Cochrane · systematic review · CD013290
Perioperative systemic nonsteroidal anti‐inflammatory drugs (NSAIDs) in women undergoing breast surgery
Klifto, KM, Elhelali, A, Payne, RM, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 35.7%Low 8 · 57.1%Moderate 1 · 7.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
NSAID compared to placebo in women undergoing breast surgery
Population: women undergoing breast surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of breast hematoma NSAID vs placebo | RR 0.33 [0.05, 2.02] | 2 studies · 230 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Pain intensity 24 (± 12) hours following surgery NSAID vs placebo | no estimate extracted | 3 studies · 310 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Incidence rate or severity of postoperative nausea, vomiting, or both NSAID vs placebo | RR 1.15 [0.58, 2.27] | 4 studies · 939 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Bleeding from any location within 90 days NSAID vs placebo | RR 1.05 [0.89, 1.24] | 2 studies · 251 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Need for blood transfusion NSAID vs placebo | RR 4.62 [0.23, 91.34] | 1 study · 48 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other side effects of NSAID use NSAID vs placebo | RR 1.12 [0.44, 2.86] | 2 studies · 251 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Opioid use within 24 (± 12) hours of surgery NSAID vs placebo | no estimate extracted | 4 studies · 304 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
NSAID compared to other analgesic in women undergoing breast surgery
Population: women undergoing breast surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of breast hematoma within 90 days of breast surgery NSAID vs other analgesic | RR 0.33 [0.01, 7.99] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Pain intensity 24 (± 12) hours following surgery NSAID vs other analgesic | no estimate extracted | 3 studies · 200 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Incidence rate or severity of postoperative nausea, vomiting, or both NSAID vs other analgesic | RR 0.18 [0.06, 0.57] | 3 studies · 128 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Bleeding from any location within 90 days NSAID vs other analgesic | RR 0.33 [0.01, 7.99] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other side effects of NSAID use NSAID vs other analgesic | RR 0.11 [0.01, 1.8] | 1 study · 48 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Opioid use within 24 (± 12) hours of surgery NSAID vs other analgesic | no estimate extracted | 3 studies · 178 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
NSAID compared to no intervention in women undergoing breast surgery
Population: women undergoing breast surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity 24 (±12) hours following surgery NSAID vs no intervention | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |