Cochrane · systematic review · CD009530
Bronchoscopy‐guided antimicrobial therapy for cystic fibrosis
Jain, K, Wainwright, CE, Smyth, AR · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyBAL‐directed therapy versus standard therapy for cystic fibrosis
Population: infants and children with pulmonary exacerbations in cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1: z score BAL‐directed therapy vs standard therapy | no estimate extracted | 2 studies · 186 participants | Low Downgraded: imprecision, indirectness |
FVC: absolute z score BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Low Downgraded: imprecision, indirectness |
HRCT score BAL‐directed therapy vs standard therapy | no estimate extracted | 2 studies · 181 participants | Moderate Downgraded: imprecision, indirectness |
Nutritional parameters: z score for weight BAL‐directed therapy vs standard therapy | no estimate extracted | 2 studies · 186 participants | Low Downgraded: imprecision, indirectness |
Number of positive P aeruginosa isolates BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Low Downgraded: imprecision, indirectness |
Hospitalisations: number per participant per year BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Low Downgraded: imprecision, indirectness |
Cost of hospital care per participant (AUD) BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate Downgraded: imprecision, indirectness |
BAL‐directed therapy versus standard therapy for cystic fibrosis
Population: people with pulmonary exacerbations in cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Z score FEV1 BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Low Downgraded: indirectness |
Z score FVC BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Low Downgraded: indirectness |
HRCT score (Brody‐II) BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 152 participants | Moderate Downgraded: indirectness |
Z score for weight BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Low Downgraded: indirectness |
Z score BMI BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Low Downgraded: indirectness |
Number of hospitalizations per participant per year BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Low Downgraded: indirectness |
Overall cost of care per participant (AUD) BAL‐directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate Downgraded: indirectness |
BAL directed therapy versus standard therapy for cystic fibrosis
Population: people with pulmonary exacerbations in cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Z score FEV1 BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
Z score FVC BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
HRCT score (Brody‐II) BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 152 participants | High |
Z score for weight BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
Z score BMI BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
Number of hospitalizations per participant per year BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
Overall cost of care per participant (AUD) BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | High |
BAL directed therapy versus standard therapy for cystic fibrosis
Population: patients with pulmonary exacerbations in cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
z score FEV1 spirometry BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
z score FVC spirometry BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
HRCT score (Brody‐II) HRCT scan BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 152 participants | High |
z score for weight weight BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
Number of hospitalizations per patient per year BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
z score BMI weight in kg/height in meters squared BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |
Days as hospital inpatient per patient per year BAL directed therapy vs standard therapy | no estimate extracted | 1 study · 157 participants | Moderate |