Cochrane · systematic review · CD010593
Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock
Li, D, Li, X, Cui, W, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
2
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Liberal initial fluid versus conservative fluid therapy in adults and children with sepsis or septic shock
Population: adults and children with initial sepsis and septic shocka
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Liberal initial fluid vs conservative fluid therapy | RR 1.38 [1.07, 1.77] | 2 studies · 3288 participants | Moderate Downgraded: risk of bias, imprecision |
Adverse events Liberal initial fluid vs conservative fluid therapy | RR 0.95 [0.6, 1.5] | 1 study · 147 participants | Low Downgraded: risk of bias, imprecision |