Cochrane · systematic review · CD013084
Intravenous iron therapy for non‐anaemic, iron‐deficient adults
Miles, LF, Litton, E, Imberger, G, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intravenous iron compared to placebo for non‐anaemic, iron‐deficient adults
Population: non‐anaemic, iron‐deficient adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Haemoglobin concentration taken at the end of Intravenous iron vs placebo | no estimate extracted | 8 studies · 548 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Overall quality of life measured at the end of Intravenous iron vs placebo | no estimate extracted | 3 studies · 344 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serum ferritin concentration measured at the end of Intravenous iron vs placebo | no estimate extracted | 7 studies · 376 participants | Very low Downgraded: imprecision, inconsistency |
Bacterial infection Intravenous iron vs placebo | no estimate extracted | NR | No studies |
Peak oxygen consumption taken at the end of Intravenous iron vs placebo | no estimate extracted | 2 studies · 32 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events Intravenous iron vs placebo | no estimate extracted | NR | No studies |
Mild adverse effects Intravenous iron vs placebo | RR 1.19 [0.97, 1.45] | 3 studies · 440 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |