Cochrane · systematic review · CD013392
Early fortification of human milk versus late fortification to promote growth in preterm infants
Thanigainathan, S, Abiramalatha, T · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early versus late fortification of human milk in preterm infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to regain birth weight (days) Early vs late fortification of human milk | no estimate extracted | 2 studies · 237 participants | Low Downgraded: risk of bias, imprecision |
Linear growth (cm/week) Early vs late fortification of human milk | no estimate extracted | 2 studies · 237 participants | Low Downgraded: risk of bias, imprecision |
Increase in head circumference (cm/week) Early vs late fortification of human milk | no estimate extracted | 2 studies · 237 participants | Low Downgraded: risk of bias, imprecision |
Necrotising enterocolitis stage 2 or 3 Early vs late fortification of human milk | RR 1.36 [0.44, 4.16] | 2 studies · 237 participants | Low Downgraded: risk of bias, imprecision |
Time to reach full enteral feeds Early vs late fortification of human milk | no estimate extracted | 2 studies · 237 participants | Low Downgraded: risk of bias, imprecision |
Extrauterine growth restriction at discharge Early vs late fortification of human milk | RR 1.06 [0.81, 1.39] | 2 studies · 237 participants | Low Downgraded: risk of bias, imprecision |
Proportion of infants with feed interruption episodes Early vs late fortification of human milk | RR 0.99 [0.73, 1.34] | 2 studies · 237 participants | Low Downgraded: risk of bias, imprecision |