Cochrane · systematic review · CD012768
Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults
Kohli, M, Schiller, I, Dendukuri, N, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
16
No studies
8
Included studies
NR
No studies 8 · 33.3%Ungraded 0 · 0%Very low 8 · 33.3%Low 4 · 16.7%Moderate 4 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsXpert Ultra and Xpert MTB/RIF in cerebrospinal fluid
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Xpert Ultra result | no estimate extracted | NR | No studies |
True‐positives (participants with TB meningitis) | no estimate extracted | 6 studies · 89 participants | Low Downgraded: imprecision |
False‐negatives (participants incorrectly classified as not having TB meningitis) | no estimate extracted | 6 studies · 89 participants | Low Downgraded: imprecision |
True‐negatives (participants without TB meningitis) | no estimate extracted | 6 studies · 386 participants | Moderate Downgraded: imprecision |
False‐positives (participants incorrectly classified as having TB meningitis) | no estimate extracted | 6 studies · 386 participants | Moderate Downgraded: imprecision |
Xpert MTB/RIF result | no estimate extracted | NR | No studies |
Xpert Ultra and Xpert MTB/RIF in pleural fluid
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Xpert Ultra result | no estimate extracted | NR | No studies |
True‐positives (patients with pleural TB) | no estimate extracted | 4 studies · 158 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
False‐negatives (patients incorrectly classified as not having pleural TB) | no estimate extracted | 4 studies · 158 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
True‐negatives (patients without pleural TB) | no estimate extracted | 4 studies · 240 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
False‐positives (patients incorrectly classified as having pleural TB) | no estimate extracted | 4 studies · 240 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
Xpert MTB/RIF result | no estimate extracted | NR | No studies |
Xpert Ultra and Xpert MTB/RIF in lymph node aspirate
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Xpert Ultra result | no estimate extracted | NR | No studies |
True‐positives (patients with lymph node TB) | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
False‐negatives (patients incorrectly classified as not having lymph node TB) | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
True‐negatives (patients without lymph node TB) | no estimate extracted | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
False‐positives (patients incorrectly classified as having lymph node TB) | no estimate extracted | 1 study · 43 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Xpert MTB/RIF result | no estimate extracted | NR | No studies |
Xpert Ultra and Xpert MTB/RIF for rifampicin resistance
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Xpert Ultra result | no estimate extracted | NR | No studies |
True‐positives (patients correctly classified as rifampicin resistant) | no estimate extracted | 4 studies · 24 participants | Low Downgraded: imprecision, indirectness |
False‐negatives (patients incorrectly classified as rifampicin susceptible) | no estimate extracted | 4 studies · 24 participants | Low Downgraded: imprecision, indirectness |
True‐negatives (patients correctly classified as rifampicin susceptible) | no estimate extracted | 4 studies · 105 participants | Moderate Downgraded: imprecision, indirectness |
False‐positives (patients incorrectly classified as rifampicin resistant) | no estimate extracted | 4 studies · 105 participants | Moderate Downgraded: imprecision, indirectness |
Xpert MTB/RIF result | no estimate extracted | NR | No studies |