Cochrane · systematic review · CD009318
Lacosamide for neuropathic pain and fibromyalgia in adults
Hearn, L, Derry, S, Moore, RA · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
NeuromuscularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 25%Ungraded 1 · 12.5%Very low 0 · 0%Low 2 · 25%Moderate 3 · 37.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: painful diabetic neuropathy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
"Substantial" benefit At least 50% reduction in pain or equivalent | no estimate extracted | 412 participants | Low |
"Moderate" benefit At least 30% reduction in pain | no estimate extracted | 715 participants | Low |
Proportion below 30/100 mm on VAS | no estimate extracted | NR | No studies |
Patient global impression much or very much improved | no estimate extracted | 715 participants | Moderate |
Quality of life measure | no estimate extracted | NR | No studies |
Adverse event withdrawals | no estimate extracted | 874 participants | Moderate |
Serious adverse events | no estimate extracted | 1304 participants | Moderate |
Death | no estimate extracted | 400 participants | Ungraded |