Cochrane · systematic review · CD008481
Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections
Shiu, JR, Wang, E, Tejani, AM, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Continuous versus Intermittent Antibiotic Infusions for Treatment of Severe Bacterial Infections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Continuous vs Intermittent Antibiotic Infusions | RR 0.89 [0.67, 1.2] | 19 studies · 1241 participants | Moderate |
Infection recurrence Continuous vs Intermittent Antibiotic Infusions | RR 1.22 [0.35, 4.19] | 8 studies · 398 participants | Low |
Clinical cure Continuous vs Intermittent Antibiotic Infusions | RR 1.04 [0.95, 1.13] | 15 studies · 975 participants | Low |
Super‐infection Continuous vs Intermittent Antibiotic Infusions | RR 1.08 [0.6, 1.94] | 12 studies · 813 participants | Low |
Serious adverse events Continuous vs Intermittent Antibiotic Infusions | RR 1.36 [0.8, 2.3] | 10 studies · 871 participants | Low |
Withdrawal due to adverse events Continuous vs Intermittent Antibiotic Infusions | RR 2.03 [0.52, 7.95] | 10 studies · 871 participants | Low |
Adverse events Continuous vs Intermittent Antibiotic Infusions | RR 1.02 [0.94, 1.12] | 5 studies · 575 participants | Very low |