Cochrane · systematic review · CD009622
Gamma aminobutyric acid (GABA) receptor agonists for acute stroke
Liu, J, Zhang, J, Wang, LN · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 87.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyChlormethiazole compared with placebo for acute stroke
Population: people with acute stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or dependency Chlormethiazole vs placebo | RR 1.03 [0.96, 1.11] | 4 studies · 2909 participants | Moderate Downgraded: risk of bias |
Adverse events Chlormethiazole vs placebo | RR 4.56 [3.5, 5.95] | 2 studies · 2527 participants | Moderate Downgraded: risk of bias |
Functional independence Chlormethiazole vs placebo | RR 0.98 [0.92, 1.05] | 4 studies · 2909 participants | Moderate Downgraded: risk of bias |
Other stroke scales Chlormethiazole vs placebo | no estimate extracted | 2 studies · 1367 participants | Moderate Downgraded: risk of bias |
Diazepam compared with placebo for acute stroke
Population: people with acute stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or dependency Diazepam vs placebo | RR 0.94 [0.82, 1.07] | 1 study · 849 participants | Moderate Downgraded: imprecision |
Adverse events Diazepam vs placebo | RR 0.99 [0.75, 1.31] | 1 study · 865 participants | Moderate Downgraded: imprecision |
Functional independence Diazepam vs placebo | RR 1.07 [0.93, 1.22] | 1 study · 849 participants | Moderate Downgraded: imprecision |
Other stroke scales Diazepam vs placebo | no estimate extracted | NR | No studies |
Chlormethiazole compared with placebo for acute stroke
Population: people with acute stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or dependency Chlormethiazole vs placebo | RR 1.03 [0.96, 1.11] | 4 studies · 2909 participants | Moderate Downgraded: risk of bias |
Adverse events Chlormethiazole vs placebo | RR 4.56 [3.5, 5.95] | 2 studies · 2527 participants | Moderate Downgraded: risk of bias |
Functional independence Chlormethiazole vs placebo | RR 0.98 [0.92, 1.05] | 4 studies · 2909 participants | Moderate Downgraded: risk of bias |
Other stroke scales Chlormethiazole vs placebo | no estimate extracted | 2 studies · 1367 participants | Moderate Downgraded: risk of bias |
Diazepam compared with placebo for acute stroke
Population: people with acute stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or dependency Diazepam vs placebo | RR 0.94 [0.82, 1.07] | 1 study · 849 participants | Moderate Downgraded: imprecision |
Adverse events Diazepam vs placebo | RR 0.99 [0.75, 1.31] | 1 study · 865 participants | Moderate Downgraded: imprecision |
Functional independence Diazepam vs placebo | RR 1.07 [0.93, 1.22] | 1 study · 849 participants | Moderate Downgraded: imprecision |
Other stroke scales Diazepam vs placebo | no estimate extracted | NR | No studies |