Non-Cochrane · intervention · PM41503325
Postoperative Bleeding Complications Associated With Dental Implant Placement in Patients Receiving Antithrombotic Therapy: A Systematic Review and Meta-Analysis.
Fathi Wesam, Alharbi Wejdan H, Al-Zahrani Mohammed A, et al. · Cureus · 2025 · PubMed · doi:10.7759/cureus.98639
Findings
Population Adults on antithrombotic therapy (vitamin K antagonists, DOACs, antiplatelet agents) undergoing dental implant surgery
2 findings
| Continued antithrombotic therapy with local hemostatic measures | Controls not receiving antithrombotic therapy | Postoperative bleeding within three weeks of dental implant placement Within three weeks postoperatively · Dental implant surgery | RR 4.47 [2.35, 8.51] GRADE not reported 8 studies · 1792 participants |
| Continued antithrombotic therapy with local hemostatic measures | Controls not receiving antithrombotic therapy | Postoperative bleeding within three weeks of dental implant placement Within three weeks postoperatively · Dental implant surgery · Sensitivity analysis restricted to studies at low risk of bias (ROBINS-I) | RR 1.61 [0.93, 2.79] GRADE not reported 4 studies · 954 participants |
Included primary studies 29
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Manor 2021 A retrospective analysis of dental implantation under anticoagulant treatment DOI:10.1007/s00784-020-03389-z | 2020 | 1 other review | not stated | not extracted yet |
| Manor 2021 A retrospective analysis of dental implantation under anticoagulant treatment. PMID:32506326 | 2021 | 1 other review | not stated | not extracted yet |
| Bacci 2011 Safety of dental implant surgery in patients undergoing anticoagulation therapy: a prospective case-control study DOI:10.1111/j.1600-0501.2010.01963.x | 2010 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Bacci 2011 Safety of dental implant surgery in patients undergoing anticoagulation therapy: a prospective case-control study. PMID:20946205 | 2011 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Buchbender 2021 A prospective comparative study to assess the risk of postoperative bleeding after dental surgery while on medication with direct oral… DOI:10.1186/s12903-021-01868-7 | 2021 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Buchbender 2021 A prospective comparative study to assess the risk of postoperative bleeding after dental surgery while on medication with direct oral… PMID:34620135 | 2021 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Clemm 2016 Management of anticoagulated patients in implant therapy: a clinical comparative study DOI:10.1111/clr.12732 | 2015 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Clemm 2016 Management of anticoagulated patients in implant therapy: a clinical comparative study. PMID:26592859 | 2016 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Galletti 2020 Implant Placement in Patients under Treatment with Rivaroxaban: A Retrospective Clinical Study DOI:10.3390/ijerph17124607 | 2020 | this review only | not stated | not extracted yet |
| Galletti 2020 Implant Placement in Patients under Treatment with Rivaroxaban: A Retrospective Clinical Study. PMID:32604907 | 2020 | this review only | not stated | not extracted yet |
| Gomez-Moreno 2016 (dabigatran) Dental implant surgery in patients in treatment by dabigatran. PMID:26773272 | 2018 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Gomez-Moreno 2016 (rivaroxaban) Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban DOI:10.1111/clr.12653 | 2015 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Gomez-Moreno 2016 (rivaroxaban) Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban. PMID:26073481 | 2016 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Gomez-Moreno 2018 (dabigatran) Dental implant surgery in patients in treatment by dabigatran DOI:10.1111/clr.12785 | 2016 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Hanken 2016 Postoperative bleeding risk for oral surgery under continued rivaroxaban anticoagulant therapy DOI:10.1007/s00784-015-1627-9 | 2015 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Hanken 2016 Postoperative bleeding risk for oral surgery under continued rivaroxaban anticoagulant therapy. PMID:26498769 | 2016 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Kaura 2022 Assessment of Bleeding in Patients on Antiplatelets Undergoing Dental Implants DOI:10.1007/s12663-021-01510-7 | 2021 | this review only | not stated | not extracted yet |
| Kaura 2022 Assessment of Bleeding in Patients on Antiplatelets Undergoing Dental Implants. PMID:35400896 | 2022 | this review only | not stated | not extracted yet |
| Lee 2025 Analysis of Postoperative Bleeding After Oral Surgery in Patients Receiving Anticoagulants: A Retrospective Study DOI:10.3390/medicina61030425 | 2025 | this review only | not stated | not extracted yet |
| Lee 2025 Analysis of Postoperative Bleeding After Oral Surgery in Patients Receiving Anticoagulants: A Retrospective Study. PMID:40142236 | 2025 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Okamoto 2018 Factors Affecting the Occurrence of Complications in the Early Stages After Dental Implant Placement DOI:10.1097/id.0000000000000753 | 2018 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Okamoto 2018 Factors Affecting the Occurrence of Complications in the Early Stages After Dental Implant Placement: A Retrospective Cohort Study. PMID:29557798 | 2018 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Rubino 2019 Postoperative bleeding associated with antiplatelet and anticoagulant drugs: A retrospective study DOI:10.1016/j.oooo.2019.04.005 | 2019 | this review only | not stated | not extracted yet |
| Rubino 2019 Postoperative bleeding associated with antiplatelet and anticoagulant drugs: A retrospective study. PMID:31103527 | 2019 | this review only | not stated | not extracted yet |
| Sannino 2020 Postoperative bleeding in patients taking oral anticoagulation therapy after 'All-on-four' rehabilitation: A case-control study. PMID:32186289 | 2020 | this review only | Postoperative bleeding within three weeks of dental implant placement | not extracted yet |
| Tabrizi 2018 Do Antiplatelet Drugs Increase the Risk of Bleeding After Dental Implant Surgery? A Case-and-Crossover Study DOI:10.1016/j.joms.2018.04.036 | 2018 | this review only | not stated | not extracted yet |
| Tabrizi 2018 Do Antiplatelet Drugs Increase the Risk of Bleeding After Dental Implant Surgery? A Case-and-Crossover Study. PMID:29928849 | 2018 | this review only | not stated | not extracted yet |
| Zeevi 2017 DOI:10.3290/j.qi.a38103 | NR | this review only | not stated | not extracted yet |
| Zeevi 2017 Four-year cross-sectional study of bleeding risk in dental patients on direct oral anticoagulants. PMID:28439571 | 2017 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Specific gene expression patterns associated as reliable biomarkers for predicting dental implant successful osseointegration: a… (2025) | 2 | 0.02 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults aged 18 years or older on anticoagulant or antiplatelet therapy undergoing dental implant surgery | Adults on vitamin K antagonists, direct oral anticoagulants and antiplatelet agents undergoing implant surgery (15 studies; 3,101 participants) |
| Intervention | Perioperative continuation of antithrombotic therapy with standardized local hemostatic measures | Continued antithrombotic therapy (n=15 studies; one study with discontinuation comparison) |
| Comparison | Healthy controls without antithrombotic therapy matched for age and procedure type | Controls without antithrombotic therapy (8 studies in primary meta-analysis; 1,332 controls) |
| Outcomes | Postoperative bleeding within three weeks (minor, moderate, severe); impact of anticoagulant class and procedural complexity | Postoperative bleeding (pooled RR, 8 studies); bleeding rates by drug class (narrative) |
| Study designs | RCTs, prospective or retrospective cohorts, case-control and cross-sectional studies, published 2011 to 2025 | 15 observational studies (prospective and retrospective cohorts, case-control, cross-sectional); no RCTs |
| Timing | Postoperative bleeding within three weeks | Postoperative bleeding follow-up, not pooled by timepoint |