Cochrane · systematic review · CD008959
Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age
Suchdev, PS, Jefferds, MED, Ota, E, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
7
No studies
5
Included studies
NR
No studies 5 · 41.7%Ungraded 0 · 0%Very low 1 · 8.3%Low 2 · 16.7%Moderate 3 · 25%High 1 · 8.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHome (point‐of‐use) fortification of foods with multiple micronutrient powders versus no intervention or placebo in children under two years of age
Population: children 6 to 23 months of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anaemia (haemoglobin values lower than 110 g/L) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs no intervention or placebo | RR 0.82 [0.76, 0.9] | 16 studies · 9927 participants | Moderate Downgraded: inconsistency |
Iron deficiency (as defined by trialists) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs no intervention or placebo | RR 0.47 [0.39, 0.56] | 7 studies · 1634 participants | High |
Haemoglobin concentration (g/L) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs no intervention or placebo | no estimate extracted | 20 studies · 10509 participants | Low Downgraded: risk of bias, inconsistency |
Iron status (ferritin concentrations in μg/L) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs no intervention or placebo | no estimate extracted | 7 studies · 2612 participants | Moderate Downgraded: inconsistency |
Weight‐for‐age (z scores) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs no intervention or placebo | no estimate extracted | 10 studies · 9287 participants | Moderate Downgraded: risk of bias |
All‐cause mortality Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs no intervention or placebo | no estimate extracted | NR | No studies |
Home (point‐of‐use) fortification of foods with multiple micronutrient powders versus an iron‐only supplement in children under two years of age
Population: children 6 to 23 months of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anaemia (haemoglobin values lower than 110 g/L) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs an iron‐only supplement | RR 0.89 [0.58, 1.39] | 1 study · 145 participants | Low Downgraded: imprecision |
Iron deficiency (as defined by trialists) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs an iron‐only supplement | no estimate extracted | NR | No studies |
Haemoglobin concentration (g/L) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs an iron‐only supplement | no estimate extracted | 2 studies · 278 participants | Very low Downgraded: imprecision, inconsistency |
Iron status (as defined by trialists) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs an iron‐only supplement | no estimate extracted | NR | No studies |
Weight‐for‐age (z scores) Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs an iron‐only supplement | no estimate extracted | NR | No studies |
All‐cause mortality Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs an iron‐only supplement | no estimate extracted | NR | No studies |
Provision of multiple micronutrient powders versus placebo or no intervention in children less than 2 years
Population: children 6 to 23 months
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anaemia Provision of multiple micronutrient powders vs placebo or no intervention | RR 0.69 [0.6, 0.78] | 6 studies · 1447 participants | Moderate |
Iron deficiency Provision of multiple micronutrient powders vs placebo or no intervention | RR 0.49 [0.35, 0.67] | 4 studies · 586 participants | High |
Haemoglobin (g/L) Provision of multiple micronutrient powders vs placebo or no intervention | MD 5.87 [3.25, 8.49] | 6 studies · 1447 participants | Moderate |
Iron status (ferritin concentrations in ng/mL) Provision of multiple micronutrient powders vs placebo or no intervention | MD 20.38 [6.27, 34.49] | 2 studies · 264 participants | Low |
Weight‐for‐age Z‐score Provision of multiple micronutrient powders vs placebo or no intervention | MD 0 | 2 studies · 304 participants | Moderate |
All‐cause mortality Provision of multiple micronutrient powders vs placebo or no intervention | no estimate extracted | 0 studies · 0 participants | Ungraded |
Provision of multiple micronutrient powders versus iron supplements in children less than 2 years
Population: children 6 to 23 months
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anaemia Provision of multiple micronutrient powders vs iron supplements | RR 0.89 [0.58, 1.39] | 1 study · 145 participants | Low |
Iron deficiency Provision of multiple micronutrient powders vs iron supplements | no estimate extracted | 0 studies · 0 participants | Ungraded |
Haemoglobin (g/L) Provision of multiple micronutrient powders vs iron supplements | no estimate extracted | 2 studies · 278 participants | Low |
Iron status (ferritin concentrations in ng/mL) Provision of multiple micronutrient powders vs iron supplements | no estimate extracted | 0 studies · 0 participants | Ungraded |
Weight‐for‐age Z‐score Provision of multiple micronutrient powders vs iron supplements | no estimate extracted | 0 studies · 0 participants | Ungraded |
All‐cause mortality Provision of multiple micronutrient powders vs iron supplements | no estimate extracted | 0 studies · 0 participants | Ungraded |