Cochrane · systematic review · CD008932
Nipple‐ and areola‐sparing mastectomy for the treatment of breast cancer
Mota, BS, Riera, R, Ricci, MD, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Nipple‐sparing mastectomy for breast cancer treatment
Population: women with breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival | HR 0.72 [0.46, 1.13] | 2 studies · 1202 participants | Very low Downgraded: risk of bias |
Local recurrence | HR 0.28 [0.12, 0.68] | 2 studies · 1311 participants | Very low Downgraded: risk of bias, imprecision |
Overall complications | RR 0.1 [0.01, 0.82] | 2 studies · 1067 participants | Low Downgraded: inconsistency |
Skin necrosis | RR 4.22 [0.59, 30.03] | 4 studies · 1948 participants | Very low Downgraded: inconsistency |
Infection | RR 0.95 [0.44, 2.09] | 2 studies · 496 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Nipple‐sparing mastectomy for breast cancer treatment
Population: women with breast cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival | HR 0.7 [0.28, 1.72] | 2 studies · 781 participants | Very low Downgraded: risk of bias, imprecision |