Cochrane · systematic review · CD012693
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI)
Ngwenya, O, Lensen, SF, Vail, A, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 9.1%Very low 0 · 0%Low 10 · 90.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyORT‐based algorithm compared to standard starting dose of FSH for women undergoing IVF/ICSI
Population: women undergoing IVF/ICSI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy ORT‐based algorithm vs standard starting dose of FSH | OR 1.12 [0.98, 1.29] | 7 studies · 4400 participants | Low Downgraded: risk of bias, indirectness |
OHSS ORT‐based algorithm vs standard starting dose of FSH | OR 0.74 [0.42, 1.28] | 5 studies · 2724 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Clinical pregnancy ORT‐based algorithm vs standard starting dose of FSH | OR 1.04 [0.91, 1.18] | 7 studies · 4400 participants | Low Downgraded: risk of bias, indirectness |
Anticipated low responders: higher compared to lower dose of FSH for women undergoing IVF/ICSI
Population: women undergoing IVF/ICSI who are anticipated to have a low response to stimulation based on one or more ORT measure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
300/450 IU vs 150 IU Anticipated low responders: higher vs lower dose of FSH | OR 1.2 [0.78, 1.86] | 3 studies · 538 participants | Low Downgraded: risk of bias, imprecision |
400/450 IU vs 300 IU Anticipated low responders: higher vs lower dose of FSH | OR 0.77 [0.19, 3.19] | 1 study · 62 participants | Low Downgraded: risk of bias, imprecision |
IU vs 450 IU Anticipated low responders: higher vs lower dose of FSH | OR 1.33 [0.71, 2.52] | 1 study · 356 participants | Low Downgraded: risk of bias, imprecision |
Anticipated normal responders: higher compared to lower dose of FSH for women undergoing IVF/ICSI
Population: women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IU vs 100 IU Anticipated normal responders: higher vs lower dose of FSH | OR 0.88 [0.57, 1.36] | 2 studies · 522 participants | Low Downgraded: risk of bias, imprecision |
225/200 IU vs 150 IU Anticipated normal responders: higher vs lower dose of FSH | OR 0.98 [0.7, 1.36] | 2 studies · 686 participants | Low Downgraded: risk of bias, imprecision |
IU vs 225 IU Anticipated normal responders: higher vs lower dose of FSH | OR 0.65 [0.32, 1.32] | 1 study · 135 participants | Low Downgraded: risk of bias, imprecision |
IU vs 150 IU Anticipated normal responders: higher vs lower dose of FSH | no estimate extracted | 1 study · 37 participants | Ungraded |
Anticipated high responders: higher compared to lower dose of FSH for women undergoing IVF/ICSI
Population: women undergoing IVF/ICSI who are anticipated to have a hyper‐response to stimulation based on at least one ORT measure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IU vs 100 IU Anticipated high responders: higher vs lower dose of FSH | OR 0.98 [0.66, 1.46] | 1 study · 521 participants | Low Downgraded: risk of bias, imprecision |
ORT‐based algorithm compared to standard dose of FSH for women undergoing IVF/ICSI
Population: women undergoing IVF/ICSI
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy ORT‐based algorithm vs standard dose of FSH | OR 1.04 [0.88, 1.23] | 4 studies · 2823 participants | Moderate Downgraded: risk of bias |
OHSS ORT‐based algorithm vs standard dose of FSH | OR 0.54 [0.14, 1.99] | 3 studies · 1494 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancy ORT‐based algorithm vs standard dose of FSH | OR 0.96 [0.82, 1.13] | 4 studies · 2823 participants | Moderate Downgraded: risk of bias |
Anticipated low‐responders: higher compared to lower dose of FSH for women undergoing IVF/ICSI
Population: women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
300/450 IU vs 150 IU Anticipated low‐responders: higher vs lower dose of FSH | OR 0.71 [0.32, 1.58] | 2 studies · 286 participants | Low Downgraded: risk of bias, imprecision |
400/450 IU vs 300 IU Anticipated low‐responders: higher vs lower dose of FSH | OR 0.77 [0.19, 3.19] | 1 study · 62 participants | Low Downgraded: risk of bias, imprecision |
IU vs 450 IU Anticipated low‐responders: higher vs lower dose of FSH | OR 1.33 [0.71, 2.52] | 1 study · 356 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancy Anticipated low‐responders: higher vs lower dose of FSH | no estimate extracted | NR | No studies |
Anticipated normal‐responders: higher compared to lower dose of FSH for women undergoing IVF/ICSI
Population: women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IU vs 100 IU Anticipated normal‐responders: higher vs lower dose of FSH | OR 0.88 [0.57, 1.36] | 2 studies · 522 participants | Low Downgraded: risk of bias, imprecision |
225/200 IU vs 150 IU Anticipated normal‐responders: higher vs lower dose of FSH | OR 1.03 [0.57, 1.86] | 1 study · 277 participants | Low Downgraded: risk of bias, imprecision |
IU vs 225 IU Anticipated normal‐responders: higher vs lower dose of FSH | OR 0.65 [0.32, 1.32] | 1 study · 135 participants | Low Downgraded: risk of bias, imprecision |
Anticipated high‐responders: higher compared to lower dose of FSH for women undergoing IVF/ICSI
Population: women undergoing IVF/ICSI who are anticipated to have a hyper‐response to stimulation based on at least one ORT measure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IU vs 100 IU Anticipated high‐responders: higher vs lower dose of FSH | OR 0.98 [0.66, 1.46] | 1 study · 521 participants | Low Downgraded: risk of bias, imprecision |