Cochrane · systematic review · CD011878
Salbutamol for transient tachypnea of the newborn
Moresco, L, Bruschettini, M, Macchi, M, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 5 · 71.4%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySalbutamol versus placebo/no treatment for transient tachypnea of the newborn
Population: patients with transient tachypnea of the newborn
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of oxygen therapy (hours) Salbutamol vs placebo/no treatment | no estimate extracted | 4 studies · 338 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Need for continuous positive airway pressure (yes/no) Salbutamol vs placebo/no treatment | RR 0.73 [0.38, 1.39] | 1 study · 46 participants | Very low Downgraded: risk of bias, imprecision |
Need for mechanical ventilation (yes/no) Salbutamol vs placebo/no treatment | RR 0.6 [0.13, 2.86] | 3 studies · 254 participants | Very low Downgraded: risk of bias, imprecision |
Duration of respiratory support (intermittent positive pressure ventilation or continuous positive airway pressure; hours). Salbutamol vs placebo/no treatment | no estimate extracted | 2 studies · 228 participants | Very low Downgraded: risk of bias, imprecision |
Duration of hospital stay (days) Salbutamol vs placebo/no treatment | no estimate extracted | 4 studies · 338 participants | Low Downgraded: risk of bias, imprecision |
Duration of mechanical ventilation (hours) Salbutamol vs placebo/no treatment | no estimate extracted | NR | No studies |
Pneumothorax (yes/no) Salbutamol vs placebo/no treatment | no estimate extracted | 1 study · 80 participants | Very low Downgraded: risk of bias |
Salbutamol compared to placebo/no treatment for transient tachypnea of the newborn
Population: infants with transient tachypnea of the newborn
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of oxygen therapy (hours) Salbutamol vs placebo/no treatment | no estimate extracted | 1 study · 40 participants | Very low Downgraded: imprecision |
Need for continuous positive airway pressure (yes/no) Salbutamol vs placebo/no treatment | RR 0.73 [0.38, 1.39] | 1 study · 46 participants | Very low Downgraded: imprecision |
Need for mechanical ventilation (yes/no) Salbutamol vs placebo/no treatment | RR 1.5 [0.06, 34.79] | 1 study · 46 participants | Very low Downgraded: imprecision |
Duration of hospital stay (days) Salbutamol vs placebo/no treatment | no estimate extracted | 1 study · 40 participants | Very low Downgraded: imprecision |