Cochrane · systematic review · CD013133
Indomethacin for symptomatic patent ductus arteriosus in preterm infants
Evans, P, O'Reilly, D, Flyer, JN, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 2 · 28.6%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Indomethacin compared to placebo or control for symptomatic patent ductus arteriosus in preterm infants
Population: symptomatic patent ductus arteriosus in preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Failure of PDA closure within 1 week of administration of the first dose of indomethacin Indomethacin vs placebo or control | RR 0.3 [0.23, 0.38] | 10 studies · 654 participants | High |
Bronchopulmonary dysplasia at 28 days Indomethacin vs placebo or control | RR 1.45 [0.6, 3.51] | 1 study · 55 participants | Low Downgraded: imprecision |
Bronchopulmonary dysplasia at 36 weeks' gestation Indomethacin vs placebo or control | RR 0.8 [0.41, 1.55] | 1 study · 92 participants | Low Downgraded: imprecision |
All‐cause neonatal mortality before hospital discharge Indomethacin vs placebo or control | RR 0.78 [0.46, 1.33] | 8 studies · 314 participants | Moderate Downgraded: imprecision |
Proportion of infants requiring surgical ligation of PDA Indomethacin vs placebo or control | RR 0.66 [0.33, 1.29] | 7 studies · 275 participants | Moderate Downgraded: imprecision |
NEC (≥ Bell stage 2) Indomethacin vs placebo or control | RR 1.27 [0.36, 4.55] | 2 studies · 147 participants | Low Downgraded: imprecision |
Mucocutaneous or gastrointestinal bleeding Indomethacin vs placebo or control | RR 0.33 [0.01, 7.58] | 2 studies · 119 participants | Low Downgraded: imprecision |