Cochrane · systematic review · CD013658
Oncoplastic breast‐conserving surgery for women with primary breast cancer
Nanda, A, Hu, J, Hodgkinson, S, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 8 · 38.1%Very low 10 · 47.6%Low 3 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any O‐BCS compared to S‐BCS for women with primary breast cancer
Population: women with primary breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local recurrence‐free survival (up to 5 years) Any O‐BCS vs S‐BCS | HR 0.9 [0.61, 1.34] | 4 studies · 7600 participants | Very low Downgraded: risk of bias, imprecision |
Local recurrence rates (up to 5 years) Any O‐BCS vs S‐BCS | HR 1.33 [0.96, 1.83] | 4 studies · 2443 participants | Low Downgraded: risk of bias, imprecision |
Disease‐free survival (up to 5 years) Any O‐BCS vs S‐BCS | HR 1.06 [0.89, 1.26] | 7 studies · 5532 participants | Low Downgraded: risk of bias, imprecision |
Re‐excision rate: total re‐excisions Any O‐BCS vs S‐BCS | RR 0.76 [0.69, 0.85] | 38 studies · 13341 participants | Very low Downgraded: risk of bias, inconsistency, publication bias |
Complications Any O‐BCS vs S‐BCS | RR 1.19 [1.1, 1.27] | 20 studies · 118005 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Recall rate Any O‐BCS vs S‐BCS | RR 2.39 [1.67, 3.42] | 6 studies · 715 participants | Low Downgraded: risk of bias |
Patient‐reported outcome measures Any O‐BCS vs S‐BCS | no estimate extracted | 24 studies · 5665 participants | Very low Downgraded: risk of bias |
Any O‐BCS compared to mastectomy for women with primary breast cancer
Population: women with primary breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local recurrence‐free survival (up to 5 years) Any O‐BCS vs mastectomy | HR 0.55 [0.34, 0.91] | 2 studies · 4713 participants | Very low Downgraded: risk of bias, inconsistency |
Cumulative local recurrence rate Any O‐BCS vs mastectomy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Disease‐free survival Any O‐BCS vs mastectomy | RR 0.58 [0.41, 0.82] | 1 study · 1193 participants | Very low Downgraded: risk of bias, imprecision |
Re‐excision rates Any O‐BCS vs mastectomy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Complications Any O‐BCS vs mastectomy | RR 0.75 [0.67, 0.83] | 4 studies · 4839 participants | Very low Downgraded: risk of bias, inconsistency |
Recall rates Any O‐BCS vs mastectomy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Patient‐reported outcome measures Any O‐BCS vs mastectomy | no estimate extracted | 1 study · 1 participants | Ungraded |
Any O‐BCS compared to mastectomy plus reconstruction for women with primary breast cancer
Population: women with primary breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Local recurrence‐free survival Any O‐BCS vs mastectomy plus reconstruction | HR 1.37 [0.72, 2.62] | 1 study · 3785 participants | Very low Downgraded: risk of bias, imprecision |
Cumulative local recurrence rate Any O‐BCS vs mastectomy plus reconstruction | no estimate extracted | 0 studies · 0 participants | Ungraded |
Disease‐free survival Any O‐BCS vs mastectomy plus reconstruction | HR 0.45 [0.09, 2.22] | 1 study · 317 participants | Very low Downgraded: risk of bias, imprecision |
Re‐excision rates Any O‐BCS vs mastectomy plus reconstruction | no estimate extracted | 0 studies · 0 participants | Ungraded |
Complications Any O‐BCS vs mastectomy plus reconstruction | RR 0.49 [0.45, 0.54] | 5 studies · 4973 participants | Very low Downgraded: risk of bias, inconsistency |
Recall rates Any O‐BCS vs mastectomy plus reconstruction | no estimate extracted | 0 studies · 0 participants | Ungraded |
Patient‐reported outcome measures Any O‐BCS vs mastectomy plus reconstruction | no estimate extracted | 3 studies · 3 participants | Ungraded |