Cochrane · systematic review · CD008502
Baclofen for alcohol withdrawal
Liu, J, Wang, LN · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
27
current version
GRADE rated
10
No studies
17
Included studies
NR
No studies 17 · 63%Ungraded 0 · 0%Very low 10 · 37%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyBaclofen compared with placebo for alcohol withdrawal
Population: people with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AW seizures Baclofen vs placebo | no estimate extracted | NR | No studies |
AW delirium Baclofen vs placebo | no estimate extracted | NR | No studies |
AW symptoms (CIWA‐Ar score) Baclofen vs placebo | no estimate extracted | 1 study · 31 participants | Very low Downgraded: risk of bias, imprecision |
Global improvement Baclofen vs placebo | no estimate extracted | NR | No studies |
Craving Baclofen vs placebo | no estimate extracted | NR | No studies |
AEs Baclofen vs placebo | no estimate extracted | NR | No studies |
Severe AEs Baclofen vs placebo | no estimate extracted | NR | No studies |
Dropouts Baclofen vs placebo | no estimate extracted | NR | No studies |
Dropouts due to AEs Baclofen vs placebo | no estimate extracted | NR | No studies |
Baclofen compared with diazepam for alcohol withdrawal
Population: people with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AW seizures Baclofen vs diazepam | no estimate extracted | NR | No studies |
AW delirium Baclofen vs diazepam | no estimate extracted | NR | No studies |
AW symptoms (CIWA‐Ar score) Baclofen vs diazepam | no estimate extracted | 2 studies · 85 participants | Very low Downgraded: risk of bias, imprecision |
Global improvement Baclofen vs diazepam | no estimate extracted | NR | No studies |
Craving Baclofen vs diazepam | no estimate extracted | NR | No studies |
AEs Baclofen vs diazepam | RD 0 | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision |
Severe AEs Baclofen vs diazepam | no estimate extracted | NR | No studies |
Dropouts Baclofen vs diazepam | RD 0 | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision |
Dropouts due to AEs Baclofen vs diazepam | RD 0 | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision |
Baclofen compared with chlordiazepoxide for alcohol withdrawal
Population: people with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AW seizures Baclofen vs chlordiazepoxide | no estimate extracted | NR | No studies |
AW delirium Baclofen vs chlordiazepoxide | no estimate extracted | NR | No studies |
AW symptoms (CIWA‐Ar score) Baclofen vs chlordiazepoxide | MD 1 [0.7, 1.3] | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Global improvement Baclofen vs chlordiazepoxide | MD 0.1 | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Craving Baclofen vs chlordiazepoxide | no estimate extracted | NR | No studies |
AEs Baclofen vs chlordiazepoxide | RR 2.5 [0.88, 7.1] | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Severe AEs Baclofen vs chlordiazepoxide | no estimate extracted | NR | No studies |
Dropouts Baclofen vs chlordiazepoxide | RD 0 | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Dropouts due to AEs Baclofen vs chlordiazepoxide | RD 0 | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Baclofen compared with placebo for alcohol withdrawal
Population: people with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AW seizures Baclofen vs placebo | no estimate extracted | NR | No studies |
AW delirium Baclofen vs placebo | no estimate extracted | NR | No studies |
AW symptoms (CIWA‐Ar score) Baclofen vs placebo | no estimate extracted | 1 study · 31 participants | Very low Downgraded: risk of bias |
Global improvement Baclofen vs placebo | no estimate extracted | NR | No studies |
Craving Baclofen vs placebo | no estimate extracted | NR | No studies |
AEs Baclofen vs placebo | no estimate extracted | NR | No studies |
Severe AEs Baclofen vs placebo | no estimate extracted | NR | No studies |
Dropouts Baclofen vs placebo | no estimate extracted | NR | No studies |
Dropouts due to AEs Baclofen vs placebo | no estimate extracted | NR | No studies |
Baclofen compared with diazepam for alcohol withdrawal
Population: people with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AW seizures Baclofen vs diazepam | no estimate extracted | NR | No studies |
AW delirium Baclofen vs diazepam | no estimate extracted | NR | No studies |
AW symptoms (CIWA‐Ar score) Baclofen vs diazepam | no estimate extracted | 1 study · 37 participants | Very low Downgraded: risk of bias |
Global improvement Baclofen vs diazepam | no estimate extracted | NR | No studies |
Craving Baclofen vs diazepam | no estimate extracted | NR | No studies |
AEs Baclofen vs diazepam | RD 0 | 1 study · 37 participants | Very low Downgraded: risk of bias |
Severe AEs Baclofen vs diazepam | no estimate extracted | NR | No studies |
Dropouts Baclofen vs diazepam | RD 0 | 1 study · 37 participants | Very low Downgraded: risk of bias |
Dropouts due to AEs Baclofen vs diazepam | RD 0 | 1 study · 37 participants | Very low Downgraded: risk of bias |
Baclofen compared with chlordiazepoxide for alcohol withdrawal
Population: people with alcohol withdrawal
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
AW seizures Baclofen vs chlordiazepoxide | no estimate extracted | NR | No studies |
AW delirium Baclofen vs chlordiazepoxide | no estimate extracted | NR | No studies |
AW symptoms (CIWA‐Ar score) Baclofen vs chlordiazepoxide | MD 1 [0.7, 1.3] | 1 study · 60 participants | Very low Downgraded: risk of bias |
Global improvement Baclofen vs chlordiazepoxide | MD 0.1 | 1 study · 60 participants | Very low Downgraded: risk of bias |
Craving Baclofen vs chlordiazepoxide | no estimate extracted | NR | No studies |
AEs Baclofen vs chlordiazepoxide | RR 2.5 [0.88, 7.1] | 1 study · 60 participants | Very low Downgraded: risk of bias |
Severe AEs Baclofen vs chlordiazepoxide | no estimate extracted | NR | No studies |
Dropouts Baclofen vs chlordiazepoxide | RD 0 | 1 study · 60 participants | Very low Downgraded: risk of bias |
Dropouts due to AEs Baclofen vs chlordiazepoxide | RD 0 | 1 study · 60 participants | Very low Downgraded: risk of bias |