Cochrane · systematic review · CD013359

Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children

Kay, AW, Ness, T, Verkuijl, SE, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library

Infectious Diseases2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 2 · 28.6%Ungraded 0 · 0%Very low 2 · 28.6%Low 0 · 0%Moderate 2 · 28.6%High 1 · 14.3%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Xpert Ultra for pulmonary tuberculosis in childrena

Population: children with presumed pulmonary tuberculosis Index tests: Xpert Ultra Role: an initial test Threshold for index tests: an automated result is provided Reference standard: culture Types of studies: cross‐sectional and cohort studies

CD013359.PUB3 (current) · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Specimen	no estimate extracted	NR	No studies
Sputum	no estimate extracted	5 studies · 127 participants	High
Gastric aspirate	no estimate extracted	7 studies · 120 participants	Moderate Downgraded: imprecision
Stool	no estimate extracted	6 studies · 200 participants	Moderate Downgraded: imprecision
Nasopharyngeal aspirate	no estimate extracted	4 studies · 46 participants	Very low Downgraded: imprecision, indirectness

Xpert Ultra for rifampicin resistancea

Population: children with presumed pulmonary tuberculosis Index tests: Xpert Ultra Role: an initial test Threshold for index tests: an automated result is provided Reference standard: culture‐based phenotypic drug susceptibility testing and MTBDRplus Types of studies: cross‐sectional and cohort studies

CD013359.PUB3 (current) · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Specimen	no estimate extracted	NR	No studies
All specimens	no estimate extracted	3 studies · 3 participants	Very low Downgraded: risk of bias, imprecision, indirectness

Xpert MTB/RIF and Xpert Ultra for pulmonary tuberculosis in children

Population: children with presumed pulmonary tuberculosis

CD013359.PUB2 · 3 questions

Outcome	Effect	Evidence	Status / GRADE
Index test	no estimate extracted	NR	No studies
Xpert MTB/RIF	no estimate extracted	23 studies · 493 participants	Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness
Xpert Ultra	no estimate extracted	3 studies · 136 participants	Low Downgraded: risk of bias, imprecision, inconsistency, indirectness

Xpert MTB/RIF for tuberculous meningitis in children

Population: children with presumed tuberculous meningitis

CD013359.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Test result	no estimate extracted	NR	No studies
True‐positives	no estimate extracted	6 studies · 28 participants	Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness
False‐negatives	no estimate extracted	6 studies · 28 participants	Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness
True‐negatives	no estimate extracted	6 studies · 213 participants	Low Downgraded: risk of bias, imprecision, inconsistency, indirectness
False‐positives	no estimate extracted	6 studies · 213 participants	Low Downgraded: risk of bias, imprecision, inconsistency, indirectness

Xpert MTB/RIF for lymph node tuberculosis in children

Population: children with presumed lymph node tuberculosis

CD013359.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Test result	no estimate extracted	NR	No studies
True‐positives	no estimate extracted	6 studies · 68 participants	Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness
False‐negatives	no estimate extracted	6 studies · 68 participants	Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness
True‐negatives	no estimate extracted	6 studies · 142 participants	Low Downgraded: risk of bias, imprecision, inconsistency, indirectness
False‐positives	no estimate extracted	6 studies · 142 participants	Low Downgraded: risk of bias, imprecision, inconsistency, indirectness

Xpert MTB/RIF for rifampicin resistance in children

Population: children with presumed tuberculosis

CD013359.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Test result	no estimate extracted	NR	No studies
True‐positives	no estimate extracted	6 studies · 20 participants	Low Downgraded: imprecision, inconsistency
False‐negatives	no estimate extracted	6 studies · 20 participants	Low Downgraded: imprecision, inconsistency
True‐negatives	no estimate extracted	6 studies · 203 participants	Moderate Downgraded: imprecision, inconsistency
False‐positives	no estimate extracted	6 studies · 203 participants	Moderate Downgraded: imprecision, inconsistency