Cochrane · systematic review · CD008685
Optimal loading dose of warfarin for the initiation of oral anticoagulation
Mahtani, KR, Heneghan, CJ, Nunan, D, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
5 mg versus 10 mg for the initiation of oral anticoagulation
Population: patients with the initiation of oral anticoagulation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All studies 5 mg vs 10 mg | RR 1.17 [0.77, 1.77] | 4 studies · 352 participants | Very low Downgraded: risk of bias, publication bias |
Single INR measure 5 mg vs 10 mg | RR 1.49 [1.01, 2.21] | 2 studies · 250 participants | Very low Downgraded: risk of bias, publication bias |
Consecutive INR measures 5 mg vs 10 mg | RR 0.86 [0.62, 1.19] | 2 studies · 102 participants | Very low Downgraded: risk of bias, publication bias |