Cochrane · systematic review · CD009950
Pharmacological treatment for pain in Guillain‐Barré syndrome
Liu, J, Wang, LN, McNicol, ED · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
14
No studies
4
Included studies
NR
No studies 4 · 22.2%Ungraded 0 · 0%Very low 11 · 61.1%Low 3 · 16.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyGabapentin compared with placebo for pain in Guillain‐Barré syndrome
Population: patients with pain in Guillain‐Barré syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with self reported pain relief of 50% or greater (not measured) Gabapentin vs placebo | no estimate extracted | NR | No studies |
Pain score (numerical rating scale of 0 to 10: 0 = no pain, 10 = worst pain) Gabapentin vs placebo | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias |
Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) Gabapentin vs placebo | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias |
Rescue analgesic consumption Gabapentin vs placebo | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias |
Nausea Gabapentin vs placebo | RR 0.5 [0.05, 5.04] | 1 study · 18 participants | Very low Downgraded: risk of bias |
Constipation Gabapentin vs placebo | RR 0.14 [0.01, 2.54] | 1 study · 18 participants | Very low Downgraded: risk of bias |
Carbamazepine compared with placebo for pain in Guillain‐Barré syndrome
Population: patients with pain in Guillain‐Barré syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with self reported pain relief of 50% or greater (not measured) Carbamazepine vs placebo | no estimate extracted | NR | No studies |
Pain score (numerical rating scale of 0 to 10: 0 = no pain, 10 = worst pain) Carbamazepine vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias |
Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) Carbamazepine vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias |
Rescue analgesic consumption Carbamazepine vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias |
Methylprednisolone compared with placebo for pain in Guillain‐Barré syndrome
Population: patients with Guillain‐Barré syndrome, with varying severities of pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with self reported pain relief of 50% or greater (not measured) Methylprednisolone vs placebo | no estimate extracted | NR | No studies |
Number of participants with pain after 4 weeks Methylprednisolone vs placebo | RR 0.89 [0.68, 1.16] | 1 study · 223 participants | Low Downgraded: risk of bias |
Number of participants with decreased pain after 4 weeks Methylprednisolone vs placebo | RR 0.95 [0.63, 1.42] | 1 study · 223 participants | Low Downgraded: risk of bias |
Number of participants with increased pain after 4 weeks Methylprednisolone vs placebo | RR 0.85 [0.52, 1.41] | 1 study · 223 participants | Low Downgraded: risk of bias |
Gabapentin compared with carbamazepine for pain in Guillain‐Barré syndrome
Population: intensive care unit in India
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with self reported pain relief of 50% or greater (not measured) Gabapentin vs carbamazepine | no estimate extracted | NR | No studies |
Pain score (numerical rating scale of 0 to 10: 0 = no pain, 10 = worst pain) Gabapentin vs carbamazepine | no estimate extracted | 24 participants | Very low Downgraded: risk of bias |
Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) Gabapentin vs carbamazepine | no estimate extracted | 24 participants | Very low Downgraded: risk of bias |
Rescue analgesic consumption Gabapentin vs carbamazepine | no estimate extracted | 24 participants | Very low Downgraded: risk of bias |
Gabapentin compared with placebo for pain in Guillain‐Barré syndrome
Population: patients with pain in Guillain‐Barré syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with self reported pain relief of 50% or greater (not measured) Gabapentin vs placebo | no estimate extracted | NR | No studies |
Pain score (numerical rating scale of 0 to 10: 0 = no pain, 10 = worst pain) Gabapentin vs placebo | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias |
Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) Gabapentin vs placebo | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias |
Rescue analgesic consumption Gabapentin vs placebo | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias |
Nausea Gabapentin vs placebo | RR 0.5 [0.05, 5.04] | 1 study · 18 participants | Very low Downgraded: risk of bias |
Constipation Gabapentin vs placebo | RR 0.14 [0.01, 2.54] | 1 study · 18 participants | Very low Downgraded: risk of bias |
Carbamazepine compared with placebo for pain in Guillain‐Barré syndrome
Population: patients with pain in Guillain‐Barré syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with self reported pain relief of 50% or greater (not measured) Carbamazepine vs placebo | no estimate extracted | NR | No studies |
Pain score (numerical rating scale of 0 to 10: 0 = no pain, 10 = worst pain) Carbamazepine vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias |
Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) Carbamazepine vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias |
Rescue analgesic consumption Carbamazepine vs placebo | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias |
Methylprednisolone compared with placebo for pain in Guillain‐Barré syndrome
Population: patients with Guillain‐Barré syndrome, with varying severities of pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with self reported pain relief of 50% or greater (not measured) Methylprednisolone vs placebo | no estimate extracted | NR | No studies |
Number of participants with pain after 4 weeks Methylprednisolone vs placebo | RR 0.89 [0.68, 1.16] | 1 study · 223 participants | Low Downgraded: risk of bias |
Number of participants with decreased pain after 4 weeks Methylprednisolone vs placebo | RR 0.95 [0.63, 1.42] | 1 study · 223 participants | Low Downgraded: risk of bias |
Number of participants with increased pain after 4 weeks Methylprednisolone vs placebo | RR 0.85 [0.52, 1.41] | 1 study · 223 participants | Low Downgraded: risk of bias |
Gabapentin compared with carbamazepine for pain in Guillain‐Barré syndrome
Population: intensive care unit in India
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of patients with self reported pain relief of 50% or greater (not measured) Gabapentin vs carbamazepine | no estimate extracted | NR | No studies |
Pain score (numerical rating scale of 0 to 10: 0 = no pain, 10 = worst pain) Gabapentin vs carbamazepine | no estimate extracted | 24 participants | Very low Downgraded: risk of bias |
Sedation score (numerical rating scale of 1 to 6: 0 = anxious, agitated, or restless, 6 = asleep, no response) Gabapentin vs carbamazepine | no estimate extracted | 24 participants | Very low Downgraded: risk of bias |
Rescue analgesic consumption Gabapentin vs carbamazepine | no estimate extracted | 24 participants | Very low Downgraded: risk of bias |