Cochrane · systematic review · CD013066
Citicoline for treating people with acute ischemic stroke
Martí-Carvajal, AJ, Valli, C, Martí-Amarista, CE, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
StrokeAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Citicoline compared with placebo or standard treatment for treating people with acute ischemic stroke
Population: people with acute ischemic stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality (at any time of trial) Citicoline vs placebo or standard treatment | RR 0.94 [0.83, 1.07] | 8 studies · 4362 participants | Low Downgraded: risk of bias |
Disability or dependence in daily activities Patients with moderate or lower degree of disability or dependence (according to < 3 scores in the modified Rankin scale) lower scores indicate better outcome Citicoline vs placebo or standard treatment | RR 1.11 [0.97, 1.26] | 4 studies · 3668 participants | Low Downgraded: risk of bias |
Severe adverse events Citicoline vs placebo or standard treatment | RR 1.12 [1, 1.26] | 3 studies · 3591 participants | Low Downgraded: risk of bias, imprecision |
Functional recoveryPatients with scores in the Barthel Index ≥ 95 points Citicoline vs placebo or standard treatment | RR 1.03 [0.94, 1.13] | 4 studies · 3850 participants | Low Downgraded: risk of bias |
Neurological functionPatients with minor impairment (according to ≤ 1 scores in the National Institutes of Health Stroke Scale) Citicoline vs placebo or standard treatment | RR 1.08 [0.96, 1.21] | 5 studies · 3950 participants | Low Downgraded: risk of bias |
Quality of life (at the time of Citicoline vs placebo or standard treatment | no estimate extracted | NR | No studies |