Non-Cochrane · prognostic · PM41039851
The Risk of Preterm Birth in Women With Periodontitis: A Systematic Review and Meta-Analysis.
Sokos Dimitris, Slot Dagmar Else, Dogan Berna, et al. · International journal of dental hygiene · 2026 · PubMed · doi:10.1111/idh.70001
Findings
Population Pregnant women
25 findings
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Country socio-economic status: developed | OR 1.61 [1.25, 2.07] GRADE not reported 4 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Study design: case-control | OR 2.86 [1.73, 4.72] GRADE not reported 4 studies · 2472 participants |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Studies including smokers | OR 2.50 [1.74, 3.59] GRADE not reported 8 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Periodontitis definition: >=4 mm CAL | OR 2.15 [1.44, 3.21] GRADE not reported 2 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Periodontitis definition: >=4 teeth with PPD >=4 mm and CAL >=3 mm at the same site | OR 2.86 [1.79, 4.56] GRADE not reported 5 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Study design: cohort | OR 2.07 [1.48, 2.89] GRADE not reported 6 studies · 3436 participants |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Periodontitis definition: PPD >3 mm | OR 2.43 [1.68, 3.52] GRADE not reported 8 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Periodontitis definition: PPD >2 mm | OR 2.87 [1.65, 4.99] GRADE not reported 2 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Studies excluding participants with co-morbidities | OR 2.53 [1.45, 4.42] GRADE not reported 6 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery | OR 2.38 [1.78, 3.18] Moderate 11 studies · 5978 participants |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Periodontitis definition: >=2 affected teeth | OR 2.31 [1.60, 3.34] GRADE not reported 3 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Country socio-economic status: developing | OR 3.08 [2.22, 4.26] GRADE not reported 7 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Studies including participants with history of urinary tract infection | OR 2.38 [1.63, 3.49] GRADE not reported 7 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Continent: South America | OR 4.03 [2.71, 6.00] GRADE not reported 3 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Examined teeth: full mouth excluding third molars | OR 1.96 [1.50, 2.56] GRADE not reported 5 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Studies excluding smokers | OR 1.71 [0.96, 3.05] GRADE not reported 2 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Periodontitis definition: >=1 affected tooth | OR 1.63 [1.16, 2.31] GRADE not reported 2 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Continent: North America | OR 2.27 [1.82, 2.84] GRADE not reported 3 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Risk of bias: low | OR 2.49 [1.82, 3.42] GRADE not reported 9 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Continent: Europe | OR 1.77 [1.28, 2.44] GRADE not reported 3 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Periodontitis definition: >=3 mm CAL | OR 2.50 [1.60, 3.90] GRADE not reported 6 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Periodontitis definition: >=1 mm CAL | OR 2.87 [1.65, 4.99] GRADE not reported 2 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Examined teeth: full mouth without specification on third molars | OR 2.77 [1.72, 4.44] GRADE not reported 6 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Studies including participants with co-morbidities | OR 2.16 [1.54, 3.03] GRADE not reported 4 studies |
| Periodontitis (exposure) | No periodontitis | Preterm birth (<37 weeks) Delivery · Risk of bias: high | OR 1.60 [0.75, 3.44] GRADE not reported 2 studies |
Included primary studies 11
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Agueda 2008 Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort study. PMID:18034850 | 2008 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Caneiro 2020 Periodontitis as a Preterm Birth Risk Factor in Caucasian Women: A Cohort Study. PMID:32051974 | 2020 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Kumar 2013 Association of maternal periodontal health with adverse pregnancy outcome. PMID:22845916 | 2013 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Lopez 2002 Higher risk of preterm birth and low birth weight in women with periodontal disease. PMID:11820369 | 2002 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Macedo 2014 Periodontal disease and oral health-related behavior as factors associated with preterm birth: a case-control study in south-eastern Brazil. PMID:23947938 | 2014 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Martinez de Tejada 2012 Association between early preterm birth and periodontitis according to USA and European consensus definitions. PMID:22548257 | 2012 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Martinez-Martinez 2016 Association between periodontitis, periodontopathogens and preterm birth: is it real? PMID:26576767 | 2016 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Offenbacher 2001 Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction. PMID:11887460 | 2001 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Perez-Molina 2019 Enfermedad periodontal como factor de riesgo adicional asociado con nacimiento pretérmino en México: un estudio de casos y controles. PMID:31056598 | 2019 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Piscoya 2012 Maternal periodontitis as a risk factor for prematurity. PMID:22044450 | 2012 | this review only | Preterm birth (<37 weeks) | not extracted yet |
| Pockpa 2022 Association Between Periodontitis and Preterm Birth in a Cohort of Pregnant Women in Ivory Coast. PMID:36259439 | 2022 | this review only | Preterm birth (<37 weeks) | not extracted yet |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Pregnant women | Pregnant women (n=5978) |
| Intervention | Periodontitis defined by full-mouth clinical examination (PPD with CAL and/or radiographic bone loss) | Periodontitis (n=2292) |
| Comparison | Pregnant women without periodontitis | No periodontitis (n=3686) |
| Outcomes | Preterm birth (<37 weeks, confirmed by a health care professional) | Preterm birth (1304 events) |
| Study designs | Observational studies: cohort, case-control, cross-sectional | 6 cohort, 4 case-control, 1 cross-sectional (n=11) |
| Timing | Not specified | Not specified |