Cochrane · systematic review · CD011872
Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies
Siristatidis, CS, Sertedaki, E, Vaidakis, D, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 25%Low 6 · 75%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMetabolomics compared to non metabolomics for embryo quality assessment
Population: Women undergoing IVF/ICSI cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate (Delivery of a live fetus after 20 completed weeks of gestation) Metabolomics vs non metabolomics | OR 0.99 [0.69, 1.44] | 3 studies · 597 participants | Low Downgraded: risk of bias |
Live birth rate or ongoing pregnancy (Delivery of a live fetus after 20 completed weeks of gestation or the presence of a fetal heart on ultrasound scan after 12 weeks) Metabolomics vs non metabolomics | OR 1.02 [0.77, 1.35] | 4 studies · 924 participants | Low Downgraded: risk of bias |
Miscarriage (Loss of pregnancy before 20 completed weeks of gestation) Metabolomics vs non metabolomics | OR 1.18 [0.77, 1.82] | 3 studies · 869 participants | Low Downgraded: risk of bias |
Clinical pregnancy (Presence of a fetal heart on ultrasound scan at seven weeks of gestation) Metabolomics vs non metabolomics | OR 1.11 [0.85, 1.45] | 4 studies · 924 participants | Low Downgraded: risk of bias |
Cancellation (Exclusion of a patient after recruitment) Metabolomics vs non metabolomics | OR 1.78 [1.18, 2.69] | 2 studies · 744 participants | Low Downgraded: risk of bias |
Multiple pregnancy (presence of more than 1 gestational sac) Metabolomics vs non metabolomics | OR 1.5 [0.7, 3.19] | 2 studies · 180 participants | Low Downgraded: risk of bias |
Ectopic pregnancy (a pregnancy in which the fetus develops outside the uterus) Metabolomics vs non metabolomics | OR 3 [0.12, 74.07] | 1 study · 417 participants | Very low Downgraded: risk of bias |
Foetal abnormalities (structural or functional anomalies of the foetus) Metabolomics vs non metabolomics | no estimate extracted | 1 study · 125 participants | Very low Downgraded: risk of bias |
Metabolomics compared to non metabolomics for embryo quality assessment
Population: Women undergoing IVF/ICSI cycles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate or ongoing pregnancy Metabolomics vs non metabolomics | OR 1.11 [0.83, 1.48] | 4 studies · 802 participants | Low Downgraded: risk of bias |
Miscarriage Metabolomics vs non metabolomics | OR 0.96 [0.52, 1.78] | 2 studies · 434 participants | Low Downgraded: risk of bias |
Clinical pregnancy Metabolomics vs non metabolomics | OR 1.22 [0.92, 1.62] | 4 studies · 802 participants | Low Downgraded: risk of bias |
Cancellation Metabolomics vs non metabolomics | OR 1.78 [1.18, 2.69] | 2 studies · 744 participants | Low Downgraded: risk of bias |
Multiple pregnancy Metabolomics vs non metabolomics | OR 1.52 [0.71, 3.23] | 2 studies · 181 participants | Low Downgraded: risk of bias |
Ectopic pregnancy Metabolomics vs non metabolomics | OR 3.37 [0.14, 83.4] | 1 study · 309 participants | Very low Downgraded: risk of bias |
Foetal abnormalities Metabolomics vs non metabolomics | no estimate extracted | 1 study · 125 participants | Very low Downgraded: risk of bias |