Cochrane · systematic review · CD013359
Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children
Kay, AW, Ness, T, Verkuijl, SE, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 2 · 28.6%Low 0 · 0%Moderate 2 · 28.6%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsXpert Ultra for pulmonary tuberculosis in childrena
Population: children with presumed pulmonary tuberculosis Index tests: Xpert Ultra Role: an initial test Threshold for index tests: an automated result is provided Reference standard: culture Types of studies: cross‐sectional and cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Specimen | no estimate extracted | NR | No studies |
Sputum | no estimate extracted | 5 studies · 127 participants | High |
Gastric aspirate | no estimate extracted | 7 studies · 120 participants | Moderate Downgraded: imprecision |
Stool | no estimate extracted | 6 studies · 200 participants | Moderate Downgraded: imprecision |
Nasopharyngeal aspirate | no estimate extracted | 4 studies · 46 participants | Very low Downgraded: imprecision, indirectness |
Xpert Ultra for rifampicin resistancea
Population: children with presumed pulmonary tuberculosis Index tests: Xpert Ultra Role: an initial test Threshold for index tests: an automated result is provided Reference standard: culture‐based phenotypic drug susceptibility testing and MTBDRplus Types of studies: cross‐sectional and cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Specimen | no estimate extracted | NR | No studies |
All specimens | no estimate extracted | 3 studies · 3 participants | Very low Downgraded: risk of bias, imprecision, indirectness |