Cochrane · systematic review · CD011588
Iron therapy for preoperative anaemia
Ng, O, Keeler, BD, Mishra, A, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
7
No studies
3
Included studies
NR
No studies 3 · 30%Ungraded 0 · 0%Very low 1 · 10%Low 6 · 60%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyIron therapy compared to placebo, no treatment or standard care for preoperative anaemia
Population: people with preoperative anaemia awaiting major surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants who received a blood transfusion Iron therapy vs placebo, no treatment or standard care | RR 1.21 [0.87, 1.7] | 4 studies · 200 participants | Low Downgraded: imprecision |
Any validated measure of quality of life (measured by SF36) Iron therapy vs placebo, no treatment or standard care | no estimate extracted | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision |
Haemoglobin levels at end of preoperative treatment (g/dL) Iron therapy vs placebo, no treatment or standard care | MD 0.63 | 2 studies · 83 participants | Low Downgraded: imprecision |
Haemoglobin levels post‐treatment and surgery (g/dL) Iron therapy vs placebo, no treatment or standard care | MD 0.17 | 2 studies · 86 participants | Low Downgraded: imprecision |
Ferritin at the end of preoperative treatment (ng/mL) Iron therapy vs placebo, no treatment or standard care | MD 149 [25.68, 272.32] | 1 study · 76 participants | Low Downgraded: imprecision |
Intravenous iron therapy compared to oral iron therapy for preoperative anaemia
Population: people with preoperative anaemia awaiting major surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants who received a blood transfusion Intravenous iron therapy vs oral iron therapy | no estimate extracted | NR | No studies |
Any validated measure of quality of life Intravenous iron therapy vs oral iron therapy | no estimate extracted | NR | No studies |
Haemoglobin levels at end of preoperative treatment (g/dL) Intravenous iron therapy vs oral iron therapy | MD 1.23 [0.8, 1.65] | 2 studies · 172 participants | Low Downgraded: risk of bias, imprecision |
Haemoglobin levels post‐treatment and surgery (g/dL) Intravenous iron therapy vs oral iron therapy | no estimate extracted | NR | No studies |
Ferritin preoperatively postintervention (ng/L) Intravenous iron therapy vs oral iron therapy | MD 395.03 [227.72, 562.35] | 2 studies · 151 participants | Low Downgraded: risk of bias, imprecision |
Iron therapy versus placebo or no iron therapy for pre‐operative anaemia
Population: Patients with pre‐operative anaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of patients who received a blood transfusion Iron therapy vs placebo or no iron therapy | RR 0.56 [0.27, 1.18] | 2 studies · 38 participants | Low Downgraded: imprecision |
Amount of blood transfused per patient (in units) Iron therapy vs placebo or no iron therapy | no estimate extracted | 2 studies · 38 participants | Low Downgraded: imprecision |
Post‐operative mortality Iron therapy vs placebo or no iron therapy | no estimate extracted | NR | No studies |
Post‐operative morbidity Iron therapy vs placebo or no iron therapy | no estimate extracted | NR | No studies |
Any validated measure of quality of life Iron therapy vs placebo or no iron therapy | no estimate extracted | NR | No studies |
Haemoglobin levels at end of treatment pre‐op (g/dL) Iron therapy vs placebo or no iron therapy | no estimate extracted | 1 study · 18 participants | Low Downgraded: imprecision |
Iron therapy: Intravenous versus oral administration for pre‐operative anaemia
Population: Patients with pre‐operative anaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of patients who received a blood transfusion Iron therapy: Intravenous vs oral administration | no estimate extracted | NR | No studies |
Amount of blood transfused per patient (in units) Iron therapy: Intravenous vs oral administration | no estimate extracted | NR | No studies |
Post‐operative mortality Iron therapy: Intravenous vs oral administration | no estimate extracted | NR | No studies |
Post‐operative morbidity Iron therapy: Intravenous vs oral administration | no estimate extracted | NR | No studies |
Any validated measure of quality of life Iron therapy: Intravenous vs oral administration | no estimate extracted | NR | No studies |
Haemoglobin levels at end of treatment pre‐op (g/dL) Iron therapy: Intravenous vs oral administration | no estimate extracted | 1 study · 56 participants | Low Downgraded: imprecision |