Cochrane · systematic review · CD009577
Long‐acting FSH versus daily FSH for women undergoing assisted reproduction
Pouwer, AW, Farquhar, C, Kremer, JAM · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 33.3%Low 1 · 16.7%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyLong‐acting FSH (all doses) versus daily FSH for women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate ‐ Low dose (60 to 120 μg) Long‐acting FSH (all doses) vs daily FSH | RR 0.7 [0.52, 0.93] | 3 studies · 645 participants | Moderate Downgraded: imprecision |
Live birth rate ‐ Medium dose (150 to 180 μg) Long‐acting FSH (all doses) vs daily FSH | RR 1.03 [0.9, 1.18] | 4 studies · 1685 participants | Moderate Downgraded: risk of bias |
Live birth rate ‐ High dose (240 μg) Long‐acting FSH (all doses) vs daily FSH | RR 0.43 [0.12, 1.52] | 1 study · 33 participants | Very low Downgraded: risk of bias, imprecision |
OHSS ‐ Low dose (60 to 120 μg) Long‐acting FSH (all doses) vs daily FSH | RR 1.22 [0.56, 2.66] | 3 studies · 645 participants | Moderate Downgraded: risk of bias, imprecision |
OHSS ‐ Medium dose (150 to 180 μg) Long‐acting FSH (all doses) vs daily FSH | RR 0.96 [0.68, 1.35] | 5 studies · 3075 participants | Low Downgraded: risk of bias, imprecision |
OHSS ‐ High dose (240 μg) Long‐acting FSH (all doses) vs daily FSH | RR 1.73 [0.09, 32.75] | 1 study · 33 participants | Very low Downgraded: risk of bias, imprecision |
Long‐acting FSH (all doses) versus daily FSH for women undergoing assisted reproduction
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate ‐ Low dose (60‐120 μg) Long‐acting FSH (all doses) vs daily FSH | OR 0.61 [0.41, 0.91] | 3 studies · 645 participants | Low Downgraded: publication bias |
Live birth rate ‐ Medium dose (150‐180 μg) Long‐acting FSH (all doses) vs daily FSH | OR 1.03 [0.84, 1.27] | 3 studies · 1657 participants | Low Downgraded: publication bias |
Live birth rate ‐ High dose (240 μg) Long‐acting FSH (all doses) vs daily FSH | OR 0.32 [0.05, 1.9] | 1 study · 33 participants | Low Downgraded: publication bias |
Ovarian hyperstimulation syndrome ‐ Low dose (60‐120 μg) Long‐acting FSH (all doses) vs daily FSH | OR 1.23 [0.54, 2.82] | 3 studies · 645 participants | Low Downgraded: publication bias |
Ovarian hyperstimulation syndrome ‐ Medium dose (150‐180 μg) Long‐acting FSH (all doses) vs daily FSH | OR 1.07 [0.72, 1.58] | 3 studies · 1657 participants | Low Downgraded: publication bias |
Ovarian hyperstimulation syndrome ‐ High dose (240 μg) Long‐acting FSH (all doses) vs daily FSH | OR 1.81 [0.08, 41.62] | 1 study · 33 participants | Low Downgraded: publication bias |