Cochrane · systematic review · CD012768

Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults

Kohli, M, Schiller, I, Dendukuri, N, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library

Infectious Diseases2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 8 · 33.3%Ungraded 0 · 0%Very low 8 · 33.3%Low 4 · 16.7%Moderate 4 · 16.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Xpert Ultra and Xpert MTB/RIF in cerebrospinal fluid

CD012768.PUB3 (current) · 6 questions

Outcome	Effect	Evidence	Status / GRADE
Xpert Ultra result	no estimate extracted	NR	No studies
True‐positives (participants with TB meningitis)	no estimate extracted	6 studies · 89 participants	Low Downgraded: imprecision
False‐negatives (participants incorrectly classified as not having TB meningitis)	no estimate extracted	6 studies · 89 participants	Low Downgraded: imprecision
True‐negatives (participants without TB meningitis)	no estimate extracted	6 studies · 386 participants	Moderate Downgraded: imprecision
False‐positives (participants incorrectly classified as having TB meningitis)	no estimate extracted	6 studies · 386 participants	Moderate Downgraded: imprecision
Xpert MTB/RIF result	no estimate extracted	NR	No studies

Xpert Ultra and Xpert MTB/RIF in pleural fluid

CD012768.PUB3 (current) · 6 questions

Outcome	Effect	Evidence	Status / GRADE
Xpert Ultra result	no estimate extracted	NR	No studies
True‐positives (patients with pleural TB)	no estimate extracted	4 studies · 158 participants	Very low Downgraded: imprecision, inconsistency, indirectness
False‐negatives (patients incorrectly classified as not having pleural TB)	no estimate extracted	4 studies · 158 participants	Very low Downgraded: imprecision, inconsistency, indirectness
True‐negatives (patients without pleural TB)	no estimate extracted	4 studies · 240 participants	Very low Downgraded: imprecision, inconsistency, indirectness
False‐positives (patients incorrectly classified as having pleural TB)	no estimate extracted	4 studies · 240 participants	Very low Downgraded: imprecision, inconsistency, indirectness
Xpert MTB/RIF result	no estimate extracted	NR	No studies

Xpert Ultra and Xpert MTB/RIF in lymph node aspirate

CD012768.PUB3 (current) · 6 questions

Outcome	Effect	Evidence	Status / GRADE
Xpert Ultra result	no estimate extracted	NR	No studies
True‐positives (patients with lymph node TB)	no estimate extracted	1 study · 30 participants	Very low Downgraded: risk of bias, imprecision, indirectness
False‐negatives (patients incorrectly classified as not having lymph node TB)	no estimate extracted	1 study · 30 participants	Very low Downgraded: risk of bias, imprecision, indirectness
True‐negatives (patients without lymph node TB)	no estimate extracted	1 study · 43 participants	Very low Downgraded: risk of bias, imprecision, indirectness
False‐positives (patients incorrectly classified as having lymph node TB)	no estimate extracted	1 study · 43 participants	Very low Downgraded: risk of bias, imprecision, indirectness
Xpert MTB/RIF result	no estimate extracted	NR	No studies

Xpert Ultra and Xpert MTB/RIF for rifampicin resistance

CD012768.PUB3 (current) · 6 questions

Outcome	Effect	Evidence	Status / GRADE
Xpert Ultra result	no estimate extracted	NR	No studies
True‐positives (patients correctly classified as rifampicin resistant)	no estimate extracted	4 studies · 24 participants	Low Downgraded: imprecision, indirectness
False‐negatives (patients incorrectly classified as rifampicin susceptible)	no estimate extracted	4 studies · 24 participants	Low Downgraded: imprecision, indirectness
True‐negatives (patients correctly classified as rifampicin susceptible)	no estimate extracted	4 studies · 105 participants	Moderate Downgraded: imprecision, indirectness
False‐positives (patients incorrectly classified as rifampicin resistant)	no estimate extracted	4 studies · 105 participants	Moderate Downgraded: imprecision, indirectness
Xpert MTB/RIF result	no estimate extracted	NR	No studies

Xpert® MTB/RIF in cerebrospinal fluid

CD012768.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Test result	no estimate extracted	NR	No studies
True‐positives (patients with TB meningitis)	no estimate extracted	29 studies · 433 participants	Moderate Downgraded: risk of bias
False‐negatives (patients incorrectly classified as not having TB meningitis)	no estimate extracted	29 studies · 433 participants	Moderate Downgraded: risk of bias
True‐negatives (patients without TB meningitis)	no estimate extracted	29 studies · 3341 participants	High
False‐positives (patients incorrectly classified as having TB meningitis)	no estimate extracted	29 studies · 3341 participants	High

Xpert® MTB/RIF in pleural fluid

CD012768.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Test result	no estimate extracted	NR	No studies
True‐positives (patients with pleural TB)	no estimate extracted	27 studies · 606 participants	Low Downgraded: risk of bias, inconsistency
False‐negatives (patients incorrectly classified as not having pleural TB)	no estimate extracted	27 studies · 606 participants	Low Downgraded: risk of bias, inconsistency
True‐negatives (patients without pleural TB)	no estimate extracted	27 studies · 3399 participants	High
False‐positives (patients incorrectly classified as having pleural TB)	no estimate extracted	27 studies · 3399 participants	High

Xpert® MTB/RIF in urine

CD012768.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Test result	no estimate extracted	NR	No studies
True‐positives (patients with genitourinary TB)	no estimate extracted	13 studies · 73 participants	Moderate Downgraded: risk of bias, imprecision
False‐negatives (patients incorrectly classified as not having genitourinary TB)	no estimate extracted	13 studies · 73 participants	Moderate Downgraded: risk of bias, imprecision
True‐negatives (patients without genitourinary TB)	no estimate extracted	13 studies · 1126 participants	Moderate Downgraded: risk of bias, imprecision
False‐positives (patients incorrectly classified as having genitourinary TB)	no estimate extracted	13 studies · 1126 participants	Moderate Downgraded: risk of bias, imprecision

Xpert® MTB/RIF for rifampicin resistance

CD012768.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Test result	no estimate extracted	NR	No studies
True‐positives (patients correctly classified as rifampicin resistant)	no estimate extracted	20 studies · 148 participants	High
False‐negatives (patients incorrectly classified as rifampicin susceptible)	no estimate extracted	20 studies · 148 participants	High
True‐negatives (patients correctly classified as rifampicin susceptible)	no estimate extracted	39 studies · 1088 participants	High
False‐positives (patients incorrectly classified as rifampicin resistant)	no estimate extracted	39 studies · 1088 participants	High