Cochrane · systematic review · CD012940

Re‐feeding versus discarding gastric residuals to improve growth in preterm infants

Abiramalatha, T, Thanigainathan, S, Ramaswamy, VV, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Neonatal2 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Summary of findings table ‐ Re‐feeding versus discarding gastric residuals in preterm infants

Population: preterm infants
CD012940.PUB3 (current) · 7 questions
OutcomeEffectEvidenceStatus / GRADE
Time to regain birth weight (days)
Summary of findings table ‐ Re‐feeding vs discarding gastric residuals
no estimate extracted1 study · 59 participantsLow
Downgraded: imprecision
Risk of NEC stage ≥ 2 or SIPb,c
Summary of findings table ‐ Re‐feeding vs discarding gastric residuals
RR 0.71 [0.25, 2.04]1 study · 72 participantsLow
Downgraded: imprecision
All‐cause mortality before hospital discharge
Summary of findings table ‐ Re‐feeding vs discarding gastric residuals
RR 0.5 [0.14, 1.85]1 study · 72 participantsLow
Downgraded: imprecision
Time to establish full enteral feeds (120 mL/kg/d)
Summary of findings table ‐ Re‐feeding vs discarding gastric residuals
no estimate extracted1 study · 59 participantsLow
Downgraded: imprecision
Number of infants with feed interruption episodes lasting ≥ 12 hours
Summary of findings table ‐ Re‐feeding vs discarding gastric residuals
RR 0.8 [0.42, 1.52]1 study · 59 participantsVery low
Downgraded: risk of bias, imprecision
Number of TPN days
Summary of findings table ‐ Re‐feeding vs discarding gastric residuals
no estimate extracted1 study · 59 participantsLow
Downgraded: imprecision
Risk of extrauterine growth restriction at discharge
Summary of findings table ‐ Re‐feeding vs discarding gastric residuals
RR 1.29 [0.38, 4.34]1 study · 59 participantsLow
Downgraded: imprecision

Re‐feeding compared to discarding gastric residual in preterm infants

Population: preterm infants
CD012940.PUB2 · 4 questions
OutcomeEffectEvidenceStatus / GRADE
Time to regain birth weight (days)
Re‐feeding vs discarding gastric residual
no estimate extracted1 study · 59 participantsVery low
Downgraded: risk of bias
Number of infants with necrotising enterocolitis stage 2 or 3 and/or spontaneous intestinal perforation
Re‐feeding vs discarding gastric residual
RR 0.71 [0.25, 2.04]1 study · 72 participantsVery low
Downgraded: risk of bias, imprecision
Number of infants with episodes of interruption of feeds ≥ 12 hours
Re‐feeding vs discarding gastric residual
RR 0.8 [0.42, 1.52]1 study · 59 participantsVery low
Downgraded: risk of bias, imprecision
Mortality before discharge
Re‐feeding vs discarding gastric residual
RR 0.5 [0.14, 1.85]1 study · 72 participantsLow
Downgraded: risk of bias, imprecision