Cochrane · systematic review · CD012412

Protein hydrolysate versus standard formula for preterm infants

Ng, DH, Klassen, JRL, Embleton, ND, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library

Neonatal2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 100%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Hydrolysed compared to non‐hydrolysed formula for feeding preterm infants

Population: feeding preterm infants

CD012412.PUB3 (current) · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Feed intolerance Hydrolysed vs non‐hydrolysed formula	RR 2.71 [0.29, 25]	3 studies · 161 participants	Low
Necrotising enterocolitis Hydrolysed vs non‐hydrolysed formula	RR 1.1 [0.36, 3.34]	5 studies · 385 participants	Low

Hydrolysed compared to non‐hydrolysed formula for feeding preterm infants

Population: feeding preterm infants

CD012412.PUB2 · 2 questions

Outcome	Effect	Evidence	Status / GRADE
Feed intolerance Hydrolysed vs non‐hydrolysed formula	RR 2.71 [0.29, 25]	3 studies · 161 participants	Low
Necrotising enterocolitis Hydrolysed vs non‐hydrolysed formula	RR 1.1 [0.36, 3.34]	5 studies · 385 participants	Low