Cochrane · systematic review · CD010993
Skin‐sparing mastectomy for the treatment of breast cancer
Mota, BS, Bevilacqua, JLB, Barrett, J, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Skin‐sparing mastectomy compared to conventional mastectomy for the treatment of breast cancer
Population: people with a diagnosis of ductal carcinoma in situ (DCIS) or invasive breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival,assessed as time to any death Skin‐sparing mastectomy vs conventional mastectomy | HR 0.41 [0.17, 1.02] | 1306 participants | Very low Downgraded: risk of bias, imprecision |
Local recurrence‐free survival Skin‐sparing mastectomy vs conventional mastectomy | HR 0.82 [0.47, 1.42] | 5690 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Overall complications,assessed using the number of participants with at least one local or systemic complication Skin‐sparing mastectomy vs conventional mastectomy | RR 1.55 [0.97, 2.46] | 677 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Breast reconstruction loss Skin‐sparing mastectomy vs conventional mastectomy | RR 1.79 [0.31, 10.35] | 475 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Skin necrosis Skin‐sparing mastectomy vs conventional mastectomy | RR 1.15 [0.62, 2.12] | 677 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Infection Skin‐sparing mastectomy vs conventional mastectomy | RR 2.04 [0.03, 142.71] | 371 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Hemorrhage Skin‐sparing mastectomy vs conventional mastectomy | RR 1.23 [0.47, 3.27] | 677 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |