Cochrane · systematic review · CD012631
Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit
Klitgaard, TL, Schjørring, OL, Nielsen, FM, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHigher vs lower FiO2 or targets of arterial oxygenation for adults admitted to the ICU
Population: adults admitted to the ICU
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality: range 1 mo to 1 y Higher vs lower FiO2 or targets of arterial oxygenation | RR 1.01 [0.96, 1.06] | 16 studies · 9408 participants | Very low Downgraded: risk of bias, indirectness |
Proportion of participants with ≥ 1 serious adverse events according to International Conference on Harmonisation Good Clinical Practice: range 3 d to 180 d Higher vs lower FiO2 or targets of arterial oxygenation | RR 1.01 [0.96, 1.06] | 17 studies · 9466 participants | Very low Downgraded: risk of bias, indirectness |
Quality of life (any measure): range 180 d to 1 y Higher vs lower FiO2 or targets of arterial oxygenation | no estimate extracted | 2 studies · 1649 participants | Very low Downgraded: risk of bias, indirectness |
Lung injury diagnosed after randomisation (composite outcome): range 4 d to 23 d Higher vs lower FiO2 or targets of arterial oxygenation | RR 1.08 [0.85, 1.38] | 8 studies · 2048 participants | Very low Downgraded: risk of bias, indirectness |
Myocardial infarction diagnosed after randomisation: range ≤ 90 d Higher vs lower FiO2 or targets of arterial oxygenation | RR 0.77 [0.51, 1.15] | 4 studies · 5002 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Stroke diagnosed after randomisation: range 1 mo to 3 mo Higher vs lower FiO2 or targets of arterial oxygenation | RR 1.08 [0.72, 1.64] | 5 studies · 6110 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Sepsis diagnosed after randomisation: range 28 d to 60 d Higher vs lower FiO2 or targets of arterial oxygenation | RR 1.85 [1.17, 2.93] | 3 studies · 752 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Higher versus lower fraction of inspired oxygen or targets of arterial oxygenation for adults admitted to the ICU
Population: adults admitted to the ICU
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Higher vs lower fraction of inspired oxygen or targets of arterial oxygenation | RR 1.18 [1.01, 1.37] | 4 studies · 1135 participants | Very low Downgraded: risk of bias, imprecision |
Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) Higher vs lower fraction of inspired oxygen or targets of arterial oxygenation | RR 1.13 [1.04, 1.23] | 6 studies · 1234 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life (any valid scale such as the 36‐item Short Form Health Survey (SF‐36)) Higher vs lower fraction of inspired oxygen or targets of arterial oxygenation | no estimate extracted | 0 studies · 0 participants | Ungraded |
Lung injury diagnosed after randomization (composite outcome) Higher vs lower fraction of inspired oxygen or targets of arterial oxygenation | RR 1.03 [0.78, 1.36] | 5 studies · 1167 participants | Very low Downgraded: risk of bias, imprecision |
Acute myocardial infarction diagnosed after randomization Higher vs lower fraction of inspired oxygen or targets of arterial oxygenation | no estimate extracted | 0 studies · 0 participants | Ungraded |
Stroke diagnosed after randomization Higher vs lower fraction of inspired oxygen or targets of arterial oxygenation | no estimate extracted | 0 studies · 0 participants | Ungraded |
Severe sepsis diagnosed after randomization Higher vs lower fraction of inspired oxygen or targets of arterial oxygenation | RR 1.87 [0.93, 3.87] | 1 study · 445 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |