Cochrane · systematic review · CD013038
Exposure to the smell and taste of milk to accelerate feeding in preterm infants
Delgado Paramo, L, Bronnert, A, Lin, L, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 2 · 28.6%Low 2 · 28.6%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyExposure versus no exposure to the smell and taste of milk with tube feeds in preterm infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to reach full sucking feeds (time to removal of the feeding tube) Exposure vs no exposure to the smell and taste of milk with tube feeds | no estimate extracted | 3 studies · 662 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects related to intervention Exposure vs no exposure to the smell and taste of milk with tube feeds | no estimate extracted | 2 studies · 2 participants | Ungraded |
Duration of parenteral nutrition (time to removal of IV nutrition line) Exposure vs no exposure to the smell and taste of milk with tube feeds | no estimate extracted | 3 studies · 977 participants | Low Downgraded: risk of bias, imprecision |
Time to reach full enteral feeds (150 mL/kg/day or as defined by the trialists) Exposure vs no exposure to the smell and taste of milk with tube feeds | no estimate extracted | 4 studies · 736 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Feeding intolerance during hospitalisation (resulting in discontinuation of or reduction in enteral feeding) Exposure vs no exposure to the smell and taste of milk with tube feeds | no estimate extracted | 0 studies · 0 participants | Ungraded |
Necrotising enterocolitis during hospitalisation (Bell's stage ≥ 2) Exposure vs no exposure to the smell and taste of milk with tube feeds | RR 0.93 [0.47, 1.84] | 2 studies · 435 participants | Low Downgraded: imprecision |
Late infection during hospitalisation (bacterial or fungal infection confirmed by presence of blood or CSF infection, with initiation of symptoms > 48 hours after birth) Exposure vs no exposure to the smell and taste of milk with tube feeds | RR 1.14 [0.74, 1.75] | 2 studies · 436 participants | Moderate Downgraded: imprecision |
Exposure to the smell and taste of milk with tube feeds compared to no exposure in preterm infants
Population: preterm infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to reach full sucking feeds (days) Exposure to the smell and taste of milk with tube feeds vs no exposure | no estimate extracted | 2 studies · 131 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse effects related to intervention ‐ not reported Exposure to the smell and taste of milk with tube feeds vs no exposure | no estimate extracted | 1 study · 51 participants | Very low Downgraded: imprecision, indirectness |
Time to reach full enteral feedings (days) Exposure to the smell and taste of milk with tube feeds vs no exposure | no estimate extracted | 1 study · 51 participants | Very low Downgraded: risk of bias, imprecision |
Duration of parenteral nutrition (days) Exposure to the smell and taste of milk with tube feeds vs no exposure | no estimate extracted | 1 study · 51 participants | Very low Downgraded: risk of bias, imprecision |
Necrotising enterocolitis Exposure to the smell and taste of milk with tube feeds vs no exposure | RR 0.62 [0.15, 2.48] | 1 study · 51 participants | Low Downgraded: imprecision |
Late infection Exposure to the smell and taste of milk with tube feeds vs no exposure | RR 2.46 [0.27, 22.13] | 1 study · 51 participants | Low Downgraded: imprecision |
Time to first discharge home (days) Exposure to the smell and taste of milk with tube feeds vs no exposure | no estimate extracted | 2 studies · 131 participants | Very low Downgraded: risk of bias, imprecision, indirectness |