Cochrane · systematic review · CD010693
Peroxisome proliferator‐activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack
Liu, J, Wang, L-N · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyPeroxisome proliferator‐activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack
Population: people with stroke or transient ischaemic attack
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence of stroke | RR 0.66 [0.44, 0.99] | 3 studies · 4979 participants | Moderate Downgraded: risk of bias |
Reported adverse events | RD 0.1 | 3 studies · 1044 participants | Low Downgraded: risk of bias, inconsistency |
Serious vascular events | OR 0.8 | 1 study · 984 participants | Low Downgraded: risk of bias, imprecision |
Deaths due to vascular events | no estimate extracted | NR | No studies |
Disability due to vascular events | no estimate extracted | NR | No studies |
Improvement in quality of life | no estimate extracted | NR | No studies |
Insulin sensitivity | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias, imprecision |
Peroxisome proliferator‐activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack
Population: people with stroke or transient ischaemic attack
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence of stroke | RR 0.66 [0.44, 0.99] | 3 studies · 4979 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Reported adverse events | RD 0.1 | 3 studies · 1044 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Serious vascular events | OR 0.8 | 1 study · 984 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Deaths due to vascular events | no estimate extracted | NR | No studies |
Disability due to vascular events | no estimate extracted | NR | No studies |
Improvement in quality of life | no estimate extracted | NR | No studies |
Insulin sensitivity | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Ubiquitin‐proteasome activity in carotid plaques | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Peroxisome proliferator‐activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack
Population: people with stroke or transient ischaemic attack
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence of stroke | RR 0.66 [0.44, 0.99] | 3 studies · 4979 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Reported adverse events | RD 0.1 | 3 studies · 1044 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Serious vascular events | OR 0.8 | 1 study · 984 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Deaths due to vascular events | no estimate extracted | NR | No studies |
Disability due to vascular events | no estimate extracted | NR | No studies |
Improvement in quality of life | no estimate extracted | NR | No studies |
Insulin sensitivity | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Ubiquitin‐proteasome activity in carotid plaques | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Comparison
Population: people with stroke or transient ischaemic attack
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence of stroke | RR 0.52 [0.34, 0.8] | 2 studies · 1103 participants | Low Downgraded: risk of bias |
Reported adverse events | RD 0.1 | 3 studies · 1044 participants | Low Downgraded: risk of bias |
Serious vascular events | OR 0.8 | 1 study · 984 participants | Low Downgraded: risk of bias |
Deaths due to vascular events | no estimate extracted | NR | No studies |
Disability due to vascular events | no estimate extracted | NR | No studies |
Improvement in quality of life | no estimate extracted | NR | No studies |
Insulin sensitivity | no estimate extracted | 1 study · 20 participants | Low Downgraded: risk of bias |
Ubiquitin‐proteasome activity in carotid plaques | no estimate extracted | 1 study · 40 participants | Low Downgraded: risk of bias |