemia and Oral Lichen Planus: New Therapeutic Perspectives Based on Anemia Management-A Systematic Review and Meta-Analysis.
Egido-Moreno Sonia, Valls-Roca-Umbert Joan, Schemel-Suárez Mayra, et al. · Journal of clinical medicine · 2026 · PubMed · doi:10.3390/jcm15020581
Findings
7 findings
| Population | ||||
|---|---|---|---|---|
| Adults with oral lichen planus (OLP) | Presence of OLP | Healthy adults without OLP | Anemia (prevalence) | OR 2.52 [1.59, 3.97] GRADE not reported 2 studies · 745 participants |
| Adults with oral lichen planus (OLP) | Presence of OLP | Healthy adults without OLP | Iron deficiency (prevalence) | OR 4.36 [2.86, 6.67] GRADE not reported 3 studies · 905 participants |
| Adults with oral lichen planus (OLP) | Presence of OLP | Healthy adults without OLP | Serum iron concentration | MD -17.53 [-28.18, -6.88] GRADE not reported 3 studies · 1363 participants |
| Adults with oral lichen planus (OLP) | Presence of OLP | Healthy adults without OLP | Serum vitamin B12 concentration | MD -91.38 [-218.22, 35.47] GRADE not reported 5 studies · 1877 participants |
| Adults with oral lichen planus (OLP) | Presence of OLP | Healthy adults without OLP | Serum folic acid concentration | MD -4.28 [-7.83, -0.74] GRADE not reported 4 studies · 1910 participants |
| Adult men with OLP | Presence of OLP | Healthy men without OLP | Hemoglobin concentration Men | MD -0.11 [-1.09, 0.87] GRADE not reported 2 studies · 1638 participants |
| Adult women with OLP | Presence of OLP | Healthy women without OLP | Hemoglobin concentration Women | MD -0.68 [-0.79, -0.57] GRADE not reported 2 studies · 1638 participants |
Included primary studies 11
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Bao 2020 The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study. PMID:32912209 | 2020 | this review only | Anemia (prevalence); Iron deficiency (prevalence); Serum folic acid concentration; Serum vitamin B12 concentration; Serum iron concentration; Hemoglobin concentration | not extracted yet |
| Naik 2020 Reduced levels of serum vitamin B12 in symptomatic cases of oral lichen planus: A cross-sectional study. PMID:32939337 | 2020 | this review only | Serum vitamin B12 concentration; Serum iron concentration | not extracted yet |
| Rashed 2017 Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus. PMID:28463405 | 2017 | this review only | Serum folic acid concentration; Serum vitamin B12 concentration | not extracted yet |
| Rezazadeh 2021 Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran. PMID:33708994 | 2021 | this review only | Serum vitamin B12 concentration; Serum iron concentration | not extracted yet |
| Sahebjamee 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Tar 2025 Effects of Comorbid Disease Improvement on Oral Lichen Planus (OLP) and Oral Leukoplakia (OL) Lesions: A Retrospective Longitudinal Study. PMID:40429402 | 2025 | this review only | Anemia (prevalence); Iron deficiency (prevalence) | not extracted yet |
| Thongprasom 2001 Folate and vitamin B12 levels in patients with oral lichen planus, stomatitis or glossitis. PMID:11944731 | 2001 | this review only | Serum folic acid concentration; Serum vitamin B12 concentration; Serum iron concentration | not extracted yet |
| Tiwari 2016 Assessment of serum copper, iron and immune complexes in potentially malignant disorders and oral cancer. PMID:27737355 | 2016 | this review only | Serum iron concentration; PM41598519-P1-O6 | not extracted yet |
| Wu 2014 Oral manifestations and blood profile in patients with iron deficiency anemia. PMID:24388269 | 2014 | this review only | Iron deficiency (prevalence) | not extracted yet |
| Wu 2025 Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in 588 patients with oral lichen… PMID:39873037 | 2025 | this review only | Serum folic acid concentration; Serum vitamin B12 concentration; Serum iron concentration; PM41598519-P1-O6; Hemoglobin concentration | not extracted yet |
| Yao 2025 Application of machine learning for the analysis of peripheral blood biomarkers in oral mucosal diseases: a cross-sectional study. PMID:40348983 | 2025 | this review only | Serum iron concentration; PM41598519-P1-O6 | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adult patients (OLP) | 1,264 OLP patients and 1,331 healthy controls (n=11 studies) |
| Intervention | Oral lichen planus (exposure) | OLP diagnosed clinically and histopathologically (n=11) |
| Comparison | Healthy controls / subjects without OLP | Healthy controls (n=11) |
| Outcomes | Anemia, hemoglobin, iron metabolism parameters, vitamin B12, folic acid (blood samples) | Anemia prevalence (n=2), iron deficiency prevalence (n=3), hemoglobin by sex (n=2), folic acid (n=4), vitamin B12 (n=5), serum iron (n=3) |
| Study designs | Observational studies (cohort, case-control, cross-sectional) | Cross-sectional case-control studies (n=11) |
| Timing | Not specified | Single time point |