Cochrane · systematic review · CD010472
Device‐modified trabeculectomy for glaucoma
Park, J, Rittiphairoj, T, Wang, X, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 3 · 42.9%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyDevice‐modified trabeculectomy compared with standard trabeculectomy for people with open‐angle glaucoma
Population: people with glaucoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative mean IOP at 1 year Device‐modified trabeculectomy vs standard trabeculectomy | no estimate extracted | NR | Low Downgraded: risk of bias |
Postoperative mean change in IOP from baseline to 1 year Device‐modified trabeculectomy vs standard trabeculectomy | MD 2 | NR | Very low Downgraded: risk of bias, imprecision |
Postoperative mean logMAR BCVA at 1 year Device‐modified trabeculectomy vs standard trabeculectomy | no estimate extracted | NR | Low Downgraded: risk of bias |
Postoperative mean visual field change at 1 year Device‐modified trabeculectomy vs standard trabeculectomy | no estimate extracted | NR | No studies |
Quality of life at 1 year Device‐modified trabeculectomy vs standard trabeculectomy | no estimate extracted | NR | No studies |
Proportion of participants who were drop‐free at 1 year Device‐modified trabeculectomy vs standard trabeculectomy | RR 2.04 [0.42, 9.82] | NR | Very low Downgraded: risk of bias, imprecision |
Proportion of participants with endophthalmitis Device‐modified trabeculectomy vs standard trabeculectomy | RR 0.34 [0.01, 8.29] | NR | Very low Downgraded: risk of bias, imprecision |
Summary of findings for Ex‐PRESS
Population: people with open‐angle glaucoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative mean IOP at 1 year | no estimate extracted | NR | Low Downgraded: risk of bias |
Postoperative mean logMAR BCVA at 1 year | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Complication as defined in protocol‐ Hypotony | RR 0.92 [0.63, 1.33] | NR | Very low Downgraded: risk of bias, imprecision |
Shallow/flat anterior chamber | RR 0.72 [0.4, 1.32] | NR | Very low Downgraded: risk of bias, imprecision |
Bleb leakage | RR 1.26 [0.5, 3.2] | NR | Very low Downgraded: risk of bias, imprecision |
Hyphema | RR 0.33 [0.12, 0.94] | NR | Low Downgraded: risk of bias |
Cataract surgery | RR 0.32 [0.14, 0.74] | NR | Low Downgraded: risk of bias |
Summary of findings for Ologen
Population: people with glaucoma, including open‐angle, angle‐closure, and uncontrolled IOP
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative mean IOP at 1 year | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Postoperative mean logMAR BCVA at 1 year | no estimate extracted | NR | No studies |
Complication as defined in protocol‐ Hypotony | RR 0.75 [0.47, 1.19] | NR | Very low Downgraded: risk of bias, imprecision |
Shallow anterior chamber | RR 0.79 [0.32, 1.93] | NR | Very low Downgraded: risk of bias, imprecision |
Bleb leakage | RR 0.85 [0.33, 2.2] | NR | Very low Downgraded: risk of bias, imprecision |
Hyphema | RR 1.46 [0.51, 4.19] | NR | Very low Downgraded: risk of bias, imprecision |
Surgical revision | RR 1.7 [0.38, 7.63] | NR | Very low Downgraded: risk of bias, imprecision |
Summary of findings for amniotic membrane
Population: people with glaucoma, including open‐angle, angle‐closure, uncontrolled IOP, and refractive glaucoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative mean IOP at 1 year | no estimate extracted | NR | Low Downgraded: risk of bias |
Postoperative mean logMAR BCVA at 1 year | no estimate extracted | NR | No studies |
Complications ‐ Hypotony | RR 0.4 [0.17, 0.94] | NR | Low Downgraded: risk of bias, imprecision |
Complications ‐ Shallow anterior chamber | RR 0.47 [0.3, 0.73] | NR | Low Downgraded: risk of bias |
Complications ‐ Bleb leakage | RR 0.28 [0.1, 0.79] | NR | Low Downgraded: risk of bias |
Complications ‐ Hyphema | RR 0.43 [0.14, 1.34] | NR | Very low Downgraded: risk of bias, imprecision |
Complications ‐ Surgical revision | no estimate extracted | NR | No studies |